Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein.

The present disclosure relates to a process for manufacturing at least one sartan active compound of formula (I)

##STR00001##

wherein R is selected from a group of formulas (1), (2), (3), (4) and (5), comprising the tetrazolylation of one compound of formula (II)

##STR00002##

wherein R is as previously defined, in a reactional medium with at least one azide derivative, wherein benzylic azide impurities formed during said tetrazolylation are converted into aldehyde derivatives.

The present disclosure relates to a process for manufacturing at least one sartan active compound of formula (I)

##STR00001##

wherein R is selected from a group of formulas (1), (2), (3), (4) and (5), comprising the tetrazolylation of one compound of formula (II)

##STR00002##

wherein R is as previously defined, in a reactional medium with at least one azide derivative, wherein benzylic azide impurities formed during said tetrazolylation are converted into aldehyde derivatives.

Isophthalamides of the general formula (I) are described as herbicides.

##STR00001##

In this formula (I), X, Y and Z represent radicals such as hydrogen, alkyl and halogen. Q represents a heterocyclic ring such as tetrazolyl.

Isophthalamides of the general formula (I) are described as herbicides.

##STR00001##

In this formula (I), X, Y and Z represent radicals such as hydrogen, alkyl and halogen. Q represents a heterocyclic ring such as tetrazolyl.

A compound represented by a formula (I) or a salt thereof; and a herbicide containing at least one selected from the group consisting of the compound and a salt thereof as an active ingredient.

##STR00001##

wherein R.sup.a and R.sup.b each independently represent a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; X.sup.1 and X.sup.2 each independently represent a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; X.sup.3 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or a halogeno group; X.sup.4 represents a hydrogen atom or a halogeno group; R.sup.2 represents a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; Q represents a group represented by a formula (Q1), or the like; and in the formula (Q1), an asterisk (*) indicates a bonding position with an R.sup.a-substituted nitrogen atom, and each R.sup.1 independently represents a hydrogen atom or a substituted or unsubstituted C.sub.1-6 alkyl group.

A compound represented by a formula (I) or a salt thereof; and a herbicide containing at least one selected from the group consisting of the compound and a salt thereof as an active ingredient.

##STR00001##

wherein R.sup.a and R.sup.b each independently represent a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; X.sup.1 and X.sup.2 each independently represent a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; X.sup.3 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, or a halogeno group; X.sup.4 represents a hydrogen atom or a halogeno group; R.sup.2 represents a substituted or unsubstituted C.sub.1-6 alkyl group, or the like; Q represents a group represented by a formula (Q1), or the like; and in the formula (Q1), an asterisk (*) indicates a bonding position with an R.sup.a-substituted nitrogen atom, and each R.sup.1 independently represents a hydrogen atom or a substituted or unsubstituted C.sub.1-6 alkyl group.

The present invention provides compounds, compositions thereof, and methods of using the same.

Benzoylamides of the general formula (I) are described as herbicides.

##STR00001##

In this formula (I), X, R and R.sup.a represent radicals such as alkyl, cycloalkyl and halogen. Q represents a five-membered heterocycle.

There are described isophthalamides of the general formula (I) as herbicides.

##STR00001##

In this formula (I) X and Y are radicals such as hydrogen, alkyl and halogen. Z.sup.1 and Z.sup.2 are radicals such as alkyl, cycloalkyl and phenyl. Q is a heterocyclic ring such as tetrazolyl.