The present invention relates to a method for displaying an easy-to-understand medical image, comprising the steps of: a. obtaining a medical image, b. identifying at least one feature on the image of step (a), c. generating at least one mask highlighting the at least one feature, d. displaying at least one easy-to-understand medical image including at least one mask on which the at least one feature identified in step (b) is highlighted.

A multimodal fiducial marker for registration of multimodal data, including a first portion comprising magnetic material visible in magnetic particle imaging (MPI) data obtained by a magnetic particle imaging method and a second portion comprising a second material visible in image data obtained by another imaging method, which image data is registrable with the MPI data and a corresponding marker arrangement.

In accordance with disclosed embodiments, very high magnetic gradients and magnetic slew are applied to magnetizable particle imaging in order to realize high spatial resolution.

A variety of wearable magnetic assemblies are provided that are configured to produce magnetic fields having high field magnitudes and/or high field gradients. These wearable magnetic assemblies are configured to exert forces on magnetic particles disposed in a portion of subsurface vasculature (e.g., a portion of the ulnar artery near the wrist) proximate to the magnetic assemblies. These magnetic assemblies include a plurality of dipolar permanent magnets. The forces can act to attract, slow, speed, separate, or otherwise influence the magnetic particles in various applications. In some embodiments, the magnetic particles are configured to bind to an analyte of interest. The collection, separation, and/or concentration of the magnetic particles can enable detection of one or more properties of the analyte, modification of the analyte, and/or extraction of the analyte bound to the magnetic particles.

The present disclosure provides devices, systems and methods for hyperthermia cancer treatment by supplying ferromagnetic nanoparticles to a target area having or suspected of having cancer cells, the ferromagnetic nanoparticles are configured to attach to the cancer cells and heat by absorbing magnetic energy, and radiating the target area with microwaves such that the target area is within a nearfield range of the radiated microwave, and the microwave radiation nearfield is magnetically biased such that the ratio of magnetic energy to electric energy is greater than 1.

Method for the spatially resolved determination of physical, chemical and/or biological properties or state variables and/or the change therein in an examination area of an examination object by determining the change in the spatial distribution and/or the mobility, particularly the mobility in rotation, of magnetic particles in this examination area or in parts thereof as a function of the effect of physical, chemical and/or biological influencing variables on at least a part-area and/or in the physical, chemical and/or biological conditions in at least a part-area of the examination area, by means of the following steps: a) introducing covered and/or coated magnetic particles with at least one solid, viscous and/or liquid shell or coating into at least part of the examination area and/or introducing magnetic particles into at least part of the examination area and/or covering and/or coating at least some of these particles in the examination area, b) generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in the examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, 15 c) changing the, in particular relative, spatial position of the two part-areas in the examination area or changing the magnetic field strength in the first part-area so that the magnetization of the particles is locally changed, d) detecting signals that depend on the magnetization in the examination area that is influenced by this change, and e) evaluating the signals so as to obtain information about the change in the spatial distribution and/or mobility of the magnetic particles in the examination area. The invention also relates to functionalized magnetic particle compositions and magnetic particle compositions suitable for use in the above method. The invention further also relates to an apparatus for the measurement of state variables in the examination area.

A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.

The present invention relates to a coil arrangement, in particular for use in a magnetic particle imaging apparatus (100), comprising a coil split into at least two coil segments, wherein the winding direction is inverted between at least one coil segment to another coil segment, and a capacitor coupled between at least two adjacent coil segments. Further, the present invention relates to such a magnetic particle imaging apparatus, in particular an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), which apparatus comprises selection means and drive means (120) wherein at least one drive field coil and/or at least one selection field coil representing a selection field element is implemented by a coil arrangement as proposed according to the present invention.

Disclosed herein is a nano-magnetic-particle-imaging apparatus, including a measurement head including excitation and detection coils and accommodating a sample bed for a sample including nano magnetic particles; a gradient magnetic field generation unit for generating a magnetic field having a strength equal to or greater than that of the saturation magnetic field of the nano magnetic particles in a spacing area between identical magnetic poles facing each other and forming a field-free region in a portion thereof; a first driving unit for linearly moving the sample bed; a second driving unit for rotating the gradient magnetic field generation unit in a plane; a third driving unit for linearly reciprocating the gradient magnetic field generation unit; and a control unit for applying a signal to the excitation coil, controlling the driving units, and imaging 3D distribution of the nano magnetic particles based on a detection signal output from the detection coil.

A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.