To provide a novel pesticide, especially a fungicide and a nematocide. An oxime-substituted amide compound represented by the formula (I) or its salt, and a pesticide containing it: ##STR00001##
wherein G.sup.1 is a structure represented by G.sup.1-1 or the like, G.sup.2 is a structure represented by G.sup.2-2 or the like: ##STR00002##
W is an oxygen atom or the like, X.sup.1 is a halogen atom, methyl, trifluoromethyl or the like, each of X.sup.2, X.sup.3, X.sup.4 and X.sup.5 is independently a hydrogen atom, a halogen atom or the like, each of Y.sup.1 and Y.sup.3 is independently a halogen atom, cyano, methyl, trifluoromethyl, C.sub.2-C.sub.6 alkynyl or the like, each of Y.sup.2 and Y.sup.4 is independently a hydrogen atom, a halogen atom or the like, R.sup.1 is C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.4 haloalkyl, (C.sub.1-C.sub.4)alkyl substituted with R.sup.18, C.sub.3-C.sub.6 cycloalkyl, C.sub.3-C.sub.6 alkenyl or the like, each of R.sup.2 and R.sup.3 is independently a hydrogen atom, methyl or the like, R.sup.4 is a hydrogen atom or the like, R.sup.18 is C.sub.3-C.sub.6 cycloalkyl, phenyl, phenyl substituted with (Z).sub.m or the like, Z is a halogen atom or the like, and m is an integer of 1, 2 or 3.

To provide a novel pesticide, especially a fungicide and a nematocide. An oxime-substituted amide compound represented by the formula (I) or its salt, and a pesticide containing it: ##STR00001##
wherein G.sup.1 is a structure represented by G.sup.1-1 or the like, G.sup.2 is a structure represented by G.sup.2-2 or the like: ##STR00002##
W is an oxygen atom or the like, X.sup.1 is a halogen atom, methyl, trifluoromethyl or the like, each of X.sup.2, X.sup.3, X.sup.4 and X.sup.5 is independently a hydrogen atom, a halogen atom or the like, each of Y.sup.1 and Y.sup.3 is independently a halogen atom, cyano, methyl, trifluoromethyl, C.sub.2-C.sub.6 alkynyl or the like, each of Y.sup.2 and Y.sup.4 is independently a hydrogen atom, a halogen atom or the like, R.sup.1 is C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.4 haloalkyl, (C.sub.1-C.sub.4)alkyl substituted with R.sup.18, C.sub.3-C.sub.6 cycloalkyl, C.sub.3-C.sub.6 alkenyl or the like, each of R.sup.2 and R.sup.3 is independently a hydrogen atom, methyl or the like, R.sup.4 is a hydrogen atom or the like, R.sup.18 is C.sub.3-C.sub.6 cycloalkyl, phenyl, phenyl substituted with (Z).sub.m or the like, Z is a halogen atom or the like, and m is an integer of 1, 2 or 3.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

##STR00001##

and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

##STR00001##

and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): ##STR00001##
and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): ##STR00001##
and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.

##STR00001##

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.

##STR00001##

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes. ##STR00001##

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes. ##STR00001##