The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

Systems and methods are provided herein for monitoring electrocardiogram (ECG) electrodes. Each ECG electrode is electrically connected to a patient body and a corresponding current source. A reference ECG electrode of the monitored ECG electrodes is selected. Current is injected into each electrode. Each current has a respective predetermined level. Based on the injected currents, ECG electrode voltages are generated. The injected currents are adjusted after measuring the ECG electrode voltages while the predetermined level through the reference ECG electrode is maintained. An impedance associated with each non-reference ECG electrode is determined based on the ECG electrode voltage and the injected current.

Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.

The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities.

A wrist-worn input device measuring a biopotential for use in gesture inputting, includes a band that forms at least part of a tubular structure having a first opening and a second opening at the two ends thereof in an axial direction thereof, an electrode open to an internal surface of the band, a position determination unit disposed close to the first opening and having a shape to be engaged with at least part of a periphery of the styloid process of ulna of a user, a biopotential measurement unit that measures the biopotential of the user using the electrode, and a measured potential transmitter that outputs the biopotential of the user.

A biopotential can be measured with high accuracy without the electrodes coming into direct contact with the skin and without being affected by any motion artifact. The present invention comprises a first lead which detects a biopotential containing noise components, a second lead which is electrically isolated from the first lead and detects noise components, and a differential amplifier circuit which is input with a first signal output from the first lead and a second signal output from the second lead, and which amplifies and outputs a difference between the first signal and the second signal, wherein a value of an input impedance on the second signal side of the differential amplifier circuit is set so that the noise components detected from the second lead will have a frequency that is higher than a frequency spectrum of the biopotential.

A signal detection device includes a measurer, an arithmetic operation unit, and signal period detector, and detects information such as a cardiac cycle with high accuracy by causing resonance of only a signal such as a heartbeat, the signal having strong pulse characteristics. The measurer measures a signal. The arithmetic operation unit performs nonlinear arithmetic operation processing for amplifying a pulse-like component of the signal measured by the measurer and suppressing a component other than the pulse-like component of the signal measured by the measurer. The signal period detector detects a periodic signal from an output of the arithmetic operation unit.

The present disclosure is directed to a device with enhanced human activity recognition. The device detects a human activity using one more motion sensors, and enhances the detected human activity depending on whether the device is in an indoor environment or an outdoor environment. The device utilizes one or more electrostatic charge sensors to determine whether the device is in an indoor environment or an outdoor environment.

Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities.