The precision of a lateral flow assay for determining the concentration of an analyte in the plasma fraction of a sample of whole blood can be significantly improved by applying an integrated step for determining the hematocrit of the optionally diluted sample, and taking both hematocrit and dilution factor into account when calculating the concentration of the analyte. This is made possible inter alia by using a predetermined wavelength when taking an image of the sample after application to a substrate in the lateral flow assay device, and wherein said wavelength is selected based on the dilution factor used. This hematocrit measurement is advantageously integrated in lateral flow assay methods and devices for the measurement of an analyte in plasma and contributes significantly to an improved precision of such assays.

Systems and methods are provided for cytometric measurement of blood cells traversing microvasculature single-file in the eye of a subject. A miniature imaging device, having cellular resolution, records image data that can be rendered into a microcirculation time sequence and analyzed to provide useful biological information.

An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

A wearable member may include a plurality of energy transmitters that are arranged on a surface of the wearable member, each of the energy transmitters being configured to project energy into tissue of a user. A wearable member may include a plurality of energy receivers each of which is configured to generate a signal based on a received portion of the energy that is projected by one or more of the energy transmitters and reflected by the tissue of the user, wherein at least one of the energy transmitters and the energy receivers are multi-dimensionally arranged on the wearable member such that energy reflected by the tissue of the user at locations that are multi-dimensionally different is incident on the plurality of energy receivers. The processor may be configured to calculate a biological metric based on signals generated by at least part of the plurality of energy receivers.

A device is provided for the optical measurement of a living body. For the purpose of separating a signal coming from the change in hemodynamics in a deep part from a signal coming from the change in hemodynamics in skin, light irradiation sites and light detection sites are positioned so that the measurement is achieved employing at least two SD distances. At two SD distances, the change in a logarithmic value of the detected light at every time point is determined employing a logarithmic value of the amount of detected light under specific conditions or at a specific time point as a starting point. A gradient value for a differential SD distance, which is a difference between the amount of change obtained by the measurement at a longer SD distance and the change obtained by measurement at a shorter SD distance, is used as a measurement amount.

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

The present disclosure is related to a method and system for providing personalised haemodialysis for subject. The method includes obtaining concentration of electrolytes and of metabolic content in blood sample flowing into and out of dialyser through first blood bypass tube and second blood bypass tube, respectively. The first and the second blood bypass tube are arranged in first sensor and second sensor. Similarly, concentration of electrolytes and metabolic content in dialysate fluid flowing into and out of dialyser through first and second dialysate tube, respectively. The first dialysate tube and second dialysate tube are arranged to pass through third sensor and fourth sensor. Further, variations are identified in concentration obtained for electrolytes and metabolic content in blood sample with respect to concentration obtained for electrolytes and metabolic content in dialysate fluid, respectively. Thereafter, removal of electrolytes and metabolic content is performed from blood sample.

The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for performing the methods of the invention.

Systems and methods for determining if a wearable photoplethysmography device is correctly positioned in operating to medical signs of a user by using a classifier to determine if a signal is valid or invalid. In some embodiments, in using the classifier to determine in a signal is valid or invalid, a lean method of linear computational complexity and minimal memory complexity is provided for determining at the wearable photoplethysmography device if it is correctly positioned. In some embodiments, in using the classifier minimal computational complexity is used in determining at the wearable photoplethysmography device if it is correctly positioned.

Systems and sensor clip assemblies for optically monitoring blood flowing through a blood chamber are provided. A sensor clip assembly includes emitters and photodetectors positioned on opposing arms, a signal conditioning circuit for conditioning raw analog signals generated by the photodetectors while the sensor clip assembly is fastened to a blood chamber, and an analog-to-digital converter for converting the conditioned analog signals to raw digital data. The sensor clip assembly may output the raw digital data to an external device and receive synchronized control signals from the external device, or the sensor clip assembly may include a microcontroller for performing calculations on the raw digital data and providing synchronized control signals internally. Parameters of blood flowing through the blood chamber such as hematocrit, oxygen saturation, and change in blood volume may be calculated from the raw digital data derived from the raw analog signals generated by the photodetectors.