The present invention relates to sleepiness assessment. In order to provide a more accurate measure to predict OSA severity, an apparatus is provided for sleepiness assessment. The apparatus comprises an input unit, a processing unit, and an output unit. The input unit is configured to receive data indicative of an activity currently performed by a user. The processing unit is configured to determine, based on the activity currently performed by the user, a current situation the user is engaging in. The processing unit is configured to determine whether the current situation matches one of a plurality of pre-determined situations used for situational sleepiness assessment. In response to the determination that the current situation matches one of the plurality of predetermined situations, the processing unit is configured to send a notification to the user for a self-report of a user's current subjective sleepiness level and/or obtain a user's current objective sleepiness level from sensor data. The processing unit is further configured to generate, based on the determined situation and the user's current subjective and/or objective sleepiness level, a situational sleepiness profile indicative of a sleep disturbance on daytime sleepiness in specific situations. The output unit is configured to provide the generated situational sleepiness profile, which is preferably useable to support sleep apnea diagnostics.

An embodiment of a method for assessing cardiovascular disease in a user with a body region using a mobile computing device including a camera module, includes receiving a time series of image data of a body region of the user, the time series of image data captured during a time period; generating a photoplethysmogram dataset from the time series of image data; generating a processed PPG dataset; determining a cardiovascular parameter value of the user based on the processed PPG dataset; fitting a chronobiological model to (1) the cardiovascular parameter value, and (2) a subsequent cardiovascular parameter value, characterizing a cardiovascular parameter variation over time of the user based on the fitted chronobiological model; and presenting an analysis of the cardiovascular parameter variation to the user at the mobile computing device.

Systems, methods, and computer program products are disclosed that can receive temperature data from at least one temperature sensor over a period of time. At least one metric of the temperature data can be calculated, which may utilize the temperature data from a particular sensor over the period of time and may be indicative of variability in the temperature data. A tissue assessment can be determined by utilizing a classifier with at least one feature input to the classifier, the feature(s) being determined from the metric(s).

Systems, eye-mountable devices, and methods that facilitate chronotherapeutic treatment of primary open-angle glaucoma are provided which enable therapeutic products to be delivered to the eye in a controlled manner only when desired. According to one embodiment, an eye-mountable device comprises a substrate having an eye-mounting surface for positioning on an eye of a patient, a sensor that obtains a plurality of measurements representative of a condition of the eye of the patient over a period of time, a therapeutic agent delivery assembly coupled, and a processor for executing a temporal model of a therapeutic agent delivery in communication with the sensor and the therapeutic agent delivery assembly. The processor receives the plurality of measurements and activates the therapeutic agent delivery assembly to administer a first amount of a drug to the eye of the patient based on the temporal model associated with the plurality of measurements.

The present disclosure provides a circadian rhythm correcting apparatus including a bio-illuminance measuring part configured to measure bio-illuminance of external light, a light source configured to irradiate light of a circadian wavelength band toward a retinal ganglion cell, a light source driver configured to drive the light source by supplying power to the light source, and a controller configured to control the light source driver on the basis of the bio-illuminance measured by the bio-illuminance measuring part, to correct the circadian rhythm.

Methods for identifying responders to agents that increase brain dopaminergic neuronal activity for the treatment of metabolic and cardiovascular disease and for treating elevated heart rate and metabolic disease or dysglycemia in subjects with type 2 diabetes.

Systems and methods are provided for using stored physiologic information about a subject to detect a previous treatment event. Physiologic information can be sensed from a subject using one or more sensors. Using a detection circuit, a change in the sensed physiologic information, such as a change from reference physiologic information, can be used to identify a candidate previous treatment event. An alert or other information about the candidate treatment event can be provided to a patient or clinician. In an example, a candidate treatment event can include a heart failure or diuresis treatment that is identified using information about a change in one or more of a subject's circadian pattern, a subject's thoracic impedance, or a subject's respiration status.

A system embodied in an article of clothing for synchronizing one or more breast-pumping sessions of an individual (such as a mother) and milk consumption by a second individual (such as a baby or infant) is described. In particular, based on measurements of a volume of the collected milk as a function of time and received information specifying milk consumption by the second individual as a function of time, a control circuit may determine a need for milk. Then, the control circuit may provide feedback based on the determined need for milk that synchronizes the one or more breast-pumping sessions and the milk consumption. For example, the feedback may alert the individual to initiate a breast-pumping session and/or may provide a signal to a breast pump that initiates a breast-pumping session.

An analysis system for analysis of the balance of circadian heart rhythm autonomic nervous system, the analysis system having tools which are designed to perform the following steps after artifact and arrhythmias removal from RR interval series: identification of the chaotic part of the RR interval series and analysis of the chaotic part; separation of the chaotic part from RR interval series and acquisition of the clean circadian RR series; acquisition of the normalized RR interval series using—interpolation, resampling and normalization; analysis of the heart rate bimodal distribution and modes of the normalized RR interval series; identification of the heart rate circadian period in the normalized RR data series; analysis of the heart rhythm variable part SNS and PNS regulation indicators in the normalized RR data series; generation of the report on obtained results in graph and tabular form.

A non-transitory computer-readable recording medium stores a driving support program that causes a computer to execute a process including: collecting vital sign information on a user from a vital sign measuring device; generating a drowsiness occurrence time pattern with respect to the user based on the collected vital sign information; and in response to a request in which a driver is specified from a source of the request, providing the drowsiness occurrence time pattern that is generated with respect to the user corresponding to the driver to the source of the request to the source of request or providing alerting information to the driver that is determined according to the drowsiness occurrence time pattern generated with respect to the user corresponding to the driver to the source of request.