A wearable device consists of a smart band and a display unit. The smart band comprises a microbial biosensor, a particulate matter sensor, an enviro sensor, a single board computer, a power supply unit, a band fastener, and a set of watch adapters. The microbial biosensor detects, measures, and monitors beneficial microorganisms and pathogens in a nasal cavity, an oral cavity, or on a surface. The microbial biosensor sterilizer kills pathogens. The particulate matter sensor detects, measures, and monitors a set of suspended particles in the surrounding air comprising beneficial microorganisms, pathogens, pollen grains, dust mite allergens, and an air quality index. The enviro sensor detects, monitors, and measures environmental conditions surrounding the user. A computing system comprises a wearable device, a microbiome mobile application, a user, a mobile device, a laboratory testing facility, a cloud server, and a physician.

A multiple test applicator has a first and second scratching barb in cooperative engagement with each other and a first and second reservoir in a fluid tray each filled with a first and second allergen. During allergen loading, the first allergen is loaded onto the first scratching barb as the second allergen is loaded onto the second scratching barb. Then, during allergen deposition the applicator is removed from the fluid tray and the first scratching barb moves laterally across the patient's skin as the second scratching barb moves laterally across the patient's skin toward the first scratching barb. The first scratching barb then scratches the epidermis at a first test site as a trace amount of the first allergen is deposited into a first site as the second scratching barb scratches a second site as a trace amount of the second allergen seeps into the second site.

A wearable device includes a housing with a window and an electronic module supported by the housing. The electronic module includes a photoplethysmography sensor, a motion sensor, and a signal processor that processes signals from the motion sensor and signals from the photoplethysmography sensor. The signal processor is configured to remove frequency bands from the photoplethysmography sensor signals that are outside of a range of interest using a band-pass filter to produce pre-conditioned signals, and to further process the pre-conditioned signals using the motion sensor signals to reduce motion artifacts from footsteps during subject running. The device includes non-air light transmissive material in optical communication with the photoplethysmography sensor and the window that serves as a light guide for the photoplethysmography sensor. The window optically exposes the photoplethysmography sensor to a body of a subject wearing the device via the non-air light transmissive material.

Disclosed are apparatuses comprising at least one electrode element having a skin-facing surface; a skin contact layer comprising an adhesive composite, and an adhesive tape or bandage. Disclosed are methods comprising positioning one or more electrode assemblies on a target site of a subject, the one or more electrode assemblies comprising at least one electrode element having a skin-facing surface; a skin contact layer comprising a conductive adhesive composite, and an adhesive tape or bandage, wherein the at least one electrode element is electrically coupled to the skin contact layer. In some aspects, the methods further comprise removing at least one of the one or more electrode assemblies from the target site of the subject after a period of time. In some aspects, after removal of the one or more electrode assemblies, the target site is evaluated for an adverse event.

The wheal and flare analyzing system analyzes the mast cell reaction to an allergen being administered in a scratch or prick skin test. The system comprises a sensor array and a processing unit. The sensor array includes a plurality of emitters surrounding a receiver at the allergen test site. Energy of various wavelengths is emitted into the allergen test site. An energy receiver measures reflected various wavelengths from the plurality of emitters. A microprocessor is in digital communication with the plurality of emitters and the energy receiver. The reflected wavelengths have an energy return indicative of the intensity of the allergic reaction in the mast cells. The intensity of the allergic reaction is analyzable from the reflected wavelengths and other data over time. A plurality of temperature sensors measuring local dermal temperatures surrounding the sensor array, the local dermal temperature being indicative of the intensity of the allergic reaction.

A system and method for non-invasive and continuous measurement of cardiac chamber volume and derivative parameters including stroke volume, cardiac output and ejection fraction comprising an ultrawideband radar system having a trans-mitting and receiving antenna for applying ultrawideband radio signals to a target area of a subject's anatomy wherein the receiving antenna collects and transmits signal returns from the target area which are then delivered to a data processing unit, such as an integrated processor or PDA, having software and hardware used to process the signal returns to produce a value for cardiac stroke volume and changes in cardiac stroke volume supporting multiple diagnostic requirements for emergency response and medical personnel whether located in the battlefield, at a disaster site or at a hospital or other treatment facility.

The present invention provides methods for determining whether a subject is allergic to an allergen, comprising administering to the subject's skin at an injection site a composition comprising the allergen, wherein the composition is administered with a microneedle delivery device; and monitoring the injection site of the subject's skin for the appearance of a hypersensitivity reaction, wherein the appearance of the hypersensitivity reaction indicates that the subject is allergic to the allergen.

A method comprising a wearable device which consists of a smart band and a display unit. The smart band comprises a microbial biosensor, a particulate matter sensor, an enviro sensor, a single board computer, a power supply unit, a band fastener, and a set of watch adapters. The microbial biosensor detects, measures, and monitors beneficial microorganisms and pathogens in a nasal cavity, an oral cavity, or on a surface. The microbial biosensor sterilizer kills pathogens. The particulate matter sensor detects, measures, and monitors a set of suspended particles in the surrounding air comprising beneficial microorganisms, pathogens, pollen grains, dust mite allergens, and an air quality index. The particulate matter sensor sterilizer kills pathogens. The enviro sensor detects, monitors, and measures environmental conditions surrounding the user.

The present invention provides a method for generating an immune response in a subject, comprising administering to the subject’s skin an immunizing composition comprising one or more cancer antigens, wherein the composition is administered with a microneedle delivery device.

The present disclosure provides methods for enabling an individual having a cat allergy to have a cat as a pet. Such a method can include quantitatively determining a threshold in the individual for an environmental level of an allergen produced by the cat and selecting a cat or a breed of cat that creates an environmental level of the allergen that is less than the threshold. Additionally, such a method can include lowering the allergens disseminated by the cat by treating the environment inhabited by the cat during a time period where the cat expresses elevated allergens.