Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

In some examples, a device includes a catheter insert elongated body defining a body lumen, the catheter insert elongated body being configured to be at least partially inserted to a catheter lumen defined by a catheter without covering a first fluid opening of the catheter and to form a fluidically tight coupling with the catheter, and one or more sensors positioned on the elongated body. At least one of the one or more sensors are configured to sense a substance of interest. The catheter insert elongated body includes a material that is a substantially non-permeable to the substance of interest.

A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

Disclosed herein is a two-piece sensor assembly that includes an attachment collar configured to attach to a body surface of a patient and comprising at least one opening, and a skin sensor configured to seat into the at least one opening in the attachment collar. The skin sensor includes at least one radiation source configured to irradiate the body surface with at least one interrogation light, and at least one detector configured to detect at least one response light incident from the direction of the body surface.

A heart monitoring system for a person includes one or more wireless nodes; and wearable appliance in communication with the one or more wireless nodes, the appliance monitoring vital signs.

Systems, apparatuses, and methods for diagnosing ureteropelvic junction obstruction. A set of biomarkers may be extracted from each of one or more time-activity curves associated with diuresis renography and/or functional magnetic resonance urography of one or more kidneys of a patient. One or more calculations can be performed based on the set of biomarkers to identify uretero-pelvic junction obstruction and a classification of severity or criticality thereof.

Systems and methods for assessing a patient's risk of renal dysfunction are described. A system may include sensor circuits to sense physiological signals and processors to generate signal metrics from the physiological signals. The system may generate a primary renal risk indication using a first signal metric, and a secondary renal risk indication using at least a second signal metric. The system may generate a composite renal risk indication and estimate a glomerular filtration rate or a chronic kidney disease stage using at least the primary and secondary risk indications. The composite renal risk indication, which indicative of a degree of renal dysfunction, may be presented to a clinician, or provided to a detector for detecting worsening heart failure.