In some examples, a medical device includes an elongated body defining an inner lumen. The medical device further includes an anchoring member and a first sensor at a proximal portion of the elongated body, and a second sensor at a distal portion of the elongated body or distal to a distal end of the elongated body. The second sensor is configured to sense a substance of interest and the elongated body comprises a material that is a substantially non-permeable to the substance of interest.

The present invention relates to a device for measuring a bodily fluid drainage amount, the device comprising: a measurement case which is formed of a rigid material and provided with a bodily fluid measurement space therein; a drainage tube which is coupled to an entrance of the measurement case in a releasable structure and transfers bodily fluids discharged from a human body to the bodily fluid measurement space of the measurement case; a plurality of fluid level sensors, which are horizontally disposed on an upper surface of the measurement case and measure and inform fluid levels of the bodily fluids collected in the bodily fluid measurement space; and a control device which receives and analyzes the fluid levels of the bodily fluids, infers a tilt of the measurement case from a difference in the fluid levels of the bodily fluids, and calculates and informs a bodily fluid drainage amount.

A renal function assessment method includes following steps. A target kidney ultrasound image data of a subject is provided. An image pre-processing step is performed, wherein an image size of the target kidney ultrasound image data is adjusted, and the target kidney ultrasound image data is normalized according to an average and a standard deviation of a visual image database to obtain an after-processed target kidney ultrasound image data. A feature extracting step is performed, wherein the after-processed target kidney ultrasound image data is trained to achieve a convergence by a first deep-learning classifier to obtain an image feature of the after-processed target kidney ultrasound image data. A determining step is performed, wherein the image feature of the after-processed target kidney ultrasound image data is analyzed by the first deep-learning classifier to obtain an assessing result of an estimated glomerular filtration rate (eGFR).

Systems and methods for assessing a patient's risk of renal dysfunction are described. A system may include sensor circuits to sense physiological signals and processors to generate signal metrics from the physiological signals. The system may generate a primary renal risk indication using a first signal metric, and a secondary renal risk indication using at least a second signal metric. The system may generate a composite renal risk indication and estimate a glomerular filtration rate or a chronic kidney disease stage using at least the primary and secondary risk indications. The composite renal risk indication, which indicative of a degree of renal dysfunction, may be presented to a clinician, or provided to a detector for detecting worsening heart failure.

Methods, systems, devices, assemblies and apparatuses for treatment of hypertension in a patient using renal denervation. The therapeutic assembly includes an energy delivery element. The energy delivery element is configured to provide renal denervation energy to a nerve within a blood vessel of a patient. The therapeutic assembly includes a controller. The controller is coupled to the energy delivery element. The controller is configured to determine that the hypertension in the patient is orthostatic. The controller is configured to apply renal denervation energy to the patient using the energy delivery element.

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

In a microrunner structure, there are provided with components for a cleaning procedure required to conduct electrochemical sensing when a biosensor is activated for sensing; and a urine signal detection device that is a SoC (System on a Chip), which has a wireless transceiving circuit for receiving a urine measurement method and channel information transmitted from an intelligent device, and in turn, outputting a stimulus signal to trigger a biosensor or a non-biosensor in a multi-channel structure to conduct urine sense processing for a sensing area, as well as transmitting detection processing for a concentration of urine substances from the electrochemical sensing to the intelligent device through the wireless transceiving circuit to assess a risk index between a heart disease or diabetes and a kidney disease.

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

Example assemblies and techniques for introducing a conductive element into a catheter are disclosed. An example assembly includes a sensing device configured to sense a parameter of interest in a fluid, the sensing device including sensor circuitry at a distal portion, a sensing element at a proximal portion, and a conductive element communicatively coupled to the sensor circuitry and the sensing element. The assembly includes an introducer defining an introducer lumen configured to receive at least a portion of the conductive element of the sensing device, the introducer being configured to be inserted into a catheter lumen of a catheter while the at least the portion of the conductive element is in the introducer lumen. The assembly further includes a rigid member mechanically coupled to the sensing device and configured to open a longitudinal surface of the introducer as the introducer is retracted relative to the sensing device.