Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

A measurement unit for measuring a bio-impedance of a body, the measurement unit comprising a current generator circuit, a readout circuit, and a baseline cancellation current circuit, wherein the current generator circuit is configured to amplify a reference current to form a measurement current to be driven through a body to generate a measurement voltage representing the bio-impedance; wherein the readout circuit comprises a Instrumentation amplifier (IA) which has a transconductance stage and a transimpedance stage, wherein the IA is configured to: produce a first current in the transconductance stage, the first current being proportional to the measurement voltage, receive a second current from the baseline cancellation current circuit, produce an output voltage in the transimpedance stage, the output voltage being proportional to a difference between the first current and the second current and representative of the measured bio-impedance; wherein the baseline cancellation current circuit is configured to amplify the reference current by a factor to form the second current and deliver it to the IA, wherein the factor is such that that the absolute value of the difference between the first and the second current is below a threshold such that a baseline of the first current is cancelled by the second current.

A measurement unit for measuring a bio-impedance of a body, the measurement unit comprising a current generator circuit, a readout circuit, and a baseline cancellation current circuit, wherein the current generator circuit is configured to amplify a reference current to form a measurement current to be driven through a body to generate a measurement voltage representing the bio-impedance; wherein the readout circuit comprises a Instrumentation amplifier (IA) which has a transconductance stage and a transimpedance stage, wherein the IA is configured to: produce a first current in the transconductance stage, the first current being proportional to the measurement voltage, receive a second current from the baseline cancellation current circuit, produce an output voltage in the transimpedance stage, the output voltage being proportional to a difference between the first current and the second current and representative of the measured bio-impedance; wherein the baseline cancellation current circuit is configured to amplify the reference current by a factor to form the second current and deliver it to the IA, wherein the factor is such that that the absolute value of the difference between the first and the second current is below a threshold such that a baseline of the first current is cancelled by the second current.

Systems and methods relating to bio-impedance analysis. The system eliminates the need for hardware phase measurements by using the K-K transform to extract the phase from the magnitude detected. The system has a magnitude detection sub-system that includes a signal generation block, a DC cancellation block, and an amplitude control block. An A/D converter converts the detected magnitude into a digital signal and signal processing is performed to extract the phase of the signal from the magnitude detected.

Systems and methods relating to bio-impedance analysis. The system eliminates the need for hardware phase measurements by using the K-K transform to extract the phase from the magnitude detected. The system has a magnitude detection sub-system that includes a signal generation block, a DC cancellation block, and an amplitude control block. An A/D converter converts the detected magnitude into a digital signal and signal processing is performed to extract the phase of the signal from the magnitude detected.

Systems and methods are described for the monitoring of patient motion via the detection of changes in capacitance, as measured using a capacitance position sensing electrode array. The changes in capacitance may be processed to determine a corresponding positional offset, for example, using a calibration data set relating capacitance to offset for each electrode of the array. The detected positional offset may be employed to provide feedback to a surgeon or operator of a medical device, or directly to the medical device for the control thereof. A medical procedure may be interrupted when the positional offset is detected to exceed a threshold. Alternatively, the detected positional offset may be employed to manually or automatically reconfigure a medical device to compensate for the detected change in position. Various configurations of capacitive position sensing devices are disclosed, including embodiment in incorporating capacitive sensing electrodes with a mask or other support structure.

Systems and methods are described for the monitoring of patient motion via the detection of changes in capacitance, as measured using a capacitance position sensing electrode array. The changes in capacitance may be processed to determine a corresponding positional offset, for example, using a calibration data set relating capacitance to offset for each electrode of the array. The detected positional offset may be employed to provide feedback to a surgeon or operator of a medical device, or directly to the medical device for the control thereof. A medical procedure may be interrupted when the positional offset is detected to exceed a threshold. Alternatively, the detected positional offset may be employed to manually or automatically reconfigure a medical device to compensate for the detected change in position. Various configurations of capacitive position sensing devices are disclosed, including embodiment in incorporating capacitive sensing electrodes with a mask or other support structure.

The present disclosure provides a method, performed in an accessory device, for communicating a leakage state of an ostomy appliance, wherein the accessory device comprises an interface configured to communicate with one or more devices of an ostomy system, the one or more devices comprising a monitor device, and/or the ostomy appliance configured to be placed on a skin surface of a user. The method comprises obtaining monitor data from the one or more devices, the monitor data being indicative of presence of fluid at a proximal side of a first adhesive layer of the ostomy appliance towards the skin surface; determining a leakage state at the proximal side of the first adhesive layer of the ostomy appliance based on the monitor data, and communicating the leakage state of the ostomy appliance via the interface.

The present disclosure provides a method, performed in an accessory device, for communicating a leakage state of an ostomy appliance, wherein the accessory device comprises an interface configured to communicate with one or more devices of an ostomy system, the one or more devices comprising a monitor device, and/or the ostomy appliance configured to be placed on a skin surface of a user. The method comprises obtaining monitor data from the one or more devices, the monitor data being indicative of presence of fluid at a proximal side of a first adhesive layer of the ostomy appliance towards the skin surface; determining a leakage state at the proximal side of the first adhesive layer of the ostomy appliance based on the monitor data, and communicating the leakage state of the ostomy appliance via the interface.

An apparatus is provided for receiving an indication of a temperature measurement made at a site on a body, the first measurement being of a first type; receiving an indication of an electrical measurement of one or more electrical characteristics made at the site where the temperature measurement was made; determining, based at least in part on the measurement of the one or more electrical characteristics, the site on the body where the temperature measurement was made; associating the measured temperature with the determined site. A method and a computer program product are also provided.