Disclosed herein are methods and systems for clinical practice of medical imaging on patients with metal-containing devices, such as implanted cardiac devices. In particular, Disclosed herein are methods and systems for improved late gadolinium enhancement (LGE) MRI for assessing myocardial viability for patients with implanted cardiac devices, i.e., cardiac pacemakers and implantable cardiac defibrillators.

A system having a processor obtain a digital hemodynamic data from a hemodynamic sensor, obtain one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data, derive differential parameters based on the one or more vital sign parameters, generate combinatorial parameters using the one or more vital sign parameters and the differential parameters, determine a risk score corresponding to a probability of a future hypotension event for the living subject based on a weighted combination of a plurality of hypotension profiling parameters including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters, and invoke a sensory alarm if the risk score satisfies a predetermined risk criterion.

A system for measuring haemodynamic parameters relating to a subject, the system comprising a DRS probe, a microscope probe, and a cap for use at a respective distal end of each of the probes, one at a time. The cap comprises a rigid flat contact surface for contact with a body surface of a subject, the contact surface comprising an aperture arranged such that, in use, the aperture is optically aligned with the optical probe. A rigid side wall surrounds the contact surface, defining a closed end and an open end, the closed end being formed by the contact surface. The open end is arranged to receive the probe in use. The side wall is arranged such that, in use, the cap is held in abutment against the probe. A securing portion is arranged to removably secure the cap to the probe.

A method of estimating a value associated with heart wall tension. The method comprises: using motion data recorded with a sensor in communication with the heart to identify motion in the heart; and estimating a value associated with heart wall tension based on the identified motion in the heart. The motion in the heart that forms the basis of the estimation may be a vibration in the heart wall. A heat monitoring system for carrying out the method of estimating a value associated with heart wall tension comprises a sensor configured to be placed in communication with the heart in order to identify motion in the heart; and a data processing device arranged to receive motion data from the sensor and to then carry out the steps of the method.

Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as blood pressure, cardiac output, stroke volume and vascular tone, of a subject, and the mechanical anelastic in vivo properties of the subject's arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume; and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output from the waveforms PPW and PUW, and the quality factor of the artery based upon the calculations. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system and methods may be configured to monitor at least one input signal detected at a coronary sinus and thereby execute a process for determining a satisfactory time period for the occlusion of the coronary sinus. In further embodiments, after the occlusion of the coronary sinus is released, the control system can be configured to select the duration of the release phase before the starting the next occlusion cycle.

Systems and methods are provided for enhanced heart medical imaging operations, particularly as by incorporating use of artificial intelligence (AI) based fetal heart functional analysis and/or real-time and automatic ejection fraction (EF) measurement and analysis.

The various embodiments of the present invention provide a system and method for a fully mobile, non-invasive, continuous system for monitoring the cardiovascular and musculoskeletal health of an individual during exercise, and for administering a protocol for ischemic pre-conditioning. The system includes a wearable devices affixed on the user with a chest strap, coupled with an application running on a computing device (smartphone/smartwatch), which performs various computations on the wearable device, and allows the user to get real time alerts during exercise, by way of vibrations or audio messages or notifications on the gateway device, to guide them through a protocol for ischemic pre-conditioning.

An exemplary embodiment of the present disclosure provides systems and methods for non-invasively measuring blood pressure, the system and methods comprise a wearable device having a first surface, a first sensor positioned on the first surface of the wearable device, the first sensor configured to receive a first signal, wherein the first signal is indicative of a first blood-volume change in a first vessel of a subject, a second sensor positioned within the wearable device, the second sensor configured to receive a second signal, wherein the second signal is indicative of a cardiac mechanical motion of the subject, and a processor positioned within the wearable device, the processor configured to generate an output based at least on the first signal and the second signal, the output representing a blood pressure measurement of the subject.

The invention relates to a method for determining the microvascular resistance reserve, MRR, in the myocardium perfused by a normal or a stenotic coronary artery of a human patient, which method comprises the step of during rest condition of the patient: measuring the blood flow, Q.sub.rest, through the coronary artery; and further comprising the step of during rest condition or during maximum hyperemia of the patient: measuring the blood pressure, P.sub.a, at a position proximal in the coronary artery or proximally of any stenosis, if present; and further comprising the steps of during maximum hyperemia of the patient: measuring the blood flow, Q.sub.max, through the coronary artery; and measuring the blood pressure, P.sub.d, at a position distal in the coronary artery or distally of any stenosis, if present, and wherein the microvascular resistance reserve, MRR, is determined by the additional step of calculating the microvascular resistance reserve as

[00001]$MRR=\frac{Q_{\max }}{Q_{\mathrm{rest}}}\frac{P_a}{P_{d,hyper}}.$