There is provided a computer implemented method for generating a three dimensional (3D) image based of fluorescent illumination, comprising: receiving in parallel by each of at least three imaging sensors positioned at a respective parallax towards an object having a plurality of regions with fluorescent illumination therein, a respective sequence of a plurality of images including fluorescent illumination of the plurality of regions, each of the plurality of images separated by an interval of time; analyzing the respective sequences, to create a volume-dataset indicative of the depth of each respective region of the plurality of regions; and generating a 3D image according to the volume-dataset.

A medical supporting arm according to the present disclosure includes a supporting arm and a calculation unit. The supporting arm supports an oblique-viewing endoscope. The calculation unit calculates a rotation angle of the oblique-viewing endoscope around an axis in a longitudinal direction, and an insertion amount of the oblique-viewing endoscope into a human body on the basis of a first expression that defines coordinates of a subject in a coordinate system in which an insertion opening allowing the oblique-viewing endo scope to be inserted into the human body serves as an origin, and a second expression that defines the coordinates of the subject positioned in an optical axis direction of an objective lens disposed at a distal end of the oblique-viewing endoscope in a coordinate system in which the distal end of the oblique-viewing endoscope serves as an origin.

Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.

A solution is proposed for assisting a medical procedure. A corresponding method comprises acquiring a luminescence image (205F), based on a luminescence light, and an auxiliary image (205R), based on an auxiliary light different from this luminescence light, of a field of view (103); the field of view (103) contains a region of interest comprising a target body of the medical procedure (containing a luminescence substance) and one or more foreign objects. An auxiliary informative region (210Ri) representative of the region of interest without the foreign objects is identified in the auxiliary image (205R) according to its content, and a luminescence informative region (210Fi) is identified in the luminescence image (205F) according to the auxiliary informative region (210Ri). The luminescence image (205F) is processed limited to the luminescence informative region (210Fi) for facilitating an identification of a representation of the target body therein. A computer program and a corresponding computer program product for implementing the method are also proposed. Moreover, a computing device for performing the method and an imaging system comprising it are proposed. A medical procedure based on the same solution is further proposed.

An imaging system may include: a first light source configured to emit a first source spectrum of collimated light; a second light source configured to emit a second source spectrum of light; a probe head configured to direct the first source spectrum and the second source spectrum toward tissue in an oral cavity and to collect a first feedback spectrum of light and a second feedback spectrum of light; an interferometry sub-system to generate an optical feedback signal using the first source spectrum; at least one optical sensor array for receiving the optical feedback signal and the second feedback spectrum; and at least one programmable processor to generate: a first diagnostic image of the tissue using the optical feedback signal; a second diagnostic image of the tissue using the second feedback spectrum; and a third diagnostic image from a combination of the first diagnostic image and the second diagnostic image.

The endoscope has an insertion portion, an imaging unit, and a member formed in a given dimension. The insertion portion has an apical portion, an actively curvable portion, and a treatment device channel. The actively curvable portion is located on the proximal side of the apical portion. The treatment device channel is positioned along the longitudinal axis of the insertion portion. The insertion portion is formed of resin. One or more radiopaque members, formed of knowns dimensions, are coated on a surface of the insertion portion or placed in, buried or covered laterally in the insertion portion. The X-ray transmittance of the radiopaque members is different from the X-ray transmittance of the resin forming the insertion portion.

A computer-implemented method for predicting digital images in the form of a digital fluorescence representation together with a further derived representation by means of a combined machine learning system is described. The method comprises providing a first digital image of a tissue sample that was recorded under white light by means of a microsurgical optical system with a digital image recording unit, and predicting a second digital image of the tissue sample in a fluorescence representation and a further representation, which has optical indications about diseased tissue elements. This is done by means of a previously trained combined machine learning system comprising a trained combined machine learning model for predicting the second digital image of the tissue sample in the fluorescence representation and the further representation.

In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.

Systems, methods, and devices for laser scanning in a light deficient environment. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller comprising a processor in electrical communication with the image sensor and the emitter, wherein the controller synchronizes timing of the pulses of electromagnetic radiation during a blanking period of the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises a laser scanning pattern.

Offset illumination using multiple emitters in a fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The emitter comprises a first emitter and a second emitter for emitting different wavelengths of electromagnetic radiation. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.