A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.

An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

The present disclosure provides a physiological monitoring system that includes at least one physiological sensor indicative of a physiological condition of a patient, the at least one sensor worn by a patient. Sensors can include one or more optical sensors configured to measure a physiological parameter, such as total hemoglobin, SpO.sub.2, methemoglobin, carboxyhemoglobin, and the like. A monitoring system can receive measured information from the sensor and determine if the physiological condition of the user indicates an urgent medical need. When the physiological condition of the user indicates an urgent medical need, the electronic device can generate an alert.

There is provided a system (100) for assessing delirium in a subject. The system includes a neural activity assessment module (102) for assessing neural activity data associated with the subject. The system also includes a delirium cause assessment module (104) for assessing data relating to at least one factor of a plurality of factors which contribute to the cause of delirium. The system also includes an intervention determination module (106) for determining, based on the assessment performed by the delirium cause assessment module, at least one intervention for reducing the contribution made by the at least one factor. A computer-implemented method and an apparatus are also disclosed.

A sensor assembly for analysis of physical parameters and chemical constituents of small volume samples of bodily fluids with at least two analyte sensors. The sensor assembly including a separation panel with an upper surface and a lower surface and upper and lower fluid channels disposed within the upper and lower surfaces respectively. The fluid channels extending substantially between the first and second ends and when in an operating mode bodily fluid is in fluid communication with both the upper and lower fluid channels. The sensor assembly including a potentiometric chip positioned atop and an amperometric chip positioned beneath the separation panel with at least one analyte sensor positioned above and beneath each of the fluid channels and when the sensor assembly is in an operating mode the fluid is in fluid communication with the analyte sensors. A bonding media is disposed beneath the amperometric chip.

A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.

Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

A sensor system for diffuse reflectance tissue monitoring, the sensor system comprising: one or more integrated photonic silicon or silicon nitride broadband transceiver circuits for multi-wavelength diffuse reflectance tissue monitoring, wherein the one or more transceiver circuits includes a transmitter photonic integrated circuit (PIC), the transmitter PIC comprising an optical phased array (OP A) the OP A comprising a steering mechanism to steer transmitted light across the tissue.

An example device includes memory configured to store a first impedance and a second impedance each associated with a heart of a patient, and processing circuitry communicatively coupled to the memory. The processing circuitry is configured to determine at least one of a measure of hematocrit, an indication of fluid overload, or an indication of true anemia based at least in part on the first impedance and the second impedance. The processing circuitry is configured to output an indication of the measure of hematocrit, the indication of fluid overload, or the indication true anemia.