According to the invention, there is provided a light-based skin treatment device comprising a treatment light source; a treatment light exit window via which, during operation, treatment light generated by the treatment light source is applied to skin of a user, wherein the treatment light exit window comprises an optically transparent material arranged to contact the skin during operation; and an imaging unit comprising an image sensor 5 arranged to generate an image of the skin during operation. The skin treatment device further comprises an optical waveguide comprising a treatment light receiving surface, an imaging light exit surface and a main surface, wherein said treatment light receiving surface is arranged to receive the treatment light so that the treatment light enters the waveguide at the treatment light receiving surface; said main surface comprises the treatment light exit 10 window and is arranged to transmit the treatment light so that the treatment light exits the waveguide at the treatment light exit window; said imaging light exit surface is arranged with respect to the main surface to receive light reflected at the main surface by total internal reflection at positions where, during operation, no skin is in contact with the main surface; said image sensor is arranged to receive from the imaging light exit surface light which is 15 guided by total internal reflection from the main surface towards the imaging light exit surface.

The invention relates to a device (1) and an according method for optoacoustic imaging of an object. The device (1) comprising an irradiation unit for irradiating a region of interest (3) of the object with electromagnetic radiation (6), in particular light, and a detection unit (9) for detecting acoustic, in particular ultrasonic, waves generated in the region of interest (3) of the object upon irradiation with the electromagnetic radiation (6), wherein the detection unit (9) is configured to detect the acoustic waves at one or more point-like detection locations, which are located outside of the region of interest (3) of the object. The point-like detection locations can be given by, e.g., focus points (19) of acoustic detection elements (23), point-like detection elements or point-like or pinhole apertures. The invention allows for improved and reliable optoacoustic imaging, in particular in view of dermatology applications.

Disclosed herein is a non-invasive system for determining tissue composition. The system comprises an imaging system with a non-invasive probe, a signal analyzer, and a correlation processor. The probe includes active imaging components for emitting energy and collecting imaging data including reflected signals from an object of interest. The signal analyzer analyzes the imaging data and determines one or more signal properties from the reflected signals. The correlation processor then associates the one or more signal properties to pre-determined tissue signal properties of different tissue components through a pattern recognition technique wherein the pre-determined tissue signal properties are embodied in a database, and identifies a tissue component of the object based on the pattern recognition technique.

Devices that take a novel approach to parameter measurement and output or transmission of signals, medicine, heat, etc. These devices are compact, versatile, relatively inexpensive, and require minimal training to be effectively used. These devices can be configured as interchangeable devices incorporated into a wearable article or device.

A plurality of light sources placed at one end of a surface imaging system may generate and direct light rays to be incident onto a surface to be detected at high incident angles that are greater than or equal to a predetermined angle threshold, the predetermined angle threshold may be set to ensure that images of the surface to be detected that have at least a predetermined degree of contrast are to be obtained. An image sensor that is placed at another end of the surface imaging system may collect light rays reflected from the surface to be detected to form a first image of the surface to be detected.

There is shown and described a deep learning based system and method for skin diagnostics as well as testing metrics that show that such a deep learning based system outperforms human experts on the task of apparent skin diagnostics. Also shown and described is a system and method of monitoring a skin treatment regime using a deep learning based system and method for skin diagnostics.

A viewing navigation grid and imaging display especially useful for viewing recorded skin images.

The present invention provides phase separation sensors capable of targeting or associating with one or more biomolecular condensate or membraneless compartment in cells. The phase separation sensors comprise at least two domains wherein a first domain comprises one or more accessory protein or molecule and a second domain comprises an artificial client protein or intrinsically disordered sequence. The artificial client protein possesses intrinsic disorder and is capable of engaging in ultra-weak phase separation-specific interactions with one or more component protein or molecule in a biomolecular condensate. Methods and applications utilizing the sensors are provided including targeting, detecting, visualizing, manipulating, monitoring a biomolecular condensate and delivering one or more functional protein, label, drug or agent to a biomolecular condensate.

The present invention discloses a device for acquiring a functional image of tissue and a method for acquiring a functional image by using same, the device comprising: a light source for irradiating a tissue to be imaged with coherent light; an image acquisition unit for acquiring an image of a speckle pattern which is formed by scattering the light emitted from the light source over the tissue, and acquiring multiple images having different exposure times; an image processing unit for generating a functional image of the tissue on the basis of the multiple images acquired by the image acquisition unit; and a control unit for adjusting the light quantity of the light emitted to the tissue such that the multiple images having different exposure times have brightness values in a common range, and controlling the operation of the image acquisition unit.

Instruments and methods for wide-field polarized imaging of the skin to determine an outer lesion margin objectively in vivo to provide guidance to a surgeon. Quantitative characterization of collagen structures in the skin can be used to determine the outer lesion margin or monitor skin treatment.