A system or device includes a member structure, a plurality of flexible members, and a plurality of tips disposed at ends of the flexible members. The member structure includes an ultrasonic emitter configured to emit an ultrasonic imaging signal. The plurality of flexible members are coupled to the member structure. The plurality of tips are disposed at ends of the flexible members. At least one tip of the plurality of tips includes an image sensor configured to receive an infrared exit signal.

A device includes a sensor, a coherent infrared illumination source and optics to direct an infrared reference beam to the sensor. The sensor is positioned to capture an image of an interference signal generated by an interference of the infrared reference beam and a wavelength-shifted exit signal. The wavelength-shifted exit signal propagates through the optics before interfering with the infrared reference beam.

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (TOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

An acousto-optic transducer comprises a graphene resonator, a substrate, an entry window and an exit window. The graphene resonator bears at least one donor molecule. The substrate bears at least one acceptor molecule. The graphene resonator is responsive to sound to bring the at least one donor molecule within range of the at least one acceptor molecule for Frster resonance energy transfer from the at least one donor molecule to the at least one acceptor molecule to take place. The entry window is arranged to permit incoming light to fall on the at least one donor molecule. The exit window is arranged to allow light emitted by the at least one acceptor molecule to leave the acousto-optic transducer. Thus, the acousto-optic transducer can function as a passive device using only energy derived from ambient light to convert sound into light.

Provided is an ultrasound therapy system for treating a joint by providing a focused ultrasound wave to a bone surface as an affected part, and which has a temperature monitoring function for controlling irradiation intensity. The ultrasound therapy system includes a focused ultrasound wave providing unit provided on skin and configured to radiate the focused ultrasound wave to the affected part, and a temperature detecting unit configured to measure a temperature of the affected part. The temperature detecting unit includes an electromagnetic wave measuring unit configured to measure intensity of an electromagnetic wave radiated from the bone surface, and an analyzing unit configured to analyze change of the electromagnetic wave of the electromagnetic wave measuring unit to provide the temperature of the affected part. The analyzing unit provides the temperature of the affected part from electromagnetic change between a pair of reference waves for electromagnetic change which correspond to a pair of an emitted wave of the focused ultrasound wave provided from the focused ultrasound wave providing unit and a reflected wave from the bone surface and which are measured at the electromagnetic wave measuring unit with a time delay.

The length of an optical fiber from a portion aligned with the rear end of an insertion needle to a fixing portion is a length obtained by adding a predetermined extra length to a linear distance between the rear end of the insertion needle in a case where the insertion needle is located at a protruding position (insertion position) and an optical fiber fixing position of a grip portion. There is provided a fiber feeding adjustment mechanism that suspends the optical fiber with a first suspension portion and a second suspension portion so as to make a detour in a state in which there is no slack, and changes the detour length continuously according to the movement of the insertion needle in a case where the insertion needle moves between the retracted position and the protruding position, thereby maintaining a state in which the optical fiber is suspended without slack.

In a non-invasive optical detection system and method, sample light is delivered into a scattering medium. A first portion of the sample light passing through a volume of interest exits the scattering medium as signal light, and a second portion of the sample light passing through a volume of non-interest exits the scattering medium as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to create an interference light pattern having a holographic beat component. Ultrasound is emitted into the volume of non-interest in a manner that decorrelates the background light of the sample light pattern from the holographic beat component. The holographic beat component is detected during the measurement period. An optical parameter of the volume of interest is determined based on the detected holographic beat component.

In one embodiment, a superlens is used to sub-diffraction-limit focus a magnetic field within a volume. A local magnetic field intensity maximum, or hotspot, is thereby created that is focused in two spatial directions substantially parallel to the superlens. The hotspot extends from the superlens through one or more coplanar layers of the volume. An electric field is superimposed over the magnetic field within the volume to be imaged. The superposition of electric and magnetic fields induces localized Lorentz forces. The modulation of the magnetic and/or electric field causes the portion of the volume in the hotspot to vibrate and emit acoustic signals at a frequency suitable for acoustic imaging. An acoustic transducer receives the emitted acoustic signals. The location from which the acoustic signals are emitted is constrained in two dimensions by the superlens. Time-gating the acoustic signals received from the hotspot is used to localize the received acoustic signals in the third dimension.

An acousto-optic imaging method in which light waves and unfocused acoustic waves having various directions of propagation m are emitted in a medium, by spatially modulating the amplitude of the ultrasonic transducers of an array of transducers according to several periodic spatial amplitude modulations j, and the resulting optical signal S.sub.mj(t) is captured. For each direction of propagation m, the signals S.sub.mj(t) are spatially demodulated in order to determine a signal S.sub.m(t) used to reconstruct the image of the medium.

Certain implementations of the disclosed technology may include active marker devices, retrofits, systems, and methods for determining the position of interventional devices under MRI. A marker device is provided that utilizes an optical fiber, an acousto-optical sensor region that includes an electro-mechanical conversion assembly, and one or more antenna(e) The one or more antennae are configured to receive MRI radio-frequency (RF) electromagnetic energy and produce a corresponding electrical signal corresponding to the position. The acousto-optical sensor region may include a resonator and may be modulated by acoustic waves generated responsive to the electrical signal received from the one or more antennae The acousto-optical sensor region may be interrogated by light via the optical fiber to determine the position of the device for providing an active marker in the MRI image.