A package (1) for a fluid formulation (2) to be delivered as a spray or a jet of droplets to an eye (4), comprising an enclosed container (5) a storage recess (6) containing a fluid formulation (2); and a delivery recess (7), adjacent to the storage recess (6). The storage recess (6) and the delivery recess (7) are separated by a fluid barrier (8). Package (1) further comprises a matrix of holes (9), for generating the spray and/or jet of droplets, the matrix of holes (9) opening into the delivery recess (7). The storage recess (6) is configured to expel, by application of an impulse thereto, a dose of fluid formulation (2). The matrix of holes (9) is configured to steer the spray and/or jet of droplets to the target area (3) on the eye (4). Also provided is a device (20) for delivery of the fluid formulation, and a method for delivering the fluid formulation (2) as a spray or a jet of droplets to an eye (4) of a user.

A wearable device for detecting and/or measuring physiological information from a subject includes a housing, at least one optical emitter supported by the housing, at least one optical detector supported by the housing, a first light guide supported by the housing, a second light guide supported by the housing, a motion sensor supported by the housing, and a processor supported by the housing. The processor is configured to calculate footsteps, distinguish footsteps from heart beats, and to remove footstep motion artifacts from signals produced by the at least one optical detector. Also, the processor is configured to process signals produced by the at least one optical detector to determine subject heart rate and to produce integrity data about the subject heart rate. The process is further configured to generate a multiplexed output serial data string comprising the subject heart rate and the integrity data.

A system and method for compensation of angular distortions in a system utilizing light emitters and light sensors disposed on non-parallel jaws may include determining a first point at a first side of a region of interest and a second point at a second side of the region of interest, determining a linear curve including the first and second points, and utilizing the linear curve to remove the angular distortion from the region of interest between the first and second points, A system and method for compensation of angular distortions may alternatively include modeling a non-pulsatile illumination pattern according to the intensities of individual emitters, comparing the pattern according to the model against a non-pulsatile illumination pattern detected using the light sensors, and varying the intensities of the individual emitters based on the comparison until angular distortion has been removed.

A method for obtaining a near-infrared spectroscopy (fNIRS) cerebral signal in a subject includes: placing a near-infrared emitter and respective proximal and distal near-infrared detectors on a skin of a head of a subject; during a baseline recording stage with the subject in resting-state, record near-infrared signals, the recorded signals including a baseline deep-signal and a baseline shallow-signal; calculate a scaling factor between amplitudes of the baseline deep-signal and the baseline shallow-signal at a given task-frequency; with the subject undergoing a cyclic cerebral stimulation at the task-frequency during a stimulation recording stage, record near-infrared signals, the recorded signals comprising a shallow-signal and a deep-signal; and applying the scaling factor to the shallow-signal, calculating the cerebral signal at the task-frequency as a difference between the deep-signal and the scaled shallow-signal, at the task-frequency.

Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

A method for evaluating reading comprehension is provided. The method includes the steps of providing at least one printed passage of text; providing a test subject, the test subject wearing a device for measuring brain frontal lobe usage; requiring the test subject to read the printed passage; providing a question based on the printed passage for the test subject to answer; and determining whether the device measures brain frontal lobe usage. A system for performing the method is also provided.

Systems, devices and methods for managing personal activities and health regimens are provided. In some aspects, a control system comprising specialized computer hardware and software provides instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) to a user, based on such a health regimen. In additional aspects, such instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) are also based on data from specialized sensors tracking a user's personal activities within a personal activity space. In some aspects, instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) are adjusted in real time, based on input from multiple users. In one example, a partial giveback reward is provided to a user, in which part of a regimen goal that is exceeded is provided back to the user as one such incentive.

The present disclosure provides a non-contact neck-based respiratory and pulse signal detection method and apparatus, and an imaging device. The method includes: acquiring 3D morphological information of a neck of a human body in real-time; and acquiring a respiratory signal and an electrocardiogram signal of the human body on the basis of the 3D morphological information of the neck.

A non-invasive optical measurement system comprises a two-dimensional array of photonic integrated circuits (PICs) mechanically coupled to each other. Each PIC is configured for emitting sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure. Each PIC is further configured for detecting the signal light. The non-invasive optical measurement system further comprises processing circuitry configured for analyzing the detected signal light from each of the PICs, and based on this analysis, determining an occurrence and a three-dimensional spatial location of the physiological event in the anatomical structure.

Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.