Disclosed is a method for fabricating a wearable hydrogel glucose sensor, belonging to the technical field of biomedical sensing, including using polyacrylamide hydrogel as a basic material, preparing a hydrogel film by adding with phenylboronic acid group capable of recognizing glucose molecules, and carrying out grating writing on the hydrogel film in a femtosecond laser direct writing mode to obtain the wearable hydrogel glucose sensor. The hydrogel film combines with glucose and expands linearly, which makes the grating period and effective refractive index change. The quantitative measurement of glucose is realized by detecting the spatial position of diffraction band and the change of diffraction power intensity.

The invention provides a system for characterizing a patient including a substrate, a first electrode, a second electrode, and an electrical system. The electrical system is connected to the substrate and worn entirely on the patient's body. The electrical system in electrical contact with both the first and second electrodes and configured to inject an alternating electrical current through the first electrode and into the region of tissue. The electrical system is configured to measure a first electrical signal from the region of tissue through the second electrode. The electrical system is configured to measure a second electrical signal from the region of tissue. The first electrical signal or a signal determined therefrom indicates a resistance of the region of tissue and the second electrical signal or a signal determined therefrom indicates a reactance of the region of tissue.

An apparatus and method for testing a patient for distinguishing symptoms of a heart attack and GERD. A saliva specimen holder is configured to collect a saliva sample. A blood specimen holder with a well configured to collect a blood sample, a D-dimer testing zone, and a membrane in fluid communication with the well and the D-dimer testing zone. The membrane is configured to fluidly communicate a blood sample to the D-dimer testing zone. A composition on the membrane in the D-dimer testing zone is configured, when mixed with blood containing a D-dimer protein, to provide an indicator. A processor is programmed to analyze the collected blood sample to determine whether a D-dimer protein is detected in the blood sample and to analyze the saliva sample and to send information to the display indicating whether or not pepsin was detected.

The present invention relates to body fluid monitoring. It is proposed to incorporate a reagent-free calibration method into a patch or wearable. The method comprises capturing molecules of interest, i.e. calibration molecules inside the bioliquid of the patient, and release them when needed for calibration. This eliminates the need for onboard reagent storage. Because the calibration is done in the same bioliquid, any matrix effects are corrected for.

The hemoglobin measuring system includes: a transvaginal probe, the transvaginal probe having a light irradiation part that is capable of emitting light to an ovarian cyst in living tissue, wherein the light contains components of a plurality of specific wavelengths from a wavelength region ranging from visible light to near-infrared light, the components including at least components of a wavelength in a visible light region, and a light receiving part that is capable of receiving reflected light or transmitted light, wherein the reflected light or the transmitted light is light emitted from light irradiation part and reflected by or transmitted through the living tissue; and a concentration calculation part that calculates hemoglobin concentration in a cystic fluid retained in the ovarian cyst based on an optical spectrum of the reflected light or transmitted light from the ovarian cyst received by the light receiving part.

The current disclosure relates to methods and devices for measuring concentrations of analytes in the gastrointestinal tract of a subject by orally administering a smart pill to the subject, the smart pill comprising two or more sensors, a reference electrode, a power source, a communication interface and electronic circuits, each sensor being able to measure an analyte in the gastrointestinal tract of said subject, wherein the two or more sensors measure different analytes, measuring a concentration of two or more analytes using the two or more sensors, wherein one of the sensors is a pH sensor for measuring hydrogen ions, and wherein the pH sensor is able to locate the smart pill in the gastrointestinal tract by correlating the measured hydrogen ion concentration to a location in the gastrointestinal tract, and transmitting, using the communication interface, the measured concentrations from the two or more sensors to a base device located outside of the body of the subject.

The present invention relates to a method for determining the presence of a circulating tumor marker in the human body, comprising detecting the tumor marker in the vagina, wherein the tumor marker originates from a part of the body that is not the vagina. In a preferred embodiment, the tumor marker is detected by means of an aptamer. Even more preferably, the aptamer is present in a vaginal ring device. The vaginal ring device suitably comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The method can for example be used in the continuous monitoring of circulating tumor markers in oncologic patients or in the pretreatment and posttreatment follow-up of oncologic patients. The invention further relates to a vaginal diagnostic ring device for performing the method.

A teething apparatus includes a water-resistant housing containing a controller and a power source and communication means and a plurality of sensors in communication with the surface of the housing arranged and configured to detect at least pH and at least one volatile organic compound. Each of the plurality of sensors is in data communication with the controller and the controller is capable of communication with an external device via communication means. The apparatus may be a component of a larger system and may be used in a method including the steps of providing a teething apparatus to an oral cavity of an infant, establishing a data connection between the teething apparatus and a remote device, and relaying information from the teething apparatus to the remote device, the information comprising the qualitative measurement of one or more volatile organic compounds and the quantitative value of pH in the oral cavity.

An apparatus for testing for streptococcal pharyngitis includes a tube having an open first end and a second end, and an opening on a side thereof, a dipstick inserted into the tube through the side opening, and an insert with a hole that can receive the dipstick and sized to nest the dipstick into the side opening of the tube. A swab at the end of the dipstick inside the tube receives microbes in a breath exhaled by a patient holding the first end of the tube to the patient's mouth. After being exhaled upon by the patient, the dipstick is removed for testing for the presence of microbes that cause streptococcal pharyngitis.

The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.