The present disclosure is directed to methods for improving a wakeful function in a subject suffering from an acquired cognitive deficiency by administering to the subject an effective amount of an upregulator of GABA.sub.B signaling, thereby improving the wakeful function in the subject. Another aspect of the disclosure us directed to methods for improving a wakeful function in a subject suffering from an acquired cognitive deficiency by administering to the subject an effective amount of an upregulator of GABA.sub.B signaling at night, in combination with administering an anterior-forebrain stimulating therapy when the subject is awake, thereby improving the wakeful function in the subject.

A method for obtaining a cycle of a physiological signal includes: a collection device for collecting a vibration signal of body movements; a processor for obtaining a physiological signal by processing the vibration signal; receiving a physiological signal value and a register value, comparing the physiological signal value with the register value, and reserving one of the physiological signal value and the register value; determining the physiological signal value having a corresponding time duration, reaching a given set time to be an extreme value, wherein the time duration is a time duration of the physiological signal value received is not exceeded; restarting the procedure and determining a next extreme value; obtaining the cycle of the physiological signal by processing the at least one extreme value; and displaying the cycle of the physiological signal in a display device.

In one embodiment, an apparatus (12) that samples a signal obtained or derived from an accelerometer, filters the samples, accumulates the filtered samples, and determines which limb the apparatus is associated with based on a comparison of the filtered accumulated samples and a threshold set.

An apparatus and a method for monitoring a bio-signal measuring condition are disclosed. The apparatus includes a bio-signal receiver configured to receive a bio-signal that is measured from a user, and a processor configured to extract any one or any combination of a waveform feature, a period feature, and an amplitude feature, from the received bio-signal, determine whether the extracted any one or any combination of the waveform feature, the period feature, and the amplitude feature are normal, using at least one predetermined determination reference corresponding to the extracted any one or any combination of the waveform feature, the period feature, and the amplitude features, and monitor a measuring condition of the received bio-signal, based on whether the extracted any one or any combination of the waveform feature, the period feature, and the amplitude feature are determined to be normal.

An apparatus and method for detecting a bio-signal feature are provided. The apparatus according to one aspect may include: a bio-signal acquirer configured to acquire a bio-signal; and a processor configured to generate an envelope signal of the bio-signal, and detect at least one feature of the bio-signal based on a difference between the envelope signal and the bio-signal.

A continuous and self-calibration method and system for monitoring oxygen saturation of a patient are provided. An example system includes a wearable device having a first optical sensor to measure a first red wavelength photoplethysmography (PPG) signal and a first infrared wavelength PPG signal and a second optical sensor to measure a second red wavelength PPG signal and a second infrared wavelength PPG signal. The system further includes a processor configured to repeatedly determine that conditions for recalibration of the first optical sensor are satisfied, determine a first ratio for obtaining the oxygen saturation, a first parameter for modifying the first red wavelength PPG signal, a second parameter for modifying the first infrared wavelength PPG signal, and a second ration for obtaining the oxygen saturation. The processor is further configured to determine a value of the oxygen saturation and provide a message regarding a health status of the patient.

A sleep state sensing method and a sleep state sensing system are provided. The sleep state sensing method includes: sensing a designated physiological state through an electronic device to generate a first physiological signal group and sensing the designated physiological state through a physiological signal sensing instrument to generate a second physiological signal group; calibrating the electronic device based on the first physiological signal group and the second physiological signal group such that the electronic device generates a third physiological signal group; and determining a sleep state through the third physiological signal group.

An electronic device includes a sensor configured to acquire a pulse wave of a subject and a controller configured to analyze, based on the pulse wave of the subject acquired by the sensor, the rate of change in the pulse wave at a predetermined time after the point in time exhibiting a peak of the pulse wave and to estimate the blood glucose level of the subject based on the rate of change.

Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration. The systems may generate a cardiogram for each source configuration from the modeled electromagnetic output of that source configuration for use in predicting the source location of an arrhythmia.

A magnetic field measurement system includes a magnetometer having at least one vapor cell, at least one light source to direct at least two light beams through the vapor cell(s), and at least one detector; at least one magnetic field generator to modify an external magnetic field experienced by the vapor cell(s); and at least one processor configured for: applying a first modulation pattern, b.sub.mod(t), to the magnetic field generator(s) to modulate a magnetic field at the vapor cell(s), where b.sub.mod(t)=[c.sub.x cos(ωt)+s.sub.x sin(ωt), c.sub.y cos(ωt)+s.sub.y sin(ωt), c.sub.z cos(ωt)+s.sub.z sin(ωt)], where c.sub.x, s.sub.x, c.sub.y, s.sub.y, c.sub.z, and s.sub.z are amplitudes and ω is a frequency; directing the light source(s) to direct the light beams through the vapor cell(s); receiving signals from the detector(s); and determining three orthogonal components of the external magnetic field using the received signals. Multi-frequency modulation patterns can alternatively be used.