Methods and materials used for production of constructs having a porous open or semi-open celled structure. Constructs may include a porous matrix as a base and a biocompatible conformal coating thereon.

The present invention is related to the use of ethylene alkanoate-alkyl acrylate bipolymers with a high randomness monomers distribution, which are synthesized by semicontinuous emulsion polymerization process, characterized because it is carried out using slow addition rate of the pre-emulsion feeding ({dot over (q)}≤0.009 kg.Math.L.sup.−1.Math.min.sup.−1), stabilized this last one by alkyl glycol ether type surfactants, at temperatures higher than 75° C. and with solids contents above 25 wt %, which avoids the formation of large sequences (blocks) of a same monomer. This structural characteristic gives the ethylene alkanoate-alkyl acrylate bipolymers a high efficiency as chemical agents for removal of complex water/crude oil emulsions of crude oil blends.

The present invention is related to the use of ethylene alkanoate-alkyl acrylate bipolymers with a high randomness monomers distribution, which are synthesized by semicontinuous emulsion polymerization process, characterized because it is carried out using slow addition rate of the pre-emulsion feeding ({dot over (q)}≤0.009 kg.Math.L.sup.−1.Math.min.sup.−1), stabilized this last one by alkyl glycol ether type surfactants, at temperatures higher than 75° C. and with solids contents above 25 wt %, which avoids the formation of large sequences (blocks) of a same monomer. This structural characteristic gives the ethylene alkanoate-alkyl acrylate bipolymers a high efficiency as chemical agents for removal of complex water/crude oil emulsions of crude oil blends.

Provided is a bone regenerative agent which can repair a bone defect site with preventing from remaining at the bone defect site. The bone regenerative agent comprises zinc subcarbonate containing hydrozincite. It is preferred that the zinc subcarbonate has a Zn2+ ion elution amount of 0.1 ppm by mass or more after an elution test and also has a pH value of 7.2 or more and less than 8.3 after an elution test. It is preferred that some carbonate ions in the hydrozincite are substituted by sulfate ions or chloride ions. It is preferred that the bone regenerative agent is applied to a bone defect site.

Provided is a bone regenerative agent which can repair a bone defect site with preventing from remaining at the bone defect site. The bone regenerative agent comprises zinc subcarbonate containing hydrozincite. It is preferred that the zinc subcarbonate has a Zn2+ ion elution amount of 0.1 ppm by mass or more after an elution test and also has a pH value of 7.2 or more and less than 8.3 after an elution test. It is preferred that some carbonate ions in the hydrozincite are substituted by sulfate ions or chloride ions. It is preferred that the bone regenerative agent is applied to a bone defect site.

Microlaser based dye doped polymeric resonators are provided as well as pharmaceutical formulations containing the microlaser based dye doped polymeric resonators, methods of making thereof, and methods of use thereof for monitoring and/or stimulating electrical activity in a brain of a subject in need thereof. The microlaser based dye doped polymeric resonators can include a particle having a spherical core containing one or more fluorescent dyes dispersed within a polymer matrix, wherein the polymer matrix has an index of refraction of about 1.2 or greater; an outer surface surrounding the spherical core; and a gold nanoparticle, wherein the gold nanoparticle is on the outer surface, is dispersed within the spherical core, or both. The fluorescent dyes can include a voltage sensitive fluorescent dye.

Microlaser based dye doped polymeric resonators are provided as well as pharmaceutical formulations containing the microlaser based dye doped polymeric resonators, methods of making thereof, and methods of use thereof for monitoring and/or stimulating electrical activity in a brain of a subject in need thereof. The microlaser based dye doped polymeric resonators can include a particle having a spherical core containing one or more fluorescent dyes dispersed within a polymer matrix, wherein the polymer matrix has an index of refraction of about 1.2 or greater; an outer surface surrounding the spherical core; and a gold nanoparticle, wherein the gold nanoparticle is on the outer surface, is dispersed within the spherical core, or both. The fluorescent dyes can include a voltage sensitive fluorescent dye.

Non-sensitizing pressure sensitive adhesives which are useful in medical applications and other uses where an adhesive is in contact with skin are obtained by energy-curing compositions containing one or more acrylate-functionalized compounds and possibly other components which are selected such that the cured adhesive passes an in vitro cytotoxicity test in accordance with ISO 10993-5 (2009).

Non-sensitizing pressure sensitive adhesives which are useful in medical applications and other uses where an adhesive is in contact with skin are obtained by energy-curing compositions containing one or more acrylate-functionalized compounds and possibly other components which are selected such that the cured adhesive passes an in vitro cytotoxicity test in accordance with ISO 10993-5 (2009).

An optical assembly (200) including an encapsulated multilayer optical film (250). Methods of making and using such optical assemblies also are disclosed.