Speckle removal in a pulsed fluorescence imaging system is described. A system includes a coherent light source for emitting pulses of coherent light, a fiber optic bundle connected to the coherent light source, and a vibrating mechanism attached to the fiber optic bundle. The system includes and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system is such that at least a portion of the pulses of coherent light emitted by the coherent light source comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

A method of generating a color image using a monochromatic image sensor. The method includes sequentially illuminating a surface in a plurality of colors, one color at a time. The monochromatic image sensor captures a plurality of image frames of the surface based on the plurality of colors. The plurality of image frames are identified, and at least one feature in the target of the plurality of image frames is highlighted. Color intensities of the plurality of image frames are normalized. A color intensity map of the target for each of the plurality of image frames is generated. A correlation score is determined by comparing each color intensity map of the plurality of image frames. The color image is generated based on the correlation score.

A high-resolution microendoscope system includes a light source, a fiber optic bundle configured to transmit light from the light source to a sample, a disc configured to receive light returned from the sample, the disc having spaced apart segments, the spaced-apart segments being at least one of openings and transparent portions, a first camera configured to capture a first image based at least in part on light passing through the disc, and a second camera configured to capture a second image based at least in part on light reflected from the disc.

A high-resolution microendoscope system includes a light source, a fiber optic bundle configured to transmit light from the light source to a sample, a disc configured to receive light returned from the sample, the disc having spaced apart segments, the spaced-apart segments being at least one of openings and transparent portions, a first camera configured to capture a first image based at least in part on light passing through the disc, and a second camera configured to capture a second image based at least in part on light reflected from the disc.

An air gap retractor illumination system includes any suitable retractor such as a McCulloch with a channel in the blade to accommodate an air gap illuminator. The illuminator is preferably made from a suitable light conducting plastic material such as acrylic or polycarbonate or silicone. The illuminator has active portions in which light passes and inactive or dead zones in which light does not pass as a result of the configuration and orientation of the input, output and surfaces of the illuminator. The illuminator is formed to have an air gap surrounding any active portion of the illuminator extending from the light input to the light output portion. The dead zones may include elements to allow the illuminator to securely engage the retractor. The light output portion of the illuminator contains from two to eight output zones, each zone having specially designed output optical structures that control and direct light to escape the illuminator to shine onto a predetermined area of interest or to form one or more predetermined shapes or footprints.

An air gap retractor illumination system includes any suitable retractor such as a McCulloch with a channel in the blade to accommodate an air gap illuminator. The illuminator is preferably made from a suitable light conducting plastic material such as acrylic or polycarbonate or silicone. The illuminator has active portions in which light passes and inactive or dead zones in which light does not pass as a result of the configuration and orientation of the input, output and surfaces of the illuminator. The illuminator is formed to have an air gap surrounding any active portion of the illuminator extending from the light input to the light output portion. The dead zones may include elements to allow the illuminator to securely engage the retractor. The light output portion of the illuminator contains from two to eight output zones, each zone having specially designed output optical structures that control and direct light to escape the illuminator to shine onto a predetermined area of interest or to form one or more predetermined shapes or footprints.

Endoscopes and methods of their use, where the endoscopes provide a low profile or cross-section which facilitates introduction through small body passages, such as patient's cervix, and into body cavities, such a patient's uterus.

Endoscopes and methods of their use, where the endoscopes provide a low profile or cross-section which facilitates introduction through small body passages, such as patient's cervix, and into body cavities, such a patient's uterus.

A method and device for the remote eradication of pathogens comprising a light source for emitting UV light in the pathogen killing wave length range, and a tangible transmission medium, which is at least initially resistant to degradation by the UV light. An optical interface between the UV light source and the tangible transmission medium is provided whereby the emitted UV light is collected from the light source and transmitted through the tangible transmission medium, whereby UV light emitted from the tangible transmission medium and directed against a pathogen in proximity thereto is at a power level sufficient to substantially effectively kill the pathogen within a reasonable period of time. The device is used for sanitization of biopsy channels of endoscopes and for treating of pathogens within humans and animals.

A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.