A method of manufacturing a micro-molded electrode having multiple individually addressable sensors along a shaft can include forming a recess in a mold substrate, depositing a structural material therein, depositing a conductive material at specific locations, providing a coating, and removing the mold substrate. A micro-molded electrode having a base tapering to at least one shaft can include an electrode substrate, multiple individually addressable sensors, and a coating.

A medical device comprising a memory, a processor communicably coupled to the memory, and the processor configured to execute instructions to evaluate one or more patient data inputs relating to a first specific disease, compare the one or more data inputs to a set of values from at least one database using at least one computational algorithm, train the at least one computational algorithm for estimating a diagnosis of the patient based on the first specific disease, determine a first diagnostic score for the patient for the specific disease using the at least one computational algorithm, diagnose the patient as having the specific disease when the first diagnostic score for the first specific disease is above a first value, and provide the diagnosis for the patient as an output.

A method of manufacturing a micro-molded electrode (160) having multiple individually addressable sensors (140) along a shaft (180) can include forming a recess in a mold substrate, depositing a structural material therein, depositing a conductive material at specific locations, providing a coating (190), and removing the mold substrate. A micro-molded electrode (160) having a base (170) tapering to at least one shaft (180) can include an electrode substrate, multiple individually addressable sensors (140), and a coating (190).

A method for fabricating electrodes sized and dimensioned to record, measure, and/or stimulate very fine nerve structures (e.g., microscale or less) is described herein. The method can include securing a tip of an electrode, comprising a conductor substantially encased by an insulator, to a proximal portion of an inserter. The electrode can be wound around a proximal portion of the inserter and a portion of the electrode can be secured to a distal portion of the inserter. A tension in the electrode can be maintained during the winding to keep the electrode in place during the winding.

The disclosed systems and methods include displaying disease trigger icons within a disease trigger map in a GUI, where the disease trigger map corresponds to a particular disease symptom, and where the position and size of a particular trigger icon within the trigger map based one or more of (i) the degree or strength of a statistical association between the trigger icon's corresponding disease trigger and the disease symptom, and (ii) a cumulative frequency and/or amount of exposure to the trigger icon's corresponding disease trigger. Some embodiments also include displaying a patient population disease trigger map one or more relationships between (i) one or more disease triggers and (ii) one or more patients of the patient population. Some embodiments may further include facilitating communication and/or disease trigger information sharing among patients.

A method for diagnosing, assessing or quantitating drug use, drug abuse or narcosis in a subject includes tracking eye pupil movement of at least one of a first eye and a second eye of the subject using a device suitable for tracking eye pupil movement, analyzing eye pupil movement of the at least one of the first eye and the second eye of the subject using a computer in electronic communication with the device suitable for tracking eye pupil movement, generating a plot that reflects a trajectory traveled of each of the at least one of the first eye and the second eye in response to a visual stimuli, comparing eye pupil movement of the at least one of the first eye and the second eye of the subject to a normal or mean eye pupil movement, and calculating a plurality of velocities.

A method is provided of systematically evaluating and treating dynamic autonomic dysregulation in a subject. The method includes having the subject sequentially assume a plurality of distinct postures that may include, for example, walking, standing, sitting or supine. In each posture of the subject, the subject is subjected to sensory stimulation while measuring at least one autonomic physiological response of the subject. The autonomic physiological response may include, for example, oxygen saturation, heart rate, pupillary response, blood pressure, sweat production, pseudomotor activity or respiration. The physiological responses in each of the distinct postures are evaluated to identify a posture wherein the subject exhibits a least amount of dysfunction.

Processes, scales, and devices to measure and quantify wetness perception in humans. Exemplary devices and scales utilize sensor fusion of temperature and pressure modalities, for which humans have dedicated receptors in the skin, to understand how the perception of wetness comes about. Processes test the utility of wetness perception as a biomarker for assaying peripheral neuropathy. Wetness perception devices include a Peltier module. The temperature of the Peltier module can be varied precisely using a computer-aided feedback system, mounted on a load scale to enable concomitant pressure measurements. Devices may include an insulation chamber with desiccators in place to lower internal humidity and prevent condensation. Wetness perception can be used as a non-invasive biomarker for disease-related peripheral neuropathy in which sensory mechanisms are disrupted.

A bio information measurement device and a bio information measurement method are provided. The bio information measurement device includes: a heart information acquisition unit for acquiring heart information; a brainwave information acquisition unit for acquiring brainwave information; a control unit for acquiring heart-brain synchronization information on the basis of the heart information and the brainwave information; and a display unit for displaying the heart-brain synchronization information. According to the present invention, it is possible to provide a health index reflecting the influence of both the automatic nervous system and the central nervous system.

Methods and systems useful for detecting neurological disorders and for measuring general cognitive performance, in particular by measuring eye movements and/or pupil diameter during eye-movement tasks.