Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

Systems and methods for treating a subject with a psychiatric disorder are provided in which a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. Each expression image is independently associated with an expression. The successive display of images is construed as a tiled series of expression image subsets, each consisting of N expression images. Upon completion of the display of each respective subset, the user is challenged as to whether the first and the last images in the respective subset exhibit the same emotion. A score is determined for the respective subset based on whether the subject learned to respond correctly. The number of images in each subset is adjusted to a new number based on these scores. A treatment regimen is prescribed to the subject for the psychiatric disorder based at least in part on the scores.

A system and method to capture and interact with a comprehensive digital record of an individual's biographical history and produce a synthetic model of their personality. The captured biographical history is a detailed record of this individual's actions, interactions, and experiences over a period which may span decades of their lifetime. The biographical history is indexed by areas of data variability and neural network confidence variability to identify points of likely human interest. A synthetic personality model is generated as a representation of the individual's personality structure, biases, sentiments, and traits. The synthetic personality can be interacted with through a digital interface and demonstrates the interaction patterns, triggers, and habits of the original individual. The functioning and the performance of the system over an individual's lifespan are optimized through data synthesis and disposition.

Methods and apparatus for a social-oriented computer system for matching daters. Daters establish friend connections with other users, including non-daters. After identifying candidate pairings of daters, the system solicits the opinions of users including the daters, their friends, and matchmakers. The system may analyze the opinions to determine whether a match would result in the satisfaction of both daters. If so, the system matches the daters, inviting them to communicate. The system may gather feedback on the match to help calibrate future matching.

A method for processing EEG signals includes reading the EEG signals from two frontal electrodes of an electroencephalograph (301); converting the EEG signals to a frequency domain (305); determining values of a BIS/BAS response on the basis of an asymmetry between the EEG signals (208). The method includes calculating the asymmetry between the EEG signals in the frequency domain in a frequency range from 26 to 29 Hz.

Apparatus and systems are described that include physical media related to accepting at least one attribute associated with an individual from a licensed health care provider and/or presenting an output of an artificial sensory experience associated with a request to measure at least one effect of a bioactive agent on the attribute associated with individual.

The present invention relates to a software-based system and method of mindset training with gamification, implemented on stand-alone computing devices or over a network using computing devices. More specifically, the present invention relates to modifying the mindset of users of the system and method by means of mindset goal specification and corresponding mindset content curation, mindset conditioning games, social network engagement, and performance tracking.

This invention, which focuses on personality and aptitude matching by psychophysiologic response to stimuli, is referred to as Brain Matching. In general terms, this invention starts by selecting highly specialized skill sets and top performer group for each skill set. The various groups are analyzed though psychophysiologic stimuli testing by using basically the same testing consisting of large numbers stimuli tests in a consistent testing environment. Stimuli tests can range from hundreds to thousands of images each producing a brainwave response. Neural Networks, Artificial Intelligence, Deep Learning computers look at the test results, highly specialized group by other highly specialized group to reduce the groups signature/response commonality into a template. Test subjects are then tested using the same stimuli. The subject's test results are analyzed for correlation with the various specialized expert groups.

A computer-implemented method for adaptive behavioral training includes presenting a first visual training area to a user in a visual presentation. The visual presentation is displayed in a coordinate space and the first visual training area is defined by a first set of coordinates in the coordinate space. Measurement data is collected while the first visual training area is presented to the user. This measurement data comprises eye tracking measurement data indicating the user's gaze with respect to the first visual training area. Based on the measurement data, a second visual training area is selected. This second visual training area is defined by a second set of coordinates in the coordinate space that are different than the first set of coordinates. The second visual training area is then presented to the user in the visual presentation.

A method of improving self-esteem, confidence, and public speaking skills of an individual, including asking the individual a series of questions regarding a plurality of social concerns of the individual, rating a level of self-esteem, a level of confidence, and a level of public speaking skills of the individual, identifying and assessing the social concerns of the individual as related to self-esteem, confidence, and public speaking skills, using a diagram having a plurality of terms regarding an intra-personal point-of-view and an inter-personal point-of-view, asking the individual to identify the terms from the diagram that form a root cause of the social concerns of the individual, and assisting the individual to identify at least one additional area of concern based on the rating of the level of self-esteem, the level of confidence, and the level of public speaking skills of the individual.