The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer haying an absorption maximum ranging from 400 nm to 800 nm; and at least one CH-acidic compound as coinitiator.

The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer haying an absorption maximum ranging from 400 nm to 800 nm; and at least one CH-acidic compound as coinitiator.

The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

The present invention discloses bioengineered corneal grafts for treating either or both Keratoconus and visual impairment, selected from (i) a corneal Onlay comprises or coated by at least one member of Group A, consisting of biocompatible synthetic materials; at least one member of Group B, consisting of at least one type of biological polymer and optionally, at least one member of Group C, consisting of at least one type of protein and (ii) An intrastromal corneal lenticule graft, configured to mimic native corneal stroma tissue by means of its optical properties, mechanical properties, permeability and interaction with corneal stromal cells; wherein at least one portion of said lenticule comprises or coated by at least one member of Group D, consisting of transparent crosslinked hydrogel; at least one member of Group E, consisting of collagen; collagen methacrylate, recombinant mammal collagen, mammal-sourced collagen; and optionally, at least one member of Group F, consisting of Keratocytes and/or stem cells and any combination thereof. The present invention further discloses compositions, methods for production, implementation and treatment of medical indications by aforesaid corneal graft.

A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.

A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.

The present invention relates to a composition comprising two compounds based on triazine-trione (TATO) comprising at least one thiol group and at least one unsaturated carbon-carbon bound and where the composition further comprises an amine group or compound and a Type I photoinitiator. The composition may be used for treating teeth and bone.

The present invention relates to a composition comprising two compounds based on triazine-trione (TATO) comprising at least one thiol group and at least one unsaturated carbon-carbon bound and where the composition further comprises an amine group or compound and a Type I photoinitiator. The composition may be used for treating teeth and bone.

[Object] To provide a dental adhesive composition that is highly adhesive to both porcelain and a tooth substance, an acid monomer, water, and a silane coupling agent coexisting in the dental adhesive composition, the dental adhesive composition being usable as a one-liquid type adhesive and exhibiting high preservation stability as a one-liquid type adhesive even after long-term preservation, regardless of the type of acid monomer used.

[Solving Means] There is provided a dental adhesive composition characterized by including a mixture that includes a silane coupling agent (A) that does not have a silyl ether structure and includes an organic silane compound (a1) in which four monovalent groups are bonded to one silicon atom, the four monovalent groups including (i) a monovalent group having a radical polymerizable group and (ii) a monovalent group that has an alkylene chain having 3 to 40 carbon atoms and an unsaturated bond in a carbon atom at a β-position from the silicon atom; a fluoride salt (B); a polymerizable monomer (C) that contains an acidic group-containing polymerizable monomer (c1); water (D); and an organic solvent (E).

[Object] To provide a dental adhesive composition that is highly adhesive to both porcelain and a tooth substance, an acid monomer, water, and a silane coupling agent coexisting in the dental adhesive composition, the dental adhesive composition being usable as a one-liquid type adhesive and exhibiting high preservation stability as a one-liquid type adhesive even after long-term preservation, regardless of the type of acid monomer used.

[Solving Means] There is provided a dental adhesive composition characterized by including a mixture that includes a silane coupling agent (A) that does not have a silyl ether structure and includes an organic silane compound (a1) in which four monovalent groups are bonded to one silicon atom, the four monovalent groups including (i) a monovalent group having a radical polymerizable group and (ii) a monovalent group that has an alkylene chain having 3 to 40 carbon atoms and an unsaturated bond in a carbon atom at a β-position from the silicon atom; a fluoride salt (B); a polymerizable monomer (C) that contains an acidic group-containing polymerizable monomer (c1); water (D); and an organic solvent (E).