A virtual or augmented reality system is disclosed which is capable of both (i) evaluating prospective implantable neurostimulator patient candidates, and (ii) determining optimal stimulation settings for already-implanted neurostimulation patients. Physiological sensors are included with the system to provide objective measurements relevant to a patient's symptoms, such as pain in a Spinal Cord Stimulation (SCS) system. Such objective measurements are determined during the presentation of various virtual or augmented environments, and can be useful to determining which patients are suitable candidates to consider for implantation. Stimulation settings for already-implanted patients may be adjusted while presenting a virtual or augmented environment to the patient, with objective measurements being determined for each stimulation setting. Such objective measurements can then be used to determine optimal stimulation settings for the patient.

A reusable and electrochemically active device 100 is provided comprising, detachable electrode arrangement including working electrodes 101a, 101b, 101c, 101d and a counter electrode 102 that are functionalised with selected electrochemically active receptor(s) that can interact with at least a target bioanalyte. Fluid transportation channels 108a, 108b, 108c, 108d are formed, to receive biological samples with the at least target bioanalyte and for further transportation to the selected electrode arrangement, preferably in a sequential manner, for measuring the concentrations of the target bioanalytes. Used working electrodes 101a, 101b, 101c, 101d and a partial portion of the counter electrode 102 are detachable from the device 100. Insulating members 113a, 113b, 113c, 113d, 113e, 113f, 113g are disposed on the electrode arrangement such that the integrity of the electrical connectivity of the remaining electrode arrangement is retained even after the detachment of the used working electrodes 101a, 101b, 101c, 101d and a portion of the counter electrode 102. The present invention also provides a point-of-care biosensor 300 and a method to electrochemically measure the concentrations of multiple target bioanalytes and a single bioanalyte repeatedly.

A reusable and electrochemically active device 100 is provided comprising, detachable electrode arrangement including working electrodes 101a, 101b, 101c, 101d and a counter electrode 102 that are functionalised with selected electrochemically active receptor(s) that can interact with at least a target bioanalyte. Fluid transportation channels 108a, 108b, 108c, 108d are formed, to receive biological samples with the at least target bioanalyte and for further transportation to the selected electrode arrangement, preferably in a sequential manner, for measuring the concentrations of the target bioanalytes. Used working electrodes 101a, 101b, 101c, 101d and a partial portion of the counter electrode 102 are detachable from the device 100. Insulating members 113a, 113b, 113c, 113d, 113e, 113f, 113g are disposed on the electrode arrangement such that the integrity of the electrical connectivity of the remaining electrode arrangement is retained even after the detachment of the used working electrodes 101a, 101b, 101c, 101d and a portion of the counter electrode 102. The present invention also provides a point-of-care biosensor 300 and a method to electrochemically measure the concentrations of multiple target bioanalytes and a single bioanalyte repeatedly.

Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

The present invention relates to a biosensor for determining an analyte comprising a substrate, a working electrode comprising an electrically conductive pad in conductive contact with a mediator layer, and an enzyme layer in diffusion-enabling contact with said mediator layer, wherein said mediator layer is an electrodeposited mediator layer, and wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent. The present invention further relates to a method for manufacturing a biosensor, comprising providing a substrate having at least one conductive pad, electrodepositing a mediator layer onto at least part of said conductive pad, wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent, and depositing an enzyme layer onto at least part of said mediator layer. Moreover, the present invention relates to uses and methods related to the biosensor of the present invention.

The present invention relates to a biosensor for determining an analyte comprising a substrate, a working electrode comprising an electrically conductive pad in conductive contact with a mediator layer, and an enzyme layer in diffusion-enabling contact with said mediator layer, wherein said mediator layer is an electrodeposited mediator layer, and wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent. The present invention further relates to a method for manufacturing a biosensor, comprising providing a substrate having at least one conductive pad, electrodepositing a mediator layer onto at least part of said conductive pad, wherein said mediator layer comprises, in an embodiment consists of, an electrocatalytic agent, and depositing an enzyme layer onto at least part of said mediator layer. Moreover, the present invention relates to uses and methods related to the biosensor of the present invention.

A health monitoring urinalysis system that monitors several health indicators from human urine is provided. The system includes a temperature sensor and several electrochemical sensors that are installed in a urine collection basin, such as, a toilet or a urinal and may automatically collect urine information after each use. The system collects data during the routine and normal use of a urine collection basin. The system includes a control and measurement unit that may be installed outside the urine collection basin. The control and measurement unit receives sensor measurements and transmits the measurements to one or more remote electronic devices. The remote electronic devices and/or the processor of the control and measurement unit perform data analysis, provide diagnostic, and generate health alerts. The system performs recurrent health monitoring after the urine collection basin is used and may detect abnormal conditions at early stages, in addition to a routine urine test.

Disclosed embodiments include methods and systems including a receiver unit of a glucose monitoring system. The receiver is configured for communicating with a remote transmitter unit coupled with a glucose sensor. The glucose sensor generates data signals associated with a glucose level. The receiver unit includes a processor, a display, and a memory for storing instructions which, when executed by the processor: access a transmitter key associated with the remote transmitter unit; transmit a command to the remote transmitter unit after verifying the transmitter key; receive communication packets from the remote transmitter unit including a first data segment with data signals indicative of the glucose level and a second data segment with information corresponding to a remaining life of the remote transmitter unit; estimate a remaining life of the remote transmitter unit; process the data signals; and output the estimated remaining life and the processed data signals for display.

Disclosed embodiments include methods and systems including a receiver unit of a glucose monitoring system. The receiver is configured for communicating with a remote transmitter unit coupled with a glucose sensor. The glucose sensor generates data signals associated with a glucose level. The receiver unit includes a processor, a display, and a memory for storing instructions which, when executed by the processor: access a transmitter key associated with the remote transmitter unit; transmit a command to the remote transmitter unit after verifying the transmitter key; receive communication packets from the remote transmitter unit including a first data segment with data signals indicative of the glucose level and a second data segment with information corresponding to a remaining life of the remote transmitter unit; estimate a remaining life of the remote transmitter unit; process the data signals; and output the estimated remaining life and the processed data signals for display.

The present invention relates to a liquid information sensor comprises at least more than one electrode set including a first electrode, and a second electrode which is disposed spaced apart from the first electrode and to which an alternating current signal is applied between the first electrode and the second electrode; and a ferroelectric layer including a first side in contact with the first electrode and the second electrode and a second side facing the first side and defining a receiving area for receiving the target liquid, and generating sound waves by physical vibration when the AC signal is applied.