A system comprising (1) a microelectrode array (MEA) component comprising an integrated multiplexed (MUX) logic circuit; and (2) a microprocessor, e.g., MOSFET, such as a CMOS, wherein the MEA is in electrical communication with the microprocessor such that signals produced by the microelectrodes are transmitted to the processor through the MUX. The use of a MUX reduces the number of outputs used to communicate signals from multiple microelectrodes to the microprocessor. The two components are removably engageable with each other such that after one or more uses, the engaged MEA can be removed and replaced with a new MEA, without the necessity of disposing the microprocessor.

A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.

The material stack of the present disclosure can be used for fabricating optical waveguides that are thin and flexible, and that can bend light around small turns. The stack of materials can include a polymer core and a cladding, which together can create a large difference in refractive index. As a result, light can remain within the core even when bent around radii where standard glass fibers could fail.

Methods and devices that use a subcutaneous implant to express lymph from the lymphatic system to promote drainage, drive normal lymph flow, and avoid acute decompensated heart failure, without the requirement of an intravascular procedure or device. Embodiments include a treatment device with a subcutaneous implant dimensioned to be implanted and positioned at a thoracic duct of a subject and a controller operable to cause the implant to compress the thoracic duct to express lymph, optionally using an implantable pressure sensor, and in which the subcutaneous implant comprises a balloon or cuff that at least partially surrounds a thoracic duct, wherein, in response to a reading from the sensor indicative of inadequate lymph flow, the controller causes the implant to perform a series of transient compressions of the thoracic duct to express lymph.

A method for assessing pain caused by administration of a drug solution includes: anesthetizing an experimental animal; inserting a measurement electrode into skeletal muscle of the anesthetized experimental animal; puncturing an injection needle into a predetermined part of the anesthetized experimental animal while measuring a myoelectric potential of the skeletal muscle with the measurement electrode; administering a drug solution to the anesthetized experimental animal; and (i) measuring a duration time of the myoelectric response caused by the administration of the drug solution, and/or (ii) measuring an EMG intensity obtained by integrating absolute values of myoelectric potentials during a period from occurrence of the myoelectric response by the administration of the drug solution to disappearance of the myoelectric response.

A universal implantable integrated circuit medical device platform having integral and monolithic circuit traces. The platform allows for implanting into a mammalian body single and multi-functional interface devices for sensing, monitoring stimulating and/or modulating physiological conditions within the body. Microelectronic circuitry may be integrated onto the platform or may be joined as modular components to the platform.

Systems and methods are provided for analyzing electrocardiogram (ECG) data of a patient using a substantial amount of ECG data. The systems receive ECG data from a sensing device positioned on a patient such as one or more ECG leads/electrodes that may be integrated in a smart device. The system may include an application that communicates with an ECG platform running on a server(s) that processes and analyzes the ECG data, e.g., using neural networks, to detect and/or predict various abnormalities, conditions and/or descriptors. The system may also determine a confidence score corresponding to the abnormalities, conditions and/or descriptors. The processed ECG data is used to generate a graphic user interface that is communicated from the server(s) to a computer for display in a user-friendly and interactive manner with enhanced accuracy.

A method, apparatus, and system for balancing a patient's knee joint during an orthopaedic surgical procedure includes measuring a conductance of a medial collateral ligament and a lateral collateral ligament of the patient's knee joint and balancing the tension of the medial and lateral collateral ligaments based on the measured conductance. The tension of the medial and lateral collateral ligaments may be balanced by reducing a difference between the measured conductance.

A bi-stable popper valve and a device for detecting blockage in a flow of a fluid are provided. The valve includes a membrane supporting two conformations: in a first conformation the membrane is convex in relation the upstream fluid, and in a second conformation the membrane can be concave in relation to the upstream fluid, such that in the first conformation the flow of the fluid through the membrane is prevented and in the second conformation the flow of the fluid through the membrane is permitted through a pore defined by the membrane in only the second conformation. The membrane changes from the first conformation to the second responsive to a pressure of the fluid meeting or exceeding an opening pressure value of the membrane. A sensor can detect a shift from the first conformation to the second conformation, indicating a flow, or absence of flow, of the fluid.