Infusion devices and related medical devices, patient data management systems, and methods are provided for monitoring a physiological condition of a patient. An exemplary infusion device includes an actuation arrangement operable to deliver fluid to a user, a communications interface to receive measurement data indicative of a physiological condition of the user, a sensing arrangement to obtain contextual measurement data, and a control system coupled to the actuation arrangement, the communications interface and the sensing arrangement to determine a command for autonomously operating the actuation arrangement in a manner that is influenced by the measurement data and the contextual measurement data and autonomously operate the actuation arrangement in accordance with the command to deliver the fluid to the user.

Embodiments provide physiological measurement systems, devices and methods for continuous health and fitness monitoring. A wearable strap may detect reflected light from a user's skin, where data corresponding to the reflected light is used to automatically and continually determine a heart rate of the user. The wearable strap may monitor heart rate data including heart rate variability, resting heart rate, and sleep quality. The systems may include a processing module that generates an indicator of physical recovery based on the heart rate data. The recovery indicator may be used to determine strain related to an exercise routine, qualitative information on the user's health, whether to alter a user's exercise plan, and so forth.

Embodiments relate to systems and methods for informing, determining, or controlling insulin dosage. The method involves generating plural disturbance profiles, each disturbance profile being a data representation based on historical patient data pertaining to a deviation from a threshold blood glucose level. The method involves receiving current patient data. The method involves applying a predictive model so that current patient data is compared to a disturbance profile and a probability analysis is used to assess the likelihood of a disturbance profile being an anticipated disturbance profile, the anticipated disturbance profile being a disturbance profile that is determined to match with the current patient data based on the probability analysis. The method involves determining an insulin dose amount based on the anticipated disturbance profile. The method involves outputting a signal representative of the insulin dose amount to a device configured for monitoring, influencing, and/or administering insulin levels in the patient.

A system and a method for predicting kinesthetic outcomes from observed position, posture, behavior or activity of an individual 1602, 1702. The system uses kinesthetic activity sensors 102, 104 each collecting one or more of audio, video, or physiological signals and capturing the activity of the individual or an ambient environment of the individual. These signals are delivered into a computer system 106 implementing a learning routine 108 which constructs one or more personalized kinetic state models 1510 of positional states for the individual and transitions between the positional states, and further develops one or more customized multi-dimensional prediction models 1500 for the individual and uses the multidimensional prediction models to predict behaviors, activities and/or positional changes likely to occur in the future, and provides notice of predicted unsafe or undesired outcomes.

A system includes a minimally intrusive display system (MIDS) configured to be disposed on an eyewear. The MIDS includes a display system and a sensor system configured to provide for a sensor data. The MIDS further includes a processor configured to process the sensor data to derive a physiological measure. The processor is further configured to display, via the display system, the physiological measure, wherein the display system is disposed in the eyewear so that the physiological measure is only viewed when a user of the eyewear turns the user's pupil towards the display system at angle α from a forward direction.

A pulse sensor is capable of measuring a pulse rate of a wearer at a peripheral artery. In an embodiment, the pulse sensor includes a magnet supported to move responsive to an arterial pulse and a magnetometer configured to detect changes in a magnetic field produced by the magnet. The magnet may include a plurality of ferromagnetic particles disposed in or on a flexible substrate configured to be held adjacent to human skin subject to arterial palpation and a magnetic sensor configured to sense movement of the ferromagnetic particles. A system and method may measure hydration includes using a pulse sensor to measure pulse rate and modulation. The wearer is prompted when the pulse rate and pulse modulation indicate a response to dehydration of the wearer.

An apparatus is described for measuring hemodynamic or metabolic function of an organ or tissue region of a subject comprising a super-continuum laser operating in the near or short-wave infrared wavelength range and comprising a multi-stage amplifier. A source fiber delivers the super-continuum emission to the organ or tissue region, and a collection fiber receives reflected emission from the region. A detector followed by a processor is used to determine a metabolic state and an oxygenation state of the organ or tissue region. A signal-to-noise ratio of the signal is improved using a dual-arm differential measurement technique.

Described herein are positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) systems and methods of use. In one example, a PET-EPRI system includes a PET-EPR insert, a PET scanner including one or more solid-state photodetectors, and a subject module that can house a subject for scanning. The PET-EPR insert includes an EPR resonator that can nest inside the PET scanner. The EPR resonator includes a resonator that can receive the subject module, a shield encircling the resonator and one or more rapid scan coils (RS-coils) positioned around the shield. The shield can prevent electrical coupling between the RS-coils and the resonator while being transparent to annihilation photons and magnetic field scans.

Systems, devices and methods are provided for the monitoring and management of an individual's wellness and nutrition using analyte data from an in vivo analyte sensor. Generally, a sensor control device is provided for wear on the body. The sensor control device can include an in vivo analyte sensor for measuring an analyte level in a bodily fluid, an accelerometer for measuring the physical activity level of the subject, as well as communications circuitry for wirelessly transmitting data to a reader device. Furthermore, disclosed herein are embodiments of various graphical user interfaces for displaying analyte metrics on a reader device, comparing the analyte response of various foods and/or meals, modifying daily nutrient recommendations based on analyte metrics and physical activity level measurements, and other features described herein. Additionally, the embodiments disclosed herein can be used to monitor various types of analytes.

Methods, systems, and devices for menopause detection and treatment are described. A system may be configured to receive physiological data associated with a user from a wearable device, and identify one or more physiological indications of a hot flash experienced by the user based on the physiological data satisfying one or more thresholds. Additionally, the system may be configured to determine a metabolic efficiency metric associated with the user based on the received physiological data, and determine a menopause metric for the user based on the metabolic efficiency metric, where the menopause metric is associated with a relative probability that the user will experience menopausal symptoms. The system may then cause a graphical user interface (GUI) of a user device to display information associated with the identified hot flash and/or one or more messages associated with the menopause metric.