The invention relates to a computer-implemented method (10) for determining the blood volume flow (I.sub.BI) through a portion (90.sub.i, i=1, 2, 3, . . . ) of a blood vessel (88) in an operating region (36) using a fluorophore. A plurality of images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ) are provided, which are based on fluorescent light in the form of light having wavelengths lying within a fluorescence spectrum of the fluorophore, and which show the portion (90.sub.i) of the blood vessel (88) at different recording times (t.sub.1, t.sub.2, t.sub.3, t.sub.4, . . . ). By processing at least one of the provided images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ), a diameter (D) and a length (L) of the portion (90.sub.i) of the blood vessel (88) and also a time interval for a propagation of the fluorophore through the portion (90.sub.i) of the blood vessel (88) are determined, which time interval describes a characteristic transit time (τ) for the fluorophore in the portion (90.sub.i) of the blood vessel (88), in which a blood vessel model (M.sub.B.sup.Q) for the portion (90.sub.i) of the blood vessel (88) is specified, which blood vessel model describes the portion (90.sub.i) of the blood vessel (88) as a flow channel (94) having a length (L), having a wall (95) with a wall thickness (d), and having a free cross section Q. A fluid flow model M.sub.F.sup.Q for the blood vessel model (M.sub.B.sup.Q) is assumed, which fluid flow model describes a local flow velocity (122) at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), and a fluorescent light model M.sub.L.sup.Q is assumed, which describes a spatial probability density for the intensity of the remitted light at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which light is emitted by a fluid, which is mixed with fluorophore and flows through the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), when said fluid is irradiated with fluorescence excitation light. The blood volume flow (I.sub.BI) is determined as a fluid flow guided through the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which fluid flow is calculated from the length (L) and the diameter (D) of the portion (90.sub.i) of the blood vessel (88) and from the characteristic transit time (τ) for the fluorophore in t

A medical implant includes a sensor that detects electromagnetic waves; and a data transmission unit that can wirelessly transmit data supplied by the sensor to a receiving unit.

The present invention is directed to a system and method for performing tissue, preferably bone tissue manipulation. The system and method may include implanting markers on opposite sides of a bone, fractured bone or tissue to facilitate bone or tissue manipulation, preferably in-situ closed fracture reduction. The markers are preferably configured to be detected by one or more devices, such as, for example, a detection device so that the detection device can determine the relative relationship of the markers. The markers may also be capable of transmitting and receiving signals. An image may be captured of the bone or tissue and the attached markers. From the captured image, the orientation of each marker relative to the bone fragment may be determined. Next, the captured image may be manipulated in a virtual or simulated environment until a desired restored orientation has been achieved. The orientation of the markers in the desired restored orientation may then be determined. The desired relationship between markers may then be programmed into, for example, the detection device. Next, actual physical reduction and/or manipulation of the bone may begin. During the manipulation procedure, the orientation of the markers may be continuously monitored and when the markers substantially align with the virtual or simulated orientation of the markers in the desired restored orientation, an indicator signal is transmitted.

According to the invention, there is provided a light-based skin treatment device comprising a treatment light source; a treatment light exit window via which, during operation, treatment light generated by the treatment light source is applied to skin of a user, wherein the treatment light exit window comprises an optically transparent material arranged to contact the skin during operation; and an imaging unit comprising an image sensor 5 arranged to generate an image of the skin during operation. The skin treatment device further comprises an optical waveguide comprising a treatment light receiving surface, an imaging light exit surface and a main surface, wherein said treatment light receiving surface is arranged to receive the treatment light so that the treatment light enters the waveguide at the treatment light receiving surface; said main surface comprises the treatment light exit 10 window and is arranged to transmit the treatment light so that the treatment light exits the waveguide at the treatment light exit window; said imaging light exit surface is arranged with respect to the main surface to receive light reflected at the main surface by total internal reflection at positions where, during operation, no skin is in contact with the main surface; said image sensor is arranged to receive from the imaging light exit surface light which is 15 guided by total internal reflection from the main surface towards the imaging light exit surface.

Temperature uncertainty maps are calculated based on a rolling window of temperature maps, which is updated as new temperature maps are generated. The rolling window mitigates the effect of transient motion during a thermal therapy procedure. A clinician or an automated control system can then update a portion of an anatomical boundary or the thermal therapy applicator center based on the temperature uncertainty map.

The present disclosure relates to a therapeutic apparatus including an MRI apparatus configured to acquire MRI data with respect to a region of interest. The MRI apparatus may include a plurality of main magnetic field coils coaxially arranged along an axis. The MRI apparatus may also include a plurality of shielding coils arranged coaxially along the axis. A current within at least one of the shielding coils may be in the same direction with a current within the main magnetic field coils.

A platform device for material excision or removal from vascular structures for either handheld or stereotactic table or robotics platform use may comprise a work element or elements configured to selectively open and close at least one articulable beak or scoopula configured to penetrate and remove intra-vascular materials or obstructions, or follow a central lumen of another device or over a wire in a longitudinal direction. Flush and vacuum tissue transport mechanisms may be incorporated as well as single or multiple arrays of image guidance elements, directional elements, ablation elements and other interventional assistance elements. A single tube or an inner sheath and an outer sheath which may be co-axially disposed relative to a work element may be configured to actuate a beak or beaks or scoopulas and provisions for simultaneous or differential beak or scoopula closing under their differential rotation may be incorporated.

The present disclosure relates to plasma generation systems which utilize plasma for semiconductor processing. The plasma generation system disclosed herein employs a hybrid matching network. The plasma generation system includes a RF generator and a matching network. The matching network includes a first-stage to perform low-Q impedance transformations during high-speed variations in impedance. The matching network includes a second-stage to perform impedance matching for high-Q impedance transformations. The matching network further includes a sensor coupled to the first-stage and the second-stage to calculate the signals that are used to engage the first and second-stages. The matching network includes a first-stage network that is agile enough to tune each state in a modulated RF waveform and a second-stage network to tune a single state in a RF modulated waveform. The plasma generation system also includes a plasma chamber coupled to the matching network.

The present disclosure describes methods of use of a composition comprising PARPi-fl to be administered to the oral cavity (e.g., via topical application to surfaces of the oral cavity) followed by imaging of the oral cavity for detection of squamous cell carcinoma of the oral cavity (e.g., in vivo, e.g., in a dental office setting or intraoperatively). The results disclosed herein show that topically applied PARPi-fl and subsequent intraoperative imaging of oral cavities can improve surgical removal of squamous cell carcinoma cells compared to healthy cells.

The disclosed system receives various physiological as well as physical information concerning a patient, and operational data from a ventilation device and medication delivery device, and provides the physiological and physical information, together with the operational data, to a neural network configured to analyze the information and data. The system receives, from the neural network, an assessment classification of the patient corresponding to at least one of a pain assessment, a sepsis assessment, and a delirium assessment of the patient based on providing to the neural network the determined physiological state of the patient, the determined physical state of the patient, the determined operational mode of the ventilator, the medication delivery information, and the received diagnostic information for the patient, and adjusts, based on the assessment classification, a ventilation parameter that influences the operational mode of a ventilator providing ventilation to the patient.