A heartbeat detection device includes a difference value calculation unit (3) for calculating, from a sampling data sequence of an electrocardiographic waveform of a living body, one of an amount of change and a degree of change of sampling data for each sampling time, a multiplication unit (4) for calculating, for each sampling time, a product by multiplying one of an amount of change and a degree of change of the sampling data at a time K by one of the sampling data at the time K and sampling data at a time before the time K by a predetermined time t, a peak detection unit (5) for detecting a peak of the product, and a heartbeat time determination unit (6) for setting time of the peak of the product as a heartbeat time.

A biosensor includes a PPG circuit that emits light directed at living tissue at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength and a second wavelength. Using absorption coefficients for substances at the plurality of wavelengths, concentration levels of a plurality of substances such as Nitric Oxide may then be determined from the spectral responses.

An imaging apparatus includes a light source that includes a diffusion plate and, in operation, emits, toward a subject, pulsed light that diverges; a photodetector that includes a photoelectric converter that, in operation, receives light from the subject and converts the light to an electric charge and an electric charge accumulator that, in operation, accumulates the electric charge, and, in operation, generates an electric signal based on the accumulated electric charge; and a control circuit that, in operation, controls the light source and the photodetector. The control circuit, in operation, causes the electric charge accumulator to start accumulating the electric charge when a period of time has passed after the control circuit has caused the light source to start emitting the pulsed light, and causes the electric charge accumulator to accumulate the electric charge corresponding to a component, among the light from the subject, that is scattered inside the subject.

Systems, methods, and graphical user interfaces are described herein for non-invasively detecting phrenic nerve stimulation during cardiac pacing therapy. Phrenic nerve stimulation information may be generated for one or more electrical pacing vectors at one or more power configurations. The phrenic nerve stimulation information may be displayed to a user for use in configuring and/or evaluating cardiac pacing therapy.

Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures indicative of brain states induced by the drug. The method also includes correlating the generated signatures with a database comprising information associated with a plurality of drug profiles, and determining, using the information, a molecular activity profile for the drug. The method further includes generating a report indicative of the effectiveness of the drug using the molecular activity profile.

Disclosed herein is a framework for facilitating patient signal analysis based on vector analysis. In accordance with one aspect, a set of vectors is generated from a patient signal data waveform. The vectors may be directed from a common center to points of interest on the patient signal data waveform. The framework may further extract one or more vector parameters from the set of vectors, and determine one or more vector ratios based on the vector parameters to monitor changes in the patient signal data waveform.

The invention relates to an apparatus for measuring the human body temperature. It comprises of an infrared temperature sensor for performing temperature sampling on a plurality M×N of sampling points, M≧3, N≧3. The temperatures of the sampling points with temperatures within the effective temperature range of the human body are averaged to obtain the body temperature of the human body. By collecting the temperatures of a plurality of sampling points of the measured object, the invention effectively avoids the errors that measurement of single point may produce (as may be caused by factors such as the environment); by screening for temperatures within the effective temperature range of the human body, the invention effectively avoids errors or interference produced by factors such as clothing or the environment. The improved accuracy and real-time measurement of body temperature bring convenience to people's lives.

An evoked potential measuring apparatus includes: an evoked potential acquiring section which is configured to acquire a plurality of evoked potential waveforms from a subject in response to stimulation; an average processing section which is configured to arithmetically average the plurality of evoked potential waveforms to acquire an average waveform; a first statistical value calculator which, each time a waveform set including an N (N is 2 or more) number of evoked potential waveforms is acquired, is configured to calculate a first statistical value of the waveform set; and an updation processing section which is configured to update the average waveform to eliminate a waveform set in which the first statistical value exceeds a first threshold, from the arithmetic average.

An extended wavelength defined as a length of a signal waveform corresponding to a locus traced by a detected signal of an inertial sensor in a time domain per unit time is calculated, and an activity state of an observed person observed by the inertial sensor is determined based on the extended wavelength.

Some embodiments of the present disclosure discuss an apparatus comprising a transceiver configured to generate and/or receive radio frequency (RF) electromagnetic signals, one or more antennae configured to radiate the generated RF electromagnetic signals toward a surface and to output signals corresponding to received reflections of the RF electromagnetic signals, and a processing circuitry configured to process the received reflections and/or the output signals so as to determine change in position of the apparatus with respect to the surface. The apparatus may be incorporated into a wearable garment and/or an adhesive patch, and it may be attached to an outer surface of a human or an animal body.