In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for automatically transforming a digital image into a simulated pathology image are provided. In some embodiments, the method comprises: receiving a content image from an endomicroscopy device; receiving, from a hidden layer of a convolutional neural network (CNN) trained to recognize a multitude of classes of common objects, features indicative of content of the content image; receiving, providing a style reference image to the CNN; receiving, from another hidden layer of the CNN, features indicative of a style of the style reference image; receiving, from the hidden layers of the CNN, features indicative of content and style of a target image; generating a loss value based on the features of the content image, the style reference image, and the target image; minimizing the loss value; and displaying the target image with the minimized loss.

A sheath cap includes a housing collar and a cylinder which is coaxially fixed on the inner surface of one end of the housing collar. The cylinder is internally provided with instrument channel straight holes and a water spray channel straight hole which are parallel to the axial direction of the cylinder. The sheath cap is provided with an oblique hole, which is in communication with the water spray channel straight hole and is configured to spray water to the lateral front side of the sheath cap.

An embodiment of an illumination system for use with an endoscope includes a laser source comprising laser light emitters, an electromagnetic sensor embedded within the laser source to sense light energy, and a control circuit in electronic communication with the electromagnetic sensor and at least one emitter. The control circuit is configured to cause the laser source to pulse light between pixel readout periods. The electromagnetic sensor receives light from at least one emitter and measures an amount of electromagnetic energy generated by at least one emitter. The control circuit controls a duty cycle of the emitters based on a predetermined, known output and in response the amount of electromagnetic energy generated by at least one of the emitters and obtains a desired exposure response for images captured by the image sensor.

A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.

An endoscope light source system includes a light source module, an insertion module and a light guide path. The light source system further includes a light connector which is provided on the light guide path and optically connects an auxiliary light guide path to the light guide path, such that auxiliary light is guided to the light guide path from the auxiliary light guide path which guides the auxiliary light; and an irradiation module which emits at least one of light-source light which is guided by the light guide path and the auxiliary light which is guided by the light guide path, to an outside of an endoscope as illumination light, and radiates the illumination light to a to-be-illuminated part.

An optical scanning endoscope device includes: a laser element; an optical fiber that guides laser light from the laser element; a first detector that detects a guided light amount of the laser light in the optical fiber; a second detector that detects light from a subject and outputs a detection signal; a first calculator that calculates an optical coupling ratio between the laser element and the optical fiber on the basis of the guided light amount; a second calculator that calculates a degradation ratio of the laser element on the basis of the guided light amount; a first adjuster that adjusts the magnitude of the detection signal on the basis of the optical coupling ratio; and a second adjuster that adjusts the output light amount of the laser light from the laser element on the basis of the degradation ratio.

A medical observation system according to an embodiment of the present technology includes a light source, an optical member, a first light guide body, and an imaging element. The light source has a plurality of light-emitting elements, each of which emits light. The optical member is arranged to reflect the light emitted from the plurality of light-emitting elements and make the reflected light incident on a first region. The first light guide body is arranged in the first region, has an incident end and an emission end on a side opposite to the incident end, and guides the light incident from the incident end to the emission end. The imaging element irradiates an operating field with the guided light and captures an image of light reflected by a subject.

The present invention relates to a minimally invasive medical instrument (100) having a proximal end (100b) and a distal end (100a) and comprising a sensor arrangement (10) arranged at the distal end (100b) of the medical instrument (100). The sensor arrangement (10) comprises a sensor (20) configured to generate sensor data in the form of an electrical sensor signal, and a data conversion device (40) configured to convert the electrical sensor signal into an optical signal and comprising an electrical input (41) for receiving the electrical sensor signal and an optical output (42) for transmitting the optical signal. The sensor arrangement (10) further comprises an optical fiber (50) configured to transmit the optical signal from the distal end (100a) to the proximal end (100b), the optical fiber (50) coupled to the output of the data conversion device (40) for receiving the optical signal, the optical fiber (50) extending from the distal end (100a) to the proximal end (100b) of the instrument (100). The present invention further relates to a method of manufacturing such a minimally invasive medical instrument (100).

Tip confirmation systems and related methods are disclosed. A method of determining one or more properties of a catheter in a patient comprises advancing a catheter in vasculature of a patient, the catheter coupled to at least one radiation source and at least one detector, transmitting source electromagnetic radiation from the at least one radiation source out of the catheter proximate a distal tip thereof, measuring an intensity of backscattered electromagnetic radiation from the at least one radiation source with the at least one detector, and providing a signal indicative of a location of the distal tip within the vasculature based, at least in part, on the measured intensity of the backscattered electromagnetic radiation. Related systems and methods are also disclosed.

System and methods for optical tissue interrogation are provided. In some embodiments, a catheter for visualizing ablated tissue is provided, and can include a catheter body, and a distal tip positioned at a distal end of the catheter body. The distal tip can have one or more openings for exchange of light energy between the distal tip of the catheter and tissue.