Mandibular repositioning devices providing downward movement as well as forward movement of the mandible have a maxillary tooth covering having a driver flange protruding laterally outward on one or both sides thereof and have a mandibular tooth covering having a protrusive flange extending cranially therefrom positioned to have a posterior side engaged with the anterior side of each driver flange. The anterior side of each driver flange has a convex curvature. The posterior side of each protrusive flange has a concave-to-convex curvature positioned to move the convex portion thereof along the convex curvature of the driver flange when the mouth opens, which also moves the mandible forward. A plateau of a preselected height, which prevents disconnect between each protrusive flange and its respective driver flange relative to a fully open mouth measurement, is present between the base of the protrusive flange and the tooth covering.

Mandibular repositioning devices providing downward movement as well as forward movement of the mandible have a maxillary tooth covering having a driver flange protruding laterally outward on one or both sides thereof and have a mandibular tooth covering having a protrusive flange extending cranially therefrom positioned to have a posterior side engaged with the anterior side of each driver flange. The anterior side of each driver flange has a convex curvature. The posterior side of each protrusive flange has a concave-to-convex curvature positioned to move the convex portion thereof along the convex curvature of the driver flange when the mouth opens, which also moves the mandible forward. A plateau of a preselected height, which prevents disconnect between each protrusive flange and its respective driver flange relative to a fully open mouth measurement, is present between the base of the protrusive flange and the tooth covering.

The invention relates to a spirometer (1) comprising a MEMS-based thermal fluid flow sensor (13, 13.1, 13.2) for generating a signal in response to a fluid flow generated during inhalation or exhalation; and a microcontroller (14) for calculating the fluid flow from the signal generated by the flow sensor (13, 13.1, 13.2). The spirometer (1) may be connected to other devices, such as a smartphone or a personal computer or any other computing unit which is adapted to collect, store, analyse, exchange and/or display data. The invention further describes the use of the spirometer (1) in measuring a user's lung performance and/or monitoring it over time. Furthermore, the spirometer (1) may be provided in a system together with an air quality measurement device for determining the air quality at a location of interest; and a computing unit for collecting, analysing and correlating the user's lung performance data obtained from the spirometer (1) with the air quality data, and optionally geolocalisation data of said location.

The invention relates to a spirometer (1) comprising a MEMS-based thermal fluid flow sensor (13, 13.1, 13.2) for generating a signal in response to a fluid flow generated during inhalation or exhalation; and a microcontroller (14) for calculating the fluid flow from the signal generated by the flow sensor (13, 13.1, 13.2). The spirometer (1) may be connected to other devices, such as a smartphone or a personal computer or any other computing unit which is adapted to collect, store, analyse, exchange and/or display data. The invention further describes the use of the spirometer (1) in measuring a user's lung performance and/or monitoring it over time. Furthermore, the spirometer (1) may be provided in a system together with an air quality measurement device for determining the air quality at a location of interest; and a computing unit for collecting, analysing and correlating the user's lung performance data obtained from the spirometer (1) with the air quality data, and optionally geolocalisation data of said location.

An apparatus for measuring a performance metric of a heart includes a housing, a tactile sensor, a finger clamp, a linear actuator, and a controller. The tactile sensor measures blood pressure pulsatility in a digital artery of a finger via applanation tonometry and outputs pulsatility signals indicative of the blood pressure pulsatility. The finger clamp extends from the housing to clamp the finger against the tactile sensor with the digital artery aligned over the tactile sensor. The linear actuator drives the finger clamp with a clamping force directed along a linear path. The controller is coupled to the tactile sensor and the linear actuator to control the clamping force and to generate pulsatility data, based upon the pulsatility signals, from which the performance metric of the heart may be determined.

Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data.

Methods of and devices for detecting a measurable characteristic of the gas sample. The methods and devices are able to detect a value of or a change of measurable characteristic (e.g., such as chemical concentrations), a change of chemical compositions and/or biological responses of a living organism that are induced by a stressor. The biological responses are able to include cellular stress, damage, and immune responses. The stressor is able to include an exposure to ionizing radiation. The effects of the stressors are able to be monitored in terms of changes in the chemical concentrations and chemical compositions in an exhaled breath. The chemicals are able to function as bio-markers. The chemicals that are to be monitored are able to include nitric oxide, carbon monoxide, carbon dioxide, ethane, and other molecules related to specific disease resulting from the stressor.

Methods of and devices for detecting a measurable characteristic of the gas sample. The methods and devices are able to detect a value of or a change of measurable characteristic (e.g., such as chemical concentrations), a change of chemical compositions and/or biological responses of a living organism that are induced by a stressor. The biological responses are able to include cellular stress, damage, and immune responses. The stressor is able to include an exposure to ionizing radiation. The effects of the stressors are able to be monitored in terms of changes in the chemical concentrations and chemical compositions in an exhaled breath. The chemicals are able to function as bio-markers. The chemicals that are to be monitored are able to include nitric oxide, carbon monoxide, carbon dioxide, ethane, and other molecules related to specific disease resulting from the stressor.

An apparatus for collecting aerosolized respirable particles of an inhalable medicinal formulation, having a dose collection section having an air-permeable filter extending across the pathway of the aerosolized respirable particles to retain particulate material on the filter. The dose collection section having an upper filter support member and a lower filter support member, the filter being circumferentially retained between the upper and lower support members to form a filter unit; a lower body receiving the filter unit, the lower body having recesses; and a quick-release system having hooks, movable between an open position and a closed position The hooks, in the open position, can enter the recesses around the filter unit, and in the closed position, can grab the filter unit, allowing removal of the filter unit without any human contact.

An apparatus for collecting aerosolized respirable particles of an inhalable medicinal formulation, having a dose collection section having an air-permeable filter extending across the pathway of the aerosolized respirable particles to retain particulate material on the filter. The dose collection section having an upper filter support member and a lower filter support member, the filter being circumferentially retained between the upper and lower support members to form a filter unit; a lower body receiving the filter unit, the lower body having recesses; and a quick-release system having hooks, movable between an open position and a closed position The hooks, in the open position, can enter the recesses around the filter unit, and in the closed position, can grab the filter unit, allowing removal of the filter unit without any human contact.