A cerebrospinal-fluid-pressure-measuring device including a pressure gauge including a hollow cylindrical body for inserting through a skull and having a lower and upper end, and an inner surface, a membrane attached to the lower end and to move under a pressure of cerebrospinal fluid within the skull, and coils including a stationary coil disposed in the cylindrical body and connected to the inner surface so as to remain stationary, and a moving coil disposed in the cylindrical body and connected to the membrane so that the moving coil moves when the membrane moves under the pressure, one of the coils being configured as a transmitting coil and another of the coils being configured as a receiving coil, and a control unit to apply an input signal to the transmitting coil and receive an output signal from the receiving coil, and to generate an indication of the pressure.

Embodiments for a cerebrospinal fluid flow detector for detecting the flow of cerebrospinal fluid are disclosed. In some embodiments, the cerebrospinal fluid flow detector includes a casing with a rotatable wheel having a plurality of radially extending arms disposed therein. The rotatable wheel is in communication with a channel having a distal end in communication with an inlet port and a proximal end in communication with an outlet port such that the flow of cerebrospinal fluid through the channel causes the rotatable wheel to rotate. In some embodiments, each radially extending arm includes at least one radiopaque marker in which movement of the rotatable wheel caused by fluid flow through the channel allows an X-ray imaging apparatus to detect the difference in position of a respective radiopaque marker at multiple times caused by rotation of the rotatable wheel.

A method for predicting a cancer staging score from medical image data includes receiving patient data for a plurality of patients, where patient data for each of the plurality of patients includes one or more of an image volume of a suspected tumor in an organ, blood test data, demographic data, and ground truth tumor staging scores for the suspected tumor in the organ, extracting features from the patient data, and using the features extracted from the patient data to train a classifier to predict a cancer staging score for a new patient from one or more of an image volume of a suspected tumor in the organ, patient blood test data and patient demographic data of that new patient.

A thin-film, diaphragm based device is disclosed which can be used to perform an array of sensing and actuating operations where a very thin profile is desired, such as in millimeter, micrometer, or nanometer tight spaces.

A system for detecting a blood vessel rupture is disclosed. The system includes a sensor assembly including a plurality of sensors, each of which is configured to detect a pressure wave through CSF and to generate a pressure signal in response thereto. The system also includes a processing device coupled to the sensor assembly. The processing device configured to analyze the pressure signal to determine a blood vessel rupture.

Embodiments for a cerebrospinal fluid flow detector for detecting the flow of cerebrospinal fluid are disclosed. In some embodiments, the cerebrospinal fluid flow detector includes a casing with a rotatable wheel having a plurality of radially extending arms disposed therein. The rotatable wheel is in communication with a channel having a distal end in communication with an inlet port and a proximal end in communication with an outlet port such that the flow of cerebrospinal fluid through the channel causes the rotatable wheel to rotate. In some embodiments, each radially extending arm includes at least one radiopaque marker in which movement of the rotatable wheel caused by fluid flow through the channel allows an X-ray imaging apparatus to detect the difference in position of a respective radiopaque marker at multiple times caused by rotation of the rotatable wheel.

Disclosed is a valve assembly operable to selectively control a flow or passage of a fluid. The valve assembly may be applied to any appropriate mechanism such as a hydrocephalus shunt, fluid draining sewage system, or tank holding system. The valve assembly disclosed may include a selected profile for various applications.

Disclosed is a valve assembly operable to selectively control a flow or passage of a fluid. The valve assembly may be applied to any appropriate mechanism such as a hydrocephalus shunt, fluid draining sewage system, or tank holding system. The valve assembly disclosed may include a selected profile for various applications.

Apparatuses and methods for measurement of flow rate of cerebrospinal fluid in a conduit are provided. The apparatus comprises a heating element mounted on the conduit, the heating element arranged for heating the CSF flowing through the conduit for generating bubbles. The apparatus further comprises two optical sensing devices mounted sequentially on the conduit and downstream from the heating element. The first optical sensing device and the second optical sensing device are separated by a predetermined device interval. Both the first and the second optical sensing devices comprise an optical emitter and an optical detector. The apparatus further comprises a processing device coupled to the optical sensing devices, wherein the signals from the optical sensing devices are transmitted to the processing device for detection of bubbles, resulting in the detection of the flow velocity. The bubble size can be optimized by applying ultrasonic waves or thermal energy.

Described herein is the use of the optic nerve sheath (ONS) response to alterations in cerebrospinal fluid (CSF) pressure for predicting the risk of developing Visual Impairment and Intracranial Pressure (VIIP) syndrome in a subject.