A magnetic resonance imaging apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to specify a search start position of a matrix representing inter-regional connectivity between a plurality of regions in a brain based on a result of an analysis on an image of a subject and an attention degree set to each of the regions. The processing circuitry is configured to search the matrix using the search start position.

A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals from the signal detector, and apply a filter to the received electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subject's skin.

Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. A processing component includes a sensor mapping component configured to quantify activity associated with a proper subset of the plurality of fascicles, an evaluation component configured to determine an adjustment of the status of the controlled entity from the quantified activity of the proper subset of the plurality of fascicles, and a controller configured to provide a control signal, representing the adjustment of the status of the controlled entity, to the controlled entity.

A robotic system includes retrieval of a priori stimulus based on an input that indicates a current health state and a target health state of a user. A set of test stimuli specific for the user is determined and a stimulus device is controlled to provide the set of test stimuli to the user. A first set of responses within the body of the user and a second set of responses discernible on the body of the user are determined, and a set of stimulus parameters for the stimulus device is calibrated based on the combination of the first set of responses, the second set of responses, the current health state, the target health state, and a trained AI-based system. A new stimulus is applied to a portion of the body of the user that shifts a condition of the user from the current health state towards the target health state.

A robotic system includes retrieval of a priori stimulus based on an input that indicates a current health state and a target health state of a user. A set of test stimuli specific for the user is determined and a stimulus device is controlled to provide the set of test stimuli to the user. A set of responses discernible on the body of the user is determined, and a set of stimulus parameters for the stimulus device is calibrated based on the combination of the set of responses, the current health state, the target health state, and a trained AI-based system. A new stimulus is applied to a portion of the body of the user that shifts a condition of the user from the current health state towards the target health state.

A robotic system includes retrieval of a priori stimulus based on an input that indicates a current health state and a target health state of a user. A set of test stimuli specific for the user is determined and a stimulus device is controlled to provide the set of test stimuli to the user. A set of responses within the body of the user is determined, and a set of stimulus parameters for the stimulus device is calibrated based on the combination of the set of responses, the current health state, the target health state, and a trained AI-based system. A new stimulus is applied to a portion of the body of the user that shifts a condition of the user from the current health state towards the target health state.

The various embodiments herein disclose a method and a system with a portable handheld diagnostic device for detecting and/or monitoring the prognosis of nerve impairment or diabetic peripheral neuropathy. The system provides a multi-parameter diabetic neuropathy-screening device to perform a combination of tactile threshold test, vibration threshold test, thermal threshold test and contactless skin-temperature measurement. The present invention provides a smartphone application that helps a user to operate/control the device, store and share the results. The smartphone application interacts with the hardware modules in the device and guides the user to perform the various tests. Further, the neuropathy diagnostic system provides a wireless feedback button that enables the subject to respond to various sensations during the course of the test.

A method of modeling a nerve disposed within an intracorporeal treatment area of a patient includes locating an electrode at a plurality of locations within a virtual workspace and providing an electrical stimulus from the electrode to the intracorporeal treatment area. The response of a muscle to the electrical stimulus is monitored and used to determine a distance to the nerve from each of the plurality of locations. A virtual model of the nerve is then constructed within the virtual workspace using the determined distance to the nerve from each of the different positions, and the plurality of locations within the virtual workspace.

A device (901) is manufactured from a sheet layer (100) defining a plurality of panels (101,102,103). Each panel is connected to at least one other panel along a common edge (104). A perforation (105) extends along the common edge and defines a separation location allowing the each panel to be separated from adjoining panels when an applied force pulls each panel away from the adjoining panels. A score line (115) bisects each panel and is oriented orthogonally with the perforation. The score line allows a first portion (116) of each panel to fold about the score line to abut a second portion (117) of each panel. An adhesive (501), disposed along the first portion, retains the first portion to the second portion, as well as retains the filament between the first portion and the second portion.