An image sensor assembly includes at least one upconverter configured to detect light in a NIR waveband that is received from an object to be imaged and generate, based on the detected light, upconverted light that is outside of the NIR waveband; and at least one image sensor configured to detect the upconverted light.

A tissue detection system includes a probe having a body and an emission optical fiber extending from an input end through the probe body to an output end at a distal end portion of the probe body. The emission optical fiber defines a Numerical Aperture (NA). The tissue detection system further includes an emitter configured to output electromagnetic radiation and an optical coupler optically coupling the emitter with the input end of the emission optical fiber such that, in response to receiving the output from the emitter, electromagnetic radiation is input to the input end of the emission optical fiber. The optical coupler modifies the electromagnetic radiation such that the electromagnetic radiation input to the input end of the emission optical fiber defines an NA about equal to or less than the NA of the emission optical fiber.

A system and a method is disclosed for continuously identifying blood vessels in tissue during fluorescence imaging. Continuously measuring and assessing hemodynamics in tissue in medical procedures using fluorescence imaging may include the administration of the fluorescent agent that is controlled and automated and thereby identifying, mapping and visualizing blood vessels in the tissue. One embodiment relates a computer implemented method for identifying blood vessels in tissue of a subject, e.g. during a medical procedure, the method including the steps of continuously acquiring fluorescence images of the tissue wherein a fluorescent signal is oscillating with a predetermined pattern, and analysing the fluorescence images and the associated oscillating signal thereby continuously identifying blood vessels in the tissue.

The present invention relates to a method and a device for quantitatively detecting the presence or absence of an analyte in a liquid sample, comprising the steps of providing a set of parts comprising a container for collecting a liquid sample material, and a filter material and a detection device comprising a reaction liquid, thereafter adding a metered amount of liquid sample material to the container, thereafter transferring the metered amount of liquid sample material from the container to the filter material, thereafter contacting the filter material containing the metered amount of sample material with the reaction liquid and mixing the reaction liquid and the filter material, thereby obtaining a detection liquid, thereafter measuring the transmission of electromagnetic radiation at one or more wavelengths through the detection liquid and/or the emission of electromagnetic radiation at one or more wavelengths from the detection liquid and detecting the amount of analyte in the sample by comparing the results obtained in step e. with an internal standard, the method being characterised in that the metered amount of sample is transferred from the container to the filter material by use of capillary forces.

Disclosed are methods and digital tools for deriving tooth condition information for a patient's teeth, for populating a digital dental chart with derived tooth condition information, and for generating an electronic data record containing such information.

The present invention is a Miniature Vein Enhancer, for use in imaging the subcutaneous veins of a target area of a patient by a practitioner. The miniature vein enhancer includes a Miniature Projection Head that is secured to a tourniquet, where the tourniquet may be mounted to the bicep of a patient. The Miniature Projection Head includes a housing, and apparatus that images subcutaneous veins of the target area, and projects the image(s) of the veins onto the target area to overlie the subcutaneous veins, which aids the practitioner in pinpointing a vein location for a venipuncture procedure such as an intravenous drip, blood test, and the like.

Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.

Hyperspectral videostroboscopy imaging is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, or from about 900 nm to about 1000 nm.

A fluorescence imaging system is configured to generate a video image onto a display. The system includes a light source for emitting infrared light and white light, an infrared image sensor for capturing infrared image data, and a white light image sensor for capturing white light image data. Data processing hardware performs operations that include filtering the infrared image data with a first digital finite impulse response (FIR) filter configured to produce a magnitude response of zero at a horizontal Nyquist frequency and a vertical Nyquist frequency. The operations also include filtering the infrared image data with a second digital FIR filter configured with a phase response to spatially align the white light image data with the infrared image data. The operations also include combining the white light image data and the infrared image data into combined image data and transmitting the combined image data to the display.

Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.