Substituted aromatic sulfonamides of formula (I)

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pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

A compound represented by formula (I) or formula (II) has a pest control effect. (In the formulae, Q.sup.1 represents a pyrazine ring or the like; G.sup.1 represents a nitrogen atom or a carbon atom; X.sup.1 represents an alkyl group or the like; m represents the number of X.sup.1 moieties; A represents an oxygen atom or the like; Y represents a single bond or the like; Q.sup.2 represents a benzene ring or the like; X.sup.2 represents an alkyl group, an aryl group or the like; X.sup.3 represents a halogeno group or the like; n represents the number of X.sup.3 moieties; Z.sup.q- represents a counter ion; and q represents 1 or 2.)

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A compound of formula (I) is:

##STR00001##

wherein: X.sup.2 represents a —CO—NR.sub.k— group, a —NR′.sub.k—CO— group, a —O— group, a —CO— group, a —SO.sub.2-group, a —CS—NH— group, a —CH.sub.2—NH—, a

##STR00002##

group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y.sup.2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a piperidinyl group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, a 5-membered heteroaromatic ring or a —CR.sup.1R.sup.2R.sup.3 group, or any of its pharmaceutically acceptable salt.

A compound of formula (I) is:

##STR00001##

wherein: X.sup.2 represents a —CO—NR.sub.k— group, a —NR′.sub.k—CO— group, a —O— group, a —CO— group, a —SO.sub.2-group, a —CS—NH— group, a —CH.sub.2—NH—, a

##STR00002##

group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y.sup.2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a piperidinyl group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, a 5-membered heteroaromatic ring or a —CR.sup.1R.sup.2R.sup.3 group, or any of its pharmaceutically acceptable salt.

The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.

The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.

The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD.sup.+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD.sup.+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.