An apparatus for capturing a multispectral image of an object is described. The apparatus includes one or more means for transmitting a beam of laser light at a first wavelength and a beam of laser light at one or more additional wavelengths different from the first wavelength. There is a means for causing the beams of laser light to travel in a coaxial path and a moving mirror. The beams of light bounce off the mirror thereby producing a two dimensional projection pattern. This pattern travels from the mirror along a first path to an object and wherein some of the laser light penetrates the object and travels to an internal structure of the object. The reflection of the laser light returns to a photo detector along a path different from said first path.

A tissue disorder monitoring system includes at least two electrodes constructed and arranged to obtain analog electrical signals from a patient. An amplifier amplifies the analog electrical signals. Filter structure filters the amplified analog electrical signal. An A/D converter converts the amplified and filtered analog electrical signals to digitized electrical signals. A microprocessor circuit is constructed and arranged to execute an application that analyzes the digitized electrical signals to identify and to determine treatment data including a specific location and/or propagation of disordered tissue within the patient. A transmitter transmits data in a wireless manner. A power supply powers the device. A method locating disordered tissue in a patient is also disclosed.

Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

Image rotation in an endoscopic hyperspectral, fluorescence, and/or laser mapping imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.

A feedback-type intelligent syringe is provided, which includes a syringe needle and a needle seat, the syringe needle is provided with a first electrode and a second electrode for detecting impedance of a human tissue, the first electrode and the second electrode are electrically connected with a main control device, and the main control device is electrically connected with a displayer or a reminding device.

A method and system for non-invasive assessment and therapy planning for coronary artery disease from medical image data of a patient is disclosed. Geometric features representing at least a portion of a coronary artery tree of the patient are extracted from medical image data. Lesions are detected in coronary artery tree of the patient and a hemodynamic quantity of interest is computed at a plurality of points along the coronary artery tree including multiple points within the lesions based on the extracted geometric features using a machine learning model, resulting in an estimated pullback curve for the hemodynamic quantity of interest. Post-treatment values for the hemodynamic quantity of interest are predicted at the plurality of points along the coronary artery tree including the multiple points within the lesions for each of one or more candidate treatment options for the patient, resulting in a respective predicted post-treatment pullback curve for the hemodynamic quantity of interest for each of the one or more candidate treatment options. A visualization of a treatment prediction for at least one of the candidate treatment options is displayed.

Various implementations include a device for locating a position in a body. The device includes a first body portion. The first body portion has a first longitudinal axis. The device includes a second body portion. The second body portion is slidably coupled to the first body portion. The second body portion has a second longitudinal axis. The device includes a first set of markers disposed on the first body portion for measuring along the first longitudinal axis. The first set of markers includes at least two radiopaque markers. The device also includes a second set of markers disposed on the second body portion for measuring along the second longitudinal axis. The second set of markers includes at least two radiopaque markers. The first body portion is slidable along the second longitudinal axis. The second body portion is slidable along the first longitudinal axis.

Embodiments of the present disclosure pertain to transmission dielectric probes with at least one channel that extends across the probe. The channel includes a first opening on a first side of the transmission dielectric probe, and a second opening on a second side of the transmission dielectric probe. The first opening and the second opening are on opposite ends of the transmission dielectric probe, and the second opening is associated with an outer surface of the transmission dielectric probe. Additionally, the first opening and the second opening have different diameters, different geometries, or combinations thereof. Further embodiments pertain to methods of operating the transmission dielectric probes by placing the outer surface of the transmission dielectric probe on a surface of an object, transmitting a signal from a first channel through the surface and into the object, and receiving the transmitted signal back through a second channel.

A tissue detection system includes a probe having a body and an emission optical fiber extending from an input end through the probe body to an output end at a distal end portion of the probe body. The emission optical fiber defines a Numerical Aperture (NA). The tissue detection system further includes an emitter configured to output electromagnetic radiation and an optical coupler optically coupling the emitter with the input end of the emission optical fiber such that, in response to receiving the output from the emitter, electromagnetic radiation is input to the input end of the emission optical fiber. The optical coupler modifies the electromagnetic radiation such that the electromagnetic radiation input to the input end of the emission optical fiber defines an NA about equal to or less than the NA of the emission optical fiber.

Ultrasound device configured to carry out a HIFU treatment and to detect in real time during the HIFU treatment the temperature distribution in the area of treatment, comprising: an ultrasound probe comprising at least an array of piezoelectric or CMUT transducers, —piloting means of said ultrasound probe, computing means configured to receive and store said raw ultrasound signals reflected by said tissues and acquired by each of said piezoelectric or CMUT transducers, to process said reflected raw ultrasound signals in order to generate an ultrasound image, as well as to carry out other processing on said raw ultrasound signals reflected by said tissues, characterized in that computer programs are loaded on said computing means, configured to carry out the method for determining the actual acoustic heating rate of tissues, comprising the following steps: a) identifying, inside an ultrasound image (14), a region of interest (15) inside which an area to be treated (16) is provided, b) assigning a starting temperature distribution, by means of which a temperature value is assigned to each point of ROI, c) emitting a high intensity ultrasound beam (100) focused on a focal point (11) contained in said ROI for a predetermined time interval, and subsequently a broadband ultrasound pulse (200), and detecting the ultrasound signal reflected and/or emitted by the tissues under treatment, d) carrying out the frequency transform of said reflected ultrasound signal in response to said broadband ultrasound pulse (200), in order to obtain a reference frequency spectrum (200s), e) repeating steps c) and d) iteratively, thus obtaining a frequency spectrum for each iteration, f) assuming that the temperature at the focus (11) is equal to a predetermined temperature and function of the tissue in the treatment step when the frequency spectrum (202s) detected in response to a broadband ultrasound pulse (202) comprises a plurality of peaks (2021) not provided in the reference frequency spectrum (200s), g) determining the actual acoustic heating rate Q as a function of said predetermined temperature, of the intensity of said high intensity ultrasound beam (100).