Fluorescence imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor. The method includes reducing fixed pattern noise in an exposure frame by subtracting a reference frame from the exposure frame. The method is such that at least a portion of the plurality of pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

A processing device may execute instructions from a computer readable medium to perform operations comprising: making a comparison between first image data of at least a portion of a dental arch and second image data of at least the portion of the dental arch; determining a plurality of differences between a first representation of at least the portion of the dental arch in the first image data and a second representation of at least the portion of the dental arch in the second image data; determining that a first difference of the plurality of differences is attributable to tooth movement; determining that a second difference of the plurality of differences is attributable to tooth wear to one or more teeth on at least a portion of the dental arch; and generating a third representation of at least the portion of the dental arch that is a modified version of the second representation, wherein a visual indication of the tooth wear is provided in the third representation.

In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

[Object] To propose an information processing device, an image acquisition system, an information processing method, an image information acquisition method, and a program which enable a position of a surface of a measurement subject to be more simply specified.

[Solution] An information processing device according to the present invention includes: a representative luminance value specifying unit configured to, when luminance values constituting a plurality of fluorescence images of a measurement subject captured while a position of the measurement subject in a thickness direction is changed are sequentially rearranged from a highest luminance value on the basis of the fluorescence images for each of the fluorescence images corresponding to respective thickness positions, extract a luminance value ranked at a predetermined position from the highest luminance value and set the extracted luminance value as a representative luminance value of the fluorescence image at the thickness position to be noted; and a surface position specifying unit configured to use the representative luminance value for each of the fluorescence images and set the thickness position corresponding to the fluorescence image that gives the maximum representative luminance value as a position corresponding to a surface of the measurement subject.

A novel dual-path-endoscope where a multi-function light source produces a first-light and a second-light toward an object. The first-light exhibits first-light-characteristics. The second-light exhibits second-light-characteristics different from the first-light-characteristics. The endoscope includes two light-paths, the disparity there between is larger than zero. Each light-path includes a respective pupil and a respective light-separator coupled with the pupil, transmitting there through one of the first-light and the second-light, associating the first-light and the second-light with a respective light-path. The dual-channel-imager includes two imaging sensors, each associated with a respective light-path and optically coupled with a respective light-separator. Each imaging-sensor exhibits sensitivity to the characteristics of the respective one of the first-light and the second-light. A first imaging-sensor acquires a first-image of the first-light reflected of the object and a second imaging-sensor acquires a second-image of the second-light reflected of the object. The processor processes the acquired images.

An endoscope system includes an image acquisition section, an attention area setting section, and a dimming control section. The image acquisition section acquires a captured image that includes an object image. The attention area setting section sets an attention area within the captured image based on information from the endoscope system. The dimming control section performs a dimming control process that controls the intensity of illumination light based on the attention area set by the attention area setting section.

An endoscope apparatus enables observation using reflected light of white light and observation using fluorescence, and includes: an insertion portion configured to be insertable into a subject; an objective optical system; a transmitting optical system; a camera unit; an optical splitter configured to split light exiting through the transmitting optical system; an optical filter disposed in the transmitting optical system or the camera unit, the optical filter being configured to transmit the reflected light of the white light and the fluorescence and block the reflected light of the excitation light; a first image pickup device for picking up an image of the reflected light of the white light exiting through the optical filter and the optical splitter; and a second image pickup device for picking up an image of the fluorescence exiting through the optical filter and the optical splitter.

The present invention relates to a device for observing a sentinel lymph node (SLN) in a human body. More particularly, the present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and/or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.

An endoscope includes a four color separation prism having a first color separation prism, a second color separation prism, a third color separation prism, and a fourth color separation prism which respectively separate light incident from an affected area into a blue, red and green color components, and an IR component, first, second, third and fourth color image sensors, and a signal output. The first color separation prism, the second color separation prism, the third color separation prism, and the fourth color separation prism are sequentially disposed from an object side when receiving the light incident from the affected area. The first color image sensor is disposed opposite to the second color image sensor and the third color image sensor across an incident ray which is incident vertically to an object side incident surface of the first color separation prism.

An optical endoluminal far-field microscopic imaging catheter comprises a light generating system, a first light delivery conduit for propagating light generated by the light generating system and a light distributor configured to redirect light propagated by the delivery conduit into a direction of an object to be imaged. A discriminator is configured for capturing light reflected from the object incident on a window of the discriminator from a particular direction and transmitting only the light captured from the particular direction to a second light delivery conduit. A drive mechanism is configured to sweep the window through a plurality of directions in a predictable pattern for matching each light capture event in the window with a direction of the window during the event. An analyzer matches the direction of the window with an associated light capture event and generate a visible image based on a mosaic of the captured light.