The disclosed systems and methods include displaying disease trigger icons within a disease trigger map in a GUI, where the disease trigger map corresponds to a particular disease symptom, and where the position and size of a particular trigger icon within the trigger map based one or more of (i) the degree or strength of a statistical association between the trigger icon's corresponding disease trigger and the disease symptom, and (ii) a cumulative frequency and/or amount of exposure to the trigger icon's corresponding disease trigger. Some embodiments also include displaying a patient population disease trigger map one or more relationships between (i) one or more disease triggers and (ii) one or more patients of the patient population. Some embodiments may further include facilitating communication and/or disease trigger information sharing among patients.

A controller-based apparatus for diagnosis and treatment of a subject with acquired brain injury and dysfunction. Various embodiments of the invention described herein recognize that different body postures affect the autonomic nervous system differently, and therefore various external stimuli may have different therapeutic efficacies when a patient or subject is in each body posture. Postures, such as walking, sitting, standing, prone and supine, have different effects on the autonomic nervous system, and therefore some stimuli have different physiological efficacies while a patient or subject is in a given body posture. Disclosed embodiments of the present invention leverage this relationship to provide a controller-based apparatus that determines a combination of posture and stimulus that has optimal therapeutic effect, while minimizing health practitioner involvement. The controller based apparatus provides a treatment that stimulates the nervous system through a combination of noninvasive therapies that stimulate brain cells to increase their efficiency—this promotes the formation of pathways that help transfer information throughout the brain in such a way that in the end, the affected area of the brain and overall brain function are improved without medication or surgery.

Methods, systems and kits for the identification, assessment and/or treatment of a subject having multiple sclerosis are disclosed.

A method of diagnosing and monitoring biologic dysfunction may include performing measurements utilizing sensors of wireless earpieces, analyzing the measurements, comparing the measurements to established norms, determining whether the measurements indicate biologic dysfunction. The measurements may include biologic data of a user or environmental data. The sensors may include inertial sensors or optical sensors. The biologic dysfunction may include neurologic dysfunction and the neurologic dysfunction may include intention tremor. The method may include reporting the biologic dysfunction to a user.

Techniques for sensing neural responses such as Evoked Compound Action Potentials (ECAPs) in an implantable stimulator device are disclosed. A first therapeutic pulse phase is followed by a charge recovery phase that includes at least one high-impedance passive charge recovery duration. The ECAP is sensed during the high-impedance passive charge recovery duration. The time period of the passive charge recovery is lengthened and the high-impedance passive recharge duration entirely overlaps the ECAP (i.e., the neural response duration) at the sensing electrode.

A system for neuromodulation or neurostimulation comprising at least one sensing unit configured to provide a sensor signal correlating with a physiological value describing neurological function or dysfunction of a patient, at least one control unit, at least one stimulation unit, and at least one of at least one Central Nervous System stimulation module for providing Central Nervous System stimulation or at least one Peripheral Nervous System stimulation module for providing Peripheral Nervous System stimulation, wherein the control unit is configured to detect the neurological dysfunction based on the sensor signal and to trigger the neuromodulation or neurostimulation. The disclosure further relates to a method for providing neuromodulation or neurostimulation and the use of a neuromodulation system in the method for the treatment of a patient.

A typing data analysis system may be used to accurately detect early onset of CNS diseases and psychiatric disorders based on typing data. The typing data analysis system may determine typing cadence data and typing error data from typing data captured during normal, everyday typing activities including typing an email, blog, or text message. The typing cadence data and typing error data may be analyzed to determine typing based measures of different CNS diseases and psychiatric disorders. Typing based measures may be continuously determined from a patient's typing activities on the patient's personal computer, smartphone, or other commonly used device to monitor the patient's brain function over time. The typing based measures for the patient may be compared to profiles of CNS diseases and/or psychiatric disorders to screen the patient for a particular disease/disorder.

Described herein is an ocular fundus imaging apparatus (11) including and an illumination module (140) and an imaging module (141). The illumination module (140) includes light sources (103, 104) configured to generate light at wavelengths within a desired spectral range. A first optical assembly is provided to shape and direct the light onto an eye (102) of a subject. A tuneable bandpass filter (109) selects a wavelength sub-interval within the desired spectral range. The imaging module (141) includes a second optical assembly to collect light returned from the eye (102) of the subject and to project the returned light from the eye (102) onto an image sensor (113). The second optical assembly includes one or more optical elements capable of compensating for ocular variation. The image sensor (113) is configured to image the returned light to generate an image of the ocular fundus at the wavelength sub-interval.

In one embodiment, an MRI apparatus includes: a scanner that includes a static magnetic field magnet, a gradient coil, and a WB coil; and processing circuitry. The processing circuitry is configured to: cause the scanner to image, under a first imaging method, a tissue including a perfusion route of body fluid that removes waste products of the object the body fluid including neurofluid; generate an anatomical image of the tissue from first data acquired by imaging under the first imaging method; cause the scanner to image perfusion behavior of the body fluid in real time under a second imaging method using non-contrast perfusion imaging; generate a perfusion image indicating the perfusion behavior of the body fluid from second data acquired by imaging under the second imaging method; and generate a fused image by combining the anatomical image and the perfusion image.

A method for fabricating electrodes sized and dimensioned to record, measure, and/or stimulate very fine nerve structures (e.g., microscale or less) is described herein. The method can include securing a tip of an electrode, comprising a conductor substantially encased by an insulator, to a proximal portion of an inserter. The electrode can be wound around a proximal portion of the inserter and a portion of the electrode can be secured to a distal portion of the inserter. A tension in the electrode can be maintained during the winding to keep the electrode in place during the winding.