A method and apparatus for tracking disease progression as revealed by multiple lesions perform a global optimization to identify corresponding lesions by overlap, for example, after outlines of the lesions have been morphologically dilated. A clustering algorithm addresses the problem of lesions separating into parts or joining together to provide a clear picture of disease progression.

The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

Devices and methods for predicting, identifying and/or managing pneumonia are disclosed and may generally comprise a housing, a mouthpiece in communication with the housing and configured for insertion within a mouth, a temperature sensor positioned within or along the housing, a pulse oximeter sensor positioned along the housing for sensing a heart rate or blood oxygen level, a microphone positioned within or along the housing for obtaining sounds associated with respiration, and a controller configured to receive physiologic parameters including the temperature, heart rate, blood oxygen level, and sounds associated with respiration. The controller can determine a likelihood of contracting pneumonia, a presence of pneumonia, or a status of pneumonia within the user based on deviations from a threshold value which are present in at least two of the physiologic parameters.

The present method and system provides a neuromodulation therapy including receiving a plurality of input data relating to a patient, the input data including brain value measurements. The method and system includes analyzing the input data in reference to reference data generated based on machine learning operations associated with existing patient data and reference database data. Based thereon, the method and system includes electronically determining, a brain malady and a severity value for the patient and electronically generating a treatment protocol for the patient, the treatment protocol includes transcranial stimulation parameters. Therein, the method and system includes applying a transcranial stimulation using the transcranial stimulation parameters based on the treatment protocol.

The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

In a microrunner structure, there are provided with components for a cleaning procedure required to conduct electrochemical sensing when a biosensor is activated for sensing; and a urine signal detection device that is a SoC (System on a Chip), which has a wireless transceiving circuit for receiving a urine measurement method and channel information transmitted from an intelligent device, and in turn, outputting a stimulus signal to trigger a biosensor or a non-biosensor in a multi-channel structure to conduct urine sense processing for a sensing area, as well as transmitting detection processing for a concentration of urine substances from the electrochemical sensing to the intelligent device through the wireless transceiving circuit to assess a risk index between a heart disease or diabetes and a kidney disease.

The present invention provides a system for personalized skin health and/or appearance regimen supported with a device that comprises a mirror-based digital interface apparatus, directly from the device to one's account. In some embodiments, the device utilizes built-in virtual trainers/beauticians to give realtime personalized suggestions, product recommendations, based on the user's preference. The trainer/beautician can provide information through text on the screen or use audio. In some embodiments, it can display personalities, influencers, skin health experts who suggest skin workout regiment and them using the mirror-based digital interface. In some embodiments, realtime questions can be asked and answered with a data library integrated within the device and online database.

An emotional or mental belief system reprogramming system is disclosed. The system includes a digital framework including a pattern recognition module configured to identify and recommend reprogramming and alter a health status of a user, the digital framework includes (1) a digitally recorded library of human emotions, unconscious agendas, perceptions, beliefs, and mindsets of a control group of users selected from a population of users (2) a question engine configured to interrogate the user using a library of predetermined questions and to identify a plurality of underlying unconscious agendas of the user that generate behavior of the user and associated negative emotions of the user, (3) an expressive, experiential digital agent having digitized color, gestures, expressions, movements, emotions, beliefs, intent, intuition, and haptic effects, the digital agent configured to interact with the user in real time, to ask questions, to engage the user.

A blood-purification-treatment support system is capable of making an accurate judgement of whether or not any treatment conditions for blood purification treatment should be changed. The blood-purification-treatment support system is capable of supporting blood purification treatment. The system includes a storage device that stores patient-specific patient data that are acquired on a plurality of days including at least no-treatment days on which blood purification treatment is not conducted, an estimating device that compares the patient data for the plurality of days stored in the storage device with one another and estimates a pre-treatment patient state regarding blood purification treatment, and a judging device that judges from the pre-treatment patient state estimated by the estimating device whether or not any treatment conditions for blood purification treatment should be changed.

Systems and methods for lean muscle mass monitoring of patients and for identifying and treating at least one of Cachexia or Sarcopenia are disclosed. The system may include a dynamometer provided to patients, the dynamometer being configured to perform remote monitoring. The dynamometer may be used and data may be collected by patients without the supervision of a healthcare professional. Using the collected data, lean muscle mass may be tracked over time, to provide fast and accurate assessment of conditions. Using such an assessment, early treatment options can be targeted to patients to avoid progression into various disease states, for examples, more severe states of at least one of Cachexia or Sarcopenia.