A system and method of correlating or coregistering medical images is disclosed herein that includes acquiring a sur-face image of the patient's skin surface using a surface detector assembly comprising a surface frame and a camera system registered to the surface frame. Positional coordinates of one or more surface landmarks in the surface image are determined and a medical image of the patient is acquired having the surface frame depicted therein. A second surface image of the patient's skin surface is ac-quired that at least partially overlaps the previously acquired surface image. Positional coordinates of one or more surface landmarks in the second surface image are determined and compared with surface landmarks in the previous surface image. Common surface landmarks are determined based on the comparison and the medical images are coregistered based on positional coordinates of the common surface landmarks.

A method for identifying human joint characteristics, the method including the steps of: using a mobile imaging device, taking at least one image of the joint, and then identifying a joint pain location by identifying three different locations in the image near the joint, so that a center point between the locations can be triangulated.

A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

Driving an emitter to emit pulses of electromagnetic radiation according to a jitter specification in a hyperspectral, fluorescence, and laser mapping imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a driver for driving emissions by the emitter according to a jitter specification. The system is h that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.

Devices and methods for treating obesity are provided, including intragastric devices and methods of fabricating, deploying, inflating, locating, tracking, monitoring, deflating, and retrieving the same. In one embodiment, a device includes a balloon capsule having a distal end, a catheter having a proximal end and a distal end, a connector, a light sensor, and a balloon valve. At least one optical fiber extends along the length of the interior of the catheter and through the valve such that a distal end of the optical fiber is positioned at a distal end of the balloon capsule when the catheter is placed within the balloon capsule, and such that a proximal end of the optical fiber can be received by the light sensor.

Methods, systems, and computing platforms are disclosed. Exemplary implementations may: identify and store anatomical landmarks on a first reference digital image of a region of a human body; insert biopsy site identification data on the first reference digital image with the anatomical landmarks to form a second reference digital image; transform the second reference digital image into a mesh mask image; and overlay the mesh mask image on a third digital image of the region of the human body.

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Systems, methods, and devices for fluorescence imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array and a controller comprising a processor in electrical communication with the image sensor and the emitter. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

This document provides methods and devices for localizing, delineating and/or anchoring lesions for resection from a solid organ (e.g., liver, breast, or pancreas). For example, this document provides devices that can be positioned within liver tissue to help delineate liver tumor tissue from normal liver tissue and to help hold liver tumor tissue in position for resection.

What is provided is a method and apparatus for modifying bladder function comprising: applying a dermal patch having an integral electrode in proximity to a sacral or pudendal nerve; selecting the sacral or pudendal nerve by a sensor integral on the dermal patch; determining a stimulation corresponding to the sacral or pudendal nerve, by logic of the dermal patch; applying the stimulation by the electrodes and a stimulator integral to the dermal patch to produce an electric field; and selectively activating the sacral or pudendal nerve by the electric field.