In some examples, a method includes receiving a signal indicative of a blood pressure of a patient and identifying at least one first portion of the signal comprising a first characteristic of the signal exceeding a first threshold. The method also includes identifying at least one first portion of the signal comprising a second characteristic of the signal exceeding a second threshold, the first characteristic being different than the second characteristic. The method further includes determining a filtered signal indicative of the blood pressure of the patient by excluding the at least one first portion and the at least one second portion from the signal. The method includes determining a set of mean arterial pressure values based on the filtered signal and determining an autoregulation status of the patient based on the set of mean arterial pressure values.

Systems and methods for assessing a cardiac arrhythmia risk of a patient, such as a risk for developing atrial fibrillation, are disclosed. An exemplary medical-device system includes an arrhythmia predictor circuit configured to receive physiologic information of a patient, and in an absence of atrial tachyarrhythmia in the patient, determine a risk of the patient developing future atrial tachyarrhythmia using the physiologic information. In accordance with the arrhythmia risk indication, the system can generate an alert, or initiate more aggressive monitoring of a patient identified as having a high atrial tachyarrhythmia risk.

The invention provides a ghrelin molecule for use in the treatment and/or prophylaxis of Acute Heart Failure (AHF) in an individual, as well as corresponding methods and uses. The invention further provides associated compositions and kits of parts, for use in the treatment and/or prophylaxis of AHF in an individual.

Computer-implemented method of detecting parameters indicative of a variation of activation of the sympathetic nervous system and of a variation of activation of the parasympathetic nervous system in a subject in a transition from a basal condition to a perturbed condition, comprising the calculation of the power ratio between the powers in the LF and HF bands of the power spectra of the systolic time interval and the diastolic time interval.

The invention relates to a system for challenging the pericardial space, to provide an indication of the risk of cardiac tamponade in a patient, as well as methods for diagnosis of, and determination of the extent of, a tamponade, and treating a patient in whom there is a detected cardiac tamponade.

A health sensor system and method can include a wearable non-invasive biosensor for capturing cardiac waveform signals such as electrocardiogram (ECG) signals and composite vibration objects over one or more channels, one or more processors operatively coupled to the wearable non-invasive biosensor, and memory having computer instructions which causes the system to perform certain operations. In some embodiments, the operations can include powering the health sensor system in response to receiving a radio frequency signal using a near field communication protocol, monitoring pulmonary artery pressures based on cardiac time intervals during a period when the health sensor system is powered by the radio frequency signal, performing a heart and lung function assessment based on the monitoring of the pulmonary artery pressures, and presenting the heart and lung function assessment. In some embodiments, the biosensor can be a single NFC patch biosensor.

A system for noninvasive extraction, identification, and marking of the heart valve signals to evaluate and monitor elevated left ventricular end-diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP) using at rest assessment of hemodynamic performance, based on quantitative measurements of heart and lung related parameters and cardiac events for diagnostic and therapeutic purposes includes one or more signals from one or more noninvasive sensors or transducers that measure one or more physiological effects that are correlated with cardiopulmonary functions, transmission of the data to a computing device and analysis software where a trained algorithm processes the data to determine the state or condition of elevated LVEDP or PCWP and provides an output indicative of the state or condition of the analysis. The described noninvasive cardiopulmonary health assessment and monitoring systems and methods can provide effective at-home self-assessment or an integrated telehealth remote patient monitoring (RPM) system.

A method for an expert system to develop fitness training plans includes operating a dynamic exertion system to receive a rate of perceived exertion (RPE) through a user interface of a display device, combines the RPE with a movement, a movement load, and movement repetitions into movement set data, and operates a dynamic exertion algorithm. The method then displays an adjusted movement information display including the prescribed load and the prescribed movement repetitions through the user interface. The dynamic exertion algorithm generates a prescribed load and prescribed movement repetitions, determines a difference in RPE from the expected RPE through operation of a comparator, recalculates the one repetition maximum load value using the calibration and adjustment model when the difference in RPE is greater than an RPE threshold value, and generates a display control comprising the prescribed load and the prescribed movement repetitions.

Methods and systems of computing parameter values of one or more model parameters are described. The model models structural and dielectric properties of a structure in a human or an animal body. An exemplary method includes: accessing voltage measurements made at different places in the vicinity of the structure by one or more in-body field sensing electrodes in response to currents applied to one or more field supplying electrodes; and computing the parameter values by adjusting the parameter values to fit predicted voltage values to the accessed voltage measurements, wherein the predicted voltage values are predicted from the model for the currents applied to the field supplying in-body electrodes.

A stretch-measurement probe includes an elongate outer sleeve, expansion feature associated with a distal portion of the outer sleeve, and an elongate inner rod disposed at least partially within the outer sleeve. The expansion feature is configured to allow a longitudinal distance between a proximal end of the outer sleeve and the distal end of the outer sleeve to be varied.