Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer.

Flame retardant mixtures comprising as component (A) 30% to 99.9% by weight of dialkylphosphinic salts of the formula (II), a and b may be the same or different and are each independently 1 to 9, and where the carbon chains may be linear, branched or cyclic and M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a protonated nitrogen base and m is 1 to 4, as component (B) 0.1% to 70% by weight of alkyl hydroxyalkylphosphinyl organylcarboxylic acid salts and/or ester salts of the formula (I) where R1CyH2y+1 with y=2 to 8, R2, R3, R4, R5, R6 are the same or different and are each independently H, CxH2x+1, CxH2x1, CxH2x3, CxH2xCO2X, CxH2x2CO2X, CxH2x4CO2X, (C2H3CO2X)u and u=0 to 1000000, CO2X, CxH2x(P(O)(OM)R1), CxH2x2(P(O)(OM)R1)(CO2X) and/or CH2CO2X, where, in the R1, R2, R3, R4, R5 and R6 groups, the carbon chains may be linear, branched or cyclic, M is Mg, Ca, Al, Sb, Sn, Ge, Fe, Ti, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, H and/or N-containing cations, x is 1 to 25, X is H, M, CzH2z+1 and z is 1 to 8, with the proviso that at least one of the R2, R3, R4, R5, R6 groups is not H, and the compounds of formula (II) and formula (I) are different compounds.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

A flame retardant sugar-derived molecule, a process for forming a flame retardant sugar-derived molecule, and an article of manufacture comprising a flame retardant sugar-derived molecule are disclosed. The flame retardant sugar-derived molecule can be synthesized from arabitol, xylitol, arabic acid, or xylonic acid obtained from a bio-based source, and can have at least one phosphoryl or phosphonyl moiety. The process for forming the flame retardant sugar-derived molecule can include reacting arabitol, xylitol, arabic acid, or xylonic acid and a flame retardant phosphorus-based molecule to form the flame retardant sugar-derived molecule.

Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.

The invention relates to agriculture, and specifically to regulators of plant growth and development that can be used for the pre-sowing treatment of cereal crop seeds and are in the form of bis(oxymethyl)phosphinic acid and biogenic metal salts thereof with the general formula (I) Me.sup.n[OP(O)(CH.sub.2OH).sub.2].sub.1, where n may be 1 or 2 and Me may be any of the following: H, Na, Ca, Mg, Co, Cu, Zn, Mn. The claimed compounds of formula I are effective regulators of plant growth and development when acting in concentrations of 1.Math.10.sup.7-1.Math.10.sup.12%. Pre-sowing treatment of the seeds of cereal crops, namely wheat, corn and rice, by means of the claimed compounds increases germination energy and germination capacity up to 13%, also increases plant vigor, and rootlet and shoot lengths increase up to 36%. Crop harvests increase and the quality of the resulting grain improves, which expands the range of effective, environmentally friendly plant growth and development regulators that act at the level of natural phytohormones.

Provided are: a water-soluble composition which has excellent storage stability and is adaptable to a wide range of light sources and capable of forming a highly fine pattern; a method of producing a cured product of the same; a cured product of the same; and an acylphosphinate. The water-soluble composition contains: an acylphosphinate (A) represented by Formula (I) below, wherein X.sup.1 represents an aryl group having 6 to 15 carbon atoms; X.sup.2 represents a linear alkyl group having 1 to 8 carbon atoms or the like; A.sup.m+ represents an alkali metal ion or the like; and m represents a number of 1 to 3; and a compound (B) having a group represented by Formula (II) below, wherein R.sup.1 represents a hydrogen atom or the like; Z.sup.1 represents an oxygen atom or the like; R.sup.2 represents a hydrogen atom or the like; Z.sup.2 represents an alkylene group having 1 to 6 carbon atoms; n represents a number of 0 to 30; * means a bond; and, when the compound (B) has plural groups represented by Formula (II), plural R.sup.1s, Z.sup.1s, Z.sup.2s and n's are each optionally the same or different.

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