Provided herein are methods and systems for making patient-specific therapy recommendations of a combination of any two or more therapies selected from a lipid-lowering therapy, an anti-inflammatory therapy for patients with known or suspected cardiovascular disease, such as atherosclerosis.

Method for ameliorating secondary pulmonary hypertension in a patient including determining a pulmonary vascular resistance (PVR) of the patient suffering from secondary pulmonary hypertension; assessing a change in the PVR in response to a selection treatment; and treating the patient with a pulmonary artery manipulation device to provide pulmonary artery denervation if the patient is determined to suffer from fixed PH, thereby ameliorating the secondary pulmonary hypertension of the patient.

Embodiments of the present disclosure include a method, device and computer readable medium involving receiving image data of one or more coronary arteries, generating a binary segmentation indicating presence of calcium in the one or more coronary arteries from the image data, generating a branch density of the one or more coronary arteries, and assigning a coronary artery label from the branch density to the binary segmentation such that at least one indication of presence of calcium of the binary segmentation is labeled as present in a specific one of the one or more coronary arteries.

A method for reproducing a lumen curve to a given tolerance in at least one image in optical coherence tomography (OCT). Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, cardio applications, and being obtained via one or more optical instruments, such as, but not limited to, catheters. The method may include obtaining a set of original points of the curve that correspond to measurements from an optical imaging device. Filtering the set of original points using at least one criteria to obtain a subset of original points. The method may also include determining if the subset of original points is less than a predetermined threshold and adjusting the at least one criteria to increase an amount of original points included in the subset of original points when it is determined that the subset of original points is less than the predetermined threshold.

Offset illumination using multiple emitters in a fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The emitter comprises a first emitter and a second emitter for emitting different wavelengths of electromagnetic radiation. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.

A biological information displaying apparatus according to an embodiment includes a picture obtaining apparatus and a processor. The picture obtaining apparatus obtains a picture signal of a predetermined site of a subject as a moving image. The processor generates a hue moving image by extracting a luminance or an image-based photoplethysmogram (iPPG) related to a pulse wave for each pixel of the moving image and assigning a hue in accordance with a value of luminance information or iPPG information. The processor displays the generated hue moving image such that the hue moving image is superimposed on an image of the subject.

A control unit (12) and method for deriving a measure of arterial compliance based on an acquired arterial volume variation signal and measured diastolic and systolic blood pressure measurements. An oscillometric blood pressure measurement device is used to obtain a first signal representative of arterial volume variations and to obtain blood pressure measurements. Both are measured as an applied pressure to an artery is varied by the oscillometric blood pressure measurement device. The first signal is processed to compile a dataset of values, ΔV, representative of the change in the arterial volume for set step changes, ΔP, in applied pressure, at different transmural pressure values. This set of values is numerically integrated to derive a function of arterial volume with transmural pressure. This function is differentiated to thereby derive a function of arterial compliance with transmural pressure.

A system is provided for deployment of a sensor in a blood vessel comprising: an expandable sensor; at least one anchor element attached to the sensor; an expandable element configured within the sensor such that, in use, expansion of the expandable element causes the sensor to radially expand to fix the at least one anchor element in a wall of the blood vessel.

A system (100) includes a computer readable storage medium (122) with computer executable instructions (124), including: a biophysical simulator component (126) configured to determine a fractional flow reserve value via simulation and a traffic light engine (128) configured to track a user-interaction with the computing system at one or more points of the simulation to determine the fractional flow reserve value. A processor (120) is configured to execute the biophysical simulator component to determine the fractional flow reserve value and configured to execute the traffic light engine to track the user-interaction with respect to determining the fractional flow reserve value and provide a warning in response to determining there is a potential incorrect interaction. A display is configured to display the warning requesting verification to proceed with the simulation from the point, wherein the simulation is resumed only in response to the processor receiving the requested verification.

A soft, flexible microtube sensor and associated method of sensing force are described. A liquid metallic alloy is sealed within a microtube as thin as a strand of human hair to form the physical force sensing mechanism. The sensor is hardly distinguishable with the naked eye, and can be used for the continuous biomonitoring of physiological signals, such as unobtrusive pulse monitoring. Also described is a method of fabricating the microtube sensor and wearable devices incorporating one or more microtube sensors.