The present invention relates to a method of analysing cardiac data relating to a patient, comprising: providing cardiac data relating to the patient—optionally by using a means for providing physiological data (20); determining one or more properties of the data, wherein the or each property is determined over a particular context length, the context length being selected based on the or each property—optionally using an analysis module (24); comparing the or each property against a respective predetermined threshold value, thereby to indicate a probability of the patient experiencing a cardiac event—optionally using a means for providing an output (26); and providing an output based on the comparison. A system and apparatus corresponding to this method is also disclosed.

The subject of the invention is a method for calibrating a direct neural interface. The calibration is performed by considering a so-called input calibration tensor, formed on the basis of measured electrophysiological signals and so-called output calibration tensor, formed on the basis of measured output signals. The method comprises the application of a least squares multivariate regression implemented by considering a covariance tensor and a cross-covariance tensor which are established on the basis of input and output calibration tensors corresponding to a current calibration period. The method takes into account covariance and cross-covariance tensors established during an earlier calibration period prior to the current calibration period, these tensors being weighted by a forget factor.

The subject of the invention is a method for calibrating a direct neural interface. The calibration is performed by considering a so-called input calibration tensor, formed on the basis of measured electrophysiological signals and so-called output calibration tensor, formed on the basis of measured output signals. The method comprises the application of a least squares multivariate regression implemented by considering a covariance tensor and a cross-covariance tensor which are established on the basis of input and output calibration tensors corresponding to a current calibration period. The method takes into account covariance and cross-covariance tensors established during an earlier calibration period prior to the current calibration period, these tensors being weighted by a forget factor.

A contact sensor and system for incorporation within clothing and other wearable items to monitor activity at a body surface. The sensor includes a contact membrane having a body surface contacting area and one or more base layers of knitted fabric. The base layer(s) is thicker over an area congruent with the body surface contacting area of the contact membrane. As a result, the contact membrane is urged into the forming of a raised outer surface for projection against a body surface.

A contact sensor and system for incorporation within clothing and other wearable items to monitor activity at a body surface. The sensor includes a contact membrane having a body surface contacting area and one or more base layers of knitted fabric. The base layer(s) is thicker over an area congruent with the body surface contacting area of the contact membrane. As a result, the contact membrane is urged into the forming of a raised outer surface for projection against a body surface.

A device for determining the physiological condition of a person in a simple manner, which device measures the pulse rate and based on that additionally determines the heart rate variability. In addition, at least one parameter should be used for the history of one of the two above-mentioned values. The deviation of the pulse rate and the heart rate variability from a normal variable is preferably integrated and used as an additional indicator. The device preferably includes a wearable electrocardiography device.

A method includes receiving analog body-surface signal from body-surface electrode, and multiple analog unipolar signals from multiple unipolar electrodes of an invasive probe. A first unipolar electrode is assigned to serve as a common electrical ground and a common timing reference for the analog unipolar signals and the analog body-surface signal. The analog unipolar signals are digitized to produce digital unipolar signals sampled relative to a digital ground. Defined are an analog bipolar signal between the first unipolar electrode and a second unipolar electrode of the probe, and digital bipolar signal formed from the first unipolar electrode and the second unipolar electrode. Ground and timing offsets between the analog bipolar signal and the digital bipolar signal are estimated, while the first unipolar electrode is connected to the digital ground. The ground offset and the timing offset are applied in measuring a third unipolar signal, sensed by a third unipolar electrode.

A method includes receiving analog body-surface signal from body-surface electrode, and multiple analog unipolar signals from multiple unipolar electrodes of an invasive probe. A first unipolar electrode is assigned to serve as a common electrical ground and a common timing reference for the analog unipolar signals and the analog body-surface signal. The analog unipolar signals are digitized to produce digital unipolar signals sampled relative to a digital ground. Defined are an analog bipolar signal between the first unipolar electrode and a second unipolar electrode of the probe, and digital bipolar signal formed from the first unipolar electrode and the second unipolar electrode. Ground and timing offsets between the analog bipolar signal and the digital bipolar signal are estimated, while the first unipolar electrode is connected to the digital ground. The ground offset and the timing offset are applied in measuring a third unipolar signal, sensed by a third unipolar electrode.

A wearable cardiac monitoring and treatment device for improved skin interface contact and easy assembly and disassembly includes a garment including an inner surface and an outer surface, ECG sensing electrodes, and at least one stiffener forming a section of the garment in proximity to one or more of the ECG sensing electrodes. The at least one stiffener is configured to resist rotation or pulling away of the one or more of the ECG sensing electrodes from a patient's torso. The device includes therapy electrodes, at least one separate module including a therapy delivery circuit, and a controller. The device includes compartments configured to receive the therapy electrodes and at least one separate module, and retention loops configured to route external wires extending between at least the therapy electrodes and at least one separate module, where the compartments and retention loops are disposed on the outer surface of the garment.

A wearable cardiac monitoring and treatment device for improved skin interface contact and easy assembly and disassembly includes a garment including an inner surface and an outer surface, ECG sensing electrodes, and at least one stiffener forming a section of the garment in proximity to one or more of the ECG sensing electrodes. The at least one stiffener is configured to resist rotation or pulling away of the one or more of the ECG sensing electrodes from a patient's torso. The device includes therapy electrodes, at least one separate module including a therapy delivery circuit, and a controller. The device includes compartments configured to receive the therapy electrodes and at least one separate module, and retention loops configured to route external wires extending between at least the therapy electrodes and at least one separate module, where the compartments and retention loops are disposed on the outer surface of the garment.