Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.

The disclosure provides for a systems and methods for monitoring uterine contractions of a uterus of a mammal by reconstructing three-dimensional images of uterine surface electrical activity based on a noninvasively obtained body-uterus geometry and a plurality of body surface electrical potential maps.

Systems, apparatuses, and methods are described for 3D luminescence imaging, by identifying a preferred optical pair and optimizing a scanned image using the preferred optical pair. An optimal filter pair may be selected from a list of two or more optical filters. An acceptable threshold of information may be obtained using a subset of the list of two or more optical filters (e.g., an optimal filter pair). An imaging device may be configured with the optimal filter pair to produce a pair of luminescence images of a target sample. In addition, luminescence images may be pre-processed to reduce the time-cost of conventional processing techniques of luminescence images. One or more computing devices may generate initial prior data based on a pair of luminescence images. An output may include one or more output luminescent sources that have been refined and/or optimized from the initial prior data.

Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

A computer assisted orthopedic surgery system for soft tissue balancing and implant planning is provided. The system includes a three dimensional position tracking system, a robot, a display, and a computer. The computer is operatively in communication with the three dimensional position tracking system, the robot and the display. The computer includes a processor configured to acquire native gap data between a first bone and a second bone of a joint, simulate implant gap data between a first implant model on a first bone model of the first bone and a second implant model on a second bone model of the second bone of the joint based on an implant planning criteria to calculate a plurality of implant gap profiles, determine a best match of the plurality of implant gap profiles to the native gap profile to determine an optimized implant plan, and output the optimized implant plan.

Devices and methods are described for a minimally invasive procedure offering immediate relief of brain compression and prevention of subdural hematoma re-accumulation. For example, this disclosure describes devices and methods for embolization of bleeding branch vessels of the middle meningeal artery and subdural hematoma drainage in a single endovascular intervention using multimodal catheter-based technology.

A target image to be corrected is generated by arranging partial images acquired by scanning a tissue of a living body with light and temporally continuously receiving the light from the tissue. A processor of a medical image processing device performs detecting position shift amounts, acquiring a component, and correcting. In the process of detecting position shift amounts, the processor detects the position shift amounts between the partial images (S3). In the process of acquiring, the processor acquires an assumed result of at least one of a component in the position shift amount caused by movement of the tissue, and a component in the position shift amount caused by a shape of the tissue (S4). In the process of correcting, the processor corrects a position of each of the partial images based on the component in the position shift amount (S7).

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

A computer implemented method for assessing an arterio-venous malformation (AVM) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the AVM, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the AVM, by performing computer simulations of blood flow through the one or more blood vessels associated with the AVM in the patient-specific model.

A method and apparatus for dual mode imaging uses an ultrasonic detection device, a diffuse optical tomography (DOT) detection device for imaging a breast. The DOT detection device is configured to detect changes of tissue blood oxygen. A host machine in communication with the ultrasonic detection device and the DOT detection device is used for imaging the breast by simultaneously generating functional images and structural information images of the breast based on the imaging.