Azole tripeptides may function as vasodilators. These compounds may contain three azole groups connected in a peptide-like structure. The azole groups may be monocyclic or fused bicyclic heteroaryl groups. Each azole group may be substituted or unsubstituted. The compounds may include various end cap moieties. A pharmaceutical composition may include an azole tripeptide compound and a pharmaceutically acceptable carrier. Methods of vasodilation may include administering an azole tripeptide compound to a subject in a therapeutically effective amount. The administration may cause vasodilation in the subject. The vasodilation may provide treatment for various conditions. The azole tripeptide compounds may be synthesized through multi-step chemical processes.