Disclosed are HPTS series derivatives and a synthesis method thereof, belonging to the field of organic synthesis. The HPTS series derivatives are prepared by introducing alkylamine or alcohol into sulfonic acid groups of HPTS. The synthesis method comprises the following steps: subjecting HPTS and phosphorus oxychloride to heating and reflux reaction for 12 hours under catalysis of DMF to obtain a reaction product; introducing the reaction product into ice water, stirring, precipitating solid, and performing suction filtration to obtain HPTS-SO.sub.2Cl; dissolving the HPTS-SO.sub.2Cl in tetrahydrofuran to prepare solution A, and dissolving alkylamine or alcohol in tetrahydrofuran to prepare solution B; mixing the solution A with the solution B and then reacting for 24 hours at normal temperature, obtaining a product by rotary evaporation, and obtaining a pure compound after separation through columns. The derivatives have strong fat solubility, overcome the defect of a very strong water solubility.

The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol derivative which can be utilized in various ways as a drug linker, and is appropriate and effective for mass production and is advantageous in reproducible mass production of high-quality products.

The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol derivative which can be utilized in various ways as a drug linker, and is appropriate and effective for mass production and is advantageous in reproducible mass production of high-quality products.

An object is to provide a thermosensitive recording material and a laminate which are excellent in color development sensitivity and favorable in storage characteristics such as heat resistance, plasticizer resistance, moisture resistance, oil resistance, and grease resistance. A thermosensitive recording material in which a thermosensitive recording layer is provided on a support, wherein the thermosensitive recording layer contains a specific diphenylsulfone compound and an analog compound thereof at a specific ratio. A laminate in which a thermosensitive recording layer is provided on a support, wherein the thermosensitive recording layer contains a specific diphenylsulfone compound and an analog compound thereof at a specific ratio.

An object of the present invention is to provide a recording material or a recording sheet using, as a color-developing agent, a non-phenol-based compound good in color developing performance and the like. A compound represented by the following formula (I) is used as the color-developing agent:

##STR00001##

(wherein X represents CH.sub.2 or the like; R.sup.1 to R.sup.3 each independently represent a hydrogen atom, a halogen atom or the like; n1 and n3 each independently represent any integer of 1 to 5; two groups represented by R.sup.3 adjacent to each other on a benzene ring optionally bond to each other to form an optionally substituted 6-membered ring; and n2 represents any integer of 1 to 4).

The invention relates to a method for preparing a compound comprising two phenyl groups by reacting a bisfuranic compound with a dienophile; and to such compounds.

The invention relates to a method for preparing a compound comprising two phenyl groups by reacting a bisfuranic compound with a dienophile; and to such compounds.

Provided is a sulfonic acid ester compound represented by formula (1). ##STR00001##
(In the formula, R.sup.1 and R.sup.2 each independently represent a hydrogen atom, or a straight-chain or branched monovalent aliphatic hydrocarbon group. R.sup.3 represents a straight-chain or branched monovalent aliphatic hydrocarbon group. The sum of the carbon numbers of R.sup.1, R.sup.2 and R.sup.3 is 6 or greater. A.sup.1 represents O or S. A.sup.2 represents an aromatic group having a valence of (n+1). A.sup.3 represents a hydrocarbon group which has a valence of m, and is unsubstituted or has a substituent that contains one or more aromatic rings. m represents an integer satisfying 2m4. n represents an integer satisfying 1n4).

Provided is a sulfonic acid ester compound represented by formula (1). ##STR00001##
(In the formula, R.sup.1 and R.sup.2 each independently represent a hydrogen atom, or a straight-chain or branched monovalent aliphatic hydrocarbon group. R.sup.3 represents a straight-chain or branched monovalent aliphatic hydrocarbon group. The sum of the carbon numbers of R.sup.1, R.sup.2 and R.sup.3 is 6 or greater. A.sup.1 represents O or S. A.sup.2 represents an aromatic group having a valence of (n+1). A.sup.3 represents a hydrocarbon group which has a valence of m, and is unsubstituted or has a substituent that contains one or more aromatic rings. m represents an integer satisfying 2m4. n represents an integer satisfying 1n4).

The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis.