The invention provides an implantable device and method of monitoring wirelessly and continuously thermal conductivity and blood flow on the surface of a target region of a subject. The implantable device comprises a probe operably attached to the target region; and an electronic module coupled with the probe for wireless, real-time, and continuous measurements of physiological information of the target region.

A method and system for continually monitoring oxygenation levels in real-time in compartments of an animal limb, such as in a human leg or a human thigh or a forearm, can be used to assist in the diagnosis of a compartment syndrome. The method and system can include one or more near infrared compartment sensors in which each sensor can be provided with a compartment alignment mechanism and a central scan depth marker so that each sensor may be precisely positioned over a compartment of a living organism. The method and system may comprise hardware or software (or both) may adjust one or more algorithms based on whether tissue being monitored was traumatized or is healthy. The method and system can also monitor the relationship between blood pressure and oxygenation levels and activate alarms based on predetermined conditions relating to the oxygenation levels or blood pressure or both.

Methods and apparatus are used to assess the viability of tissue such as flap tissue. According to one aspect of the present invention, a method for assessing the viability of flap tissue includes obtaining an oxygen saturation level associated with a first location on the flap tissue, determining whether the oxygen saturation level is less than a first level, and identifying the first location as having a poor blood supply if the oxygen saturation level is less than the first level.

The present disclosure provides methods and systems for predicting a subject's diagnostic status with respect to a disease or disorder. The method may comprise exposing a biological sample of the subject to a laser, acquiring a plurality of Raman spectra from the exposed biological sample, processing the plurality of Raman spectra to generate a spatial map of the plurality of Raman spectra, and predicting a subject's diagnostic status with respect to disease or disorder based at least in part on the spatial map of the plurality of Raman spectra. The analyzing may comprise determining temporal dynamics of underlying biological processes.

An apparatus for determining heart transplant rejection of a heart in a patient includes at least two electrodes adapted to be sewn into the heart that span the left ventricle. The apparatus includes a voltage generator adapted to be inserted in the patient which generates a voltage to the two electrodes and senses the resulting voltage from the two electrodes. A method for determining heart transplant rejection of a heart in a patient. A pacemaker for a patient (including bi-ventricular pacing and AICDs). The pacemaker includes an RV lead having four electrodes adapted to be inserted into the RV apex. The pacemaker includes a voltage generator which generates a voltage signal to the electrodes and senses the instantaneous voltage along the length of the RV and determines the real and imaginary components to remove the myocardial components of the septum and RV free wall to determine absolute RV blood volume. The pacemaker includes a battery connected to the voltage generator. The pacemaker includes a defibrillator connected to the battery. The pacemaker can also be a bi-ventricular pacemaker to restore RV and LV synchrony during contraction. A method for assisting a heart of a patient.

Provided herein is a method for monitoring vital signs of a post-operative organ transplant patient, comprising collecting patient information, selecting a wearable device, and monitoring real time vital signs data using the wearable device, comprehensively harmonizing the acquired real-time vital signs data, and storing the comprehensively harmonized vital signs data; periodically retrieving the vital signs data of the patient, verifying and correcting the vital signs data of the patient using a data verification and correction algorithm, and processing and analyzing the verified and corrected vital signs data of the patient to generate a health status report of the patient; and encrypting the health status report of the patient using a health security encryption technology, and introducing a fast and secure transmission method.

An donor organ viability instrument (1000) includes an in situ donor organ interrogation module with a positioned photoacoustic array (1008). This array, tailored for the organ type and viability factors, performs computational photoacoustic imaging to generate viability data for the donor organ (1028) in its natural location. In some implementations, the instrument includes an ex vivo donor organ interrogation module (4000) with a stationary photoacoustic array (1007). This array, also tailored for the organ type and viability factors, performs computational photoacoustic imaging and multispectral scanning on an organ placed in an acoustic coupling nest (4016). Additionally, it includes sensors for gravimetric, dimensional, and environmental measurements to assess organ viability. In certain implementations, the apparatus includes a predictive model with machine learning algorithms trained on a plurality of feature signals (6002) and corresponding organ responses (6004).