Systems and methods are provided for adjusting a standing insulin medicament dosage regimen for a subject. Fasting events are identified using autonomous timestamped glucose measurements of the subject in a first data set. A second data set, from one or more insulin pens used to apply the standing regimen, comprises records, each record comprising a timestamped event specifying an amount of injected insulin medicament. Each fasting event is characterized as adherent or nonadherent. A fasting event is adherent when the second data set includes one or more records that temporally and quantitatively establish adherence with the standing regimen during the fasting event. Conversely, a fasting event is nonadherent when the second data set fails to temporally and quantitatively establish adherence with the standing regimen. Dosages in the standing regimen are adjusted using glucose measurements contemporaneous with adherent fasting events and by excluding glucose measurements contemporaneous with nonadherent fasting events.

Apparatus and associated methods relate to a connected pill dispenser configured to treat a patient's illness with a robotic arm adapted to deliver a prescribed medication dose to a patient in their home, analyze the patient's response to the dose based on various sensor inputs, automatically determine whether the patient took the medicine and send the provider the result of providing the medication dose to the patient. In an illustrative example, the patient may be a chronic, acute, or terminal illness patient. The medication dose may be, for example, a medication prescribed by a doctor to be taken in a specific amount at specific times. In some embodiments, the connected pill dispenser may automatically notify the patient when a medication dose is due. Various embodiments may determine if the patient consumed a medication dose based on machine vision, audio, or other sensor data, permitting caregiver notification of patient medication adherence, medication compliance, or non-adherence and sensor inputs as data on potential effectiveness and/or side effects.

To enable detection of a plurality of capsule ingestions, the ingestible capsules include a transmitter and processing hardware to generate and transmit the signals. Each ingestible capsule obtains a serial number for distinguishing between the ingestible capsules, and generates a signal indicating that the capsule has been ingested. The signal includes a series of pulses having a particular pulse space and indicating the serial number. Each ingestible capsule transmits the signal to a receiver via the transmitter, where each ingestible capsule is identified based on at least one of: the particular pulse space and the serial number for the ingestible capsule.

Various methods and systems are provided for a patient monitoring compliance system. In one embodiment, a method includes determining, over a duration, a relative amount of monitored time where data from the one or more monitoring devices was usable for monitoring one or more parameters of a patient, and if the relative amount of monitored time is less than a threshold amount of monitored time, outputting a first notification.

Provided is a system including a plurality of inhalers that each include a processor configured to determine a value of a usage parameter relating to use of the respective first inhaler, encrypt data based on the value, and transmit the encrypted data. At least two of the inhalers include different medicament, such as a rescue medicament and a maintenance medicament. The system includes an external device that includes a processor configured to distinguish between the encrypted data of each respective inhaler, determine respective usage information relating to each of the distinct types of medicament based on the respective encrypted data, and control a user interface (e.g., of the external device) to communicate the usage information related to each inhaler and/or each respective type of medicament.

Provided is a pharmaceutical agent for effective prophylaxis and/or treatment of a pathological condition with decreased lung compliance. The pharmaceutical agent for prophylaxis and/or treatment of a pathological condition with decreased lung compliance is characterized by having a polyamine. The polyamine includes at least one of spermine (Spm), spermidine (Spd), and putrescine (Put). The pharmaceutical agent improves lung compliance and ameliorates gas exchange dysfunction, and therefore, can ameliorate pathological conditions such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), lung diseases caused by dysfunctional endogenous pulmonary alveolar surfactant, multiple organ dysfunction syndrome (MODS), and cardiogenic pulmonary edema.

The present technology relates to one or more of the screening, diagnosis, monitoring, treatment, prevention and amelioration of respiratory-related disorders. The present technology also relates to medical devices or apparatus, and their use. In particular, the present technology a headgear for supplying pressurised air to a patient, comprising a headgear tubing which is inflatable from a collapsed state to an inflated state to form a conduit for supplying pressurised air to the patient, and when the headgear tubing is in the collapsed state, the headgear tubing is elastically deformable and foldable on itself. The headgear may further comprise a rigidiser.

In one aspect, an electronic device for promoting proper use of a walking aid during lower extremity injury rehabilitation comprises at least one load sensor configured to measure a load on the walking aid. A memory stores rehabilitation program data defining at least one time interval of a rehabilitation period and, for each time interval, a target load for the walking aid during the time interval. A currently operative time interval of the at least one time interval of the rehabilitation period is identified. Data is received, from the load sensor(s), indicative of a dynamic load on the walking aid during a patient step. Based upon the received data, a peak load upon the walking aid during the patient step is determined. A user notification indicating that the peak load is non-compliant with the target load for the walking aid for the currently operative time interval is provided.

Embodiments described herein are directed to non-invasive detection of peripheral arterial disease. For example, a measuring apparatus is used to measure a patient's calf circumference. The measuring apparatus has text feature(s) or indicator(s) printed thereupon that indicate the likelihood that the patient has peripheral arterial disease based on the measured calf circumference. The assessment may be further refined by using a software application that assesses the likelihood of the patient having peripheral arterial disease using at least the calf circumference measurement, along with other information/data. Based on the assessment, a healthcare practitioner may prescribe a walking program for the patient to follow. A software application may track compliance of the walking program and provide escalating reminders to the patient if the patient continues to fail to comply with the prescribed walking program.

Embodiments of systems and methods for monitoring use of an orthopedic device are at least disclosed. In some embodiments, the system can include an orthopedic device, a housing, and a controller. The orthopedic device can provide support to a limb of an individual. The orthopedic device can include a magnet configured to generate a magnetic field. The housing can attach to the individual, and the housing can support a magnetometer configured to generate a signal responsive to the magnetic field. The controller can determine from the signal whether the individual is using the orthopedic device to provide support to the limb and accordingly output usage indications.