Collection devices, systems, and methods include those for collecting volatile organic compounds (VOCs) and/or other chemical substances from a target area of a subject’s anatomy (e.g., a subject’s skin, a wound on a subject, etc.). In some cases, the collector may have a collection component including an adsorbent material. The collector may be used with a pump. The pump may be configured to draw a fluid flow containing one or more chemical substances from a target area on a subject’s anatomy through the collection component. The collection component may be configured to collect at least some of the chemical substances from the fluid flow as the flow passes through the collection component.

Present invention provide a system and a method for recording, evaluating, screening and monitoring life style associated Non-communicable diseases related data of a subject via an Integrated Medical Device (IMD) in real time, and sharing the same on a server, either local or cloud based, for fast, active sharing of data by remote users anytime anywhere.

Methods, apparatus, systems, and methods are described that relate to microneedle-assisted aptamer-based electrochemical sensing for label-free, continuous real-time monitoring of biomarkers in a biofluid. One example device for electrochemical monitoring of one or more analytes in a biofluid includes a substrate and at least two microneedles coupled to the substrate. Each microneedle in the at least two microneedles includes a protruded needle structure and an electrode probe structure. The electrode probe structure of a first microneedle in the at least two microneedles includes an aptamer sequence which is specific for a first analyte and the electrode probe structure of the first microneedle is operable as a working electrode for detection of the first analyte using a first electrochemical detection technique.

A system for generating hyperspectral imaging data for measuring biochemical compositions is disclosed which includes a spectral imaging device adapted to acquire one or more hyperspectral linescan images, an optical imaging device with a red-green-blue (RGB) sensor adapted to acquire an RGB dataset, a processor adapted to co-locate a plurality of pixels in the RGB dataset vs. a corresponding plurality of pixels of the one or more hyperspectral linescan datasets, establish a transformation matrix utilizing the plurality of co-located pixels, apply the transformation matrix to the RGB dataset to thereby generate the hyperspectral dataset, and analyze the generated hyperspectral image dataset to determine the biochemical compositions.

Aspects of the present disclosure provide a power activation module for powering one or more wearable electronic components. The power activation module includes a switch configured to provide a path for current flow between a battery associated with the power activation module, the one or more wearable electronic components, and a ground terminal. The power activation module also includes a sensor configured to detect whether a signal is applied to the sensor and, based on the detection, output a first digital output signal for controlling, at least in part, the switch to control the current flow from the battery to the one or more wearable electronic components. The power activation module also includes a lock pin configured to receive a lock signal, wherein when the lock signal is received, the switch is locked to allow current flow from the battery to the one or more wearable electronic components.

A medical capsule with a sensor device comprising a light emitting element and a light detecting element with the sensor device being adapted to detect the presence or non-presence of blood and/or Biliverdin based on the light absorption properties of blood and Biliverdin. The capsule is provided with a casing forming a gap at its outer surface. The light emitting element alternatively emits violet light of a wavelength of about 380-450 nm, green light of a wavelength of about 530-580 nm, and red light of a wavelength of about 620-750 nm, whereas the light detecting element generates a separate sensor signal associated with measured light intensities I.sub.violet, I.sub.green, and I.sub.red of at least each of the wavelength ranges of the light from the light emitting element. By evaluating a quotient I.sub.red/I.sub.green, false-positive detection of blood can be avoided. The present disclosure also relates to a calibration method for said medical capsule.

Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).

Transdermal microneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate, a microneedle unit, a signal processing unit and a power supply unit. The microneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheets provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.

Systems and methods for health and body simulations in order to predict numerous physiological parameters in a subject or a population of subjects based on the input of limited physiological data.

An apparatus for generating a metabolism model may include a processor configured to obtain a predetermined number of bio-information profiles from a bio-sensor, extract a representative bio-information profile from the obtained predetermined number of bio-information profiles, and generate the metabolism model for correcting an error of the bio-sensor by using the extracted representative bio-information profile.