This instant disclosure provides a heart rate detecting device which includes an image sensor. The image sensor generates a first mixed signal within a first interval and generates a second mixed signal within a second interval, wherein the first mixed signal contains light information of first multiple light wavelengths having a first intensity ratio from one another, and the second mixed signal contains light information of second multiple light wavelengths having a second intensity ratio, different from the first intensity ratio, from one another.

Monitoring apparatus for monitoring the pulse transit time and/or estimating one or more blood pressure parameters of a subject and the method of use of the monitoring apparatus. The apparatus comprises an upper arm unit for attaching to a subject's upper arm in use and comprising at least one motion sensor, a photoplethysmograph comprising at least one light source and at least one light detector and at least one display.

A system and method to input patient data including previous diagnosis, drugs, symptoms and treatment, open data and expert knowledge, and to use these inputs to create a patient clinical object (PCO), biomedical knowledge and rule based knowledge graphs, and to enrich the PCO using the biomedical knowledge graph. A meta diagnosis predictor is to use the PCO and the biomedical knowledge graph and/or the rule based knowledge graph in plural predictors of a diagnosis-based predictor to provide a set of diagnoses based on previous diagnoses, a drug-based predictor to provide a set of diagnoses based on drugs taken by the patient, a symptom-based predictor to provide a set of diagnoses based on symptoms of the patient and a treatment-based predictor to provide a set of diagnoses based on the treatments. Any of the sets of diagnoses may be combined to give a predicted primary diagnosis for the patient.

A method for providing a thermal feedback, includes executing a virtual reality application providing a virtual space that includes a virtual area to which an area temperature attribute is assigned, and a virtual object to which an object temperature attributed is assigned. An area event that reflects that a player character enters the virtual area is detected. A feedback device is controlled to output thermal feedback associated to the area temperature attribute when the area event is detected, the feedback device outputting the thermal feedback using a thermoelectric element performing a thermoelectric operation. An object event reflecting the player character is influenced by the virtual object is detected. The feedback device is controlled to override the thermal feedback associated to the area temperature attribute and output thermal feedback associated to the object temperature when the object is detected while the player character is in the virtual area.

A method and system for continually monitoring oxygenation levels in real-time in compartments of an animal limb, such as in a human leg or a human thigh or a forearm, can be used to assist in the diagnosis of a compartment syndrome. The method and system can include one or more near infrared compartment sensors in which each sensor can be provided with a compartment alignment mechanism and a central scan depth marker so that each sensor may be precisely positioned over a compartment of a living organism. The method and system can include a device for displaying oxygenation levels corresponding to respective compartment sensors that are measuring oxygenation levels of a compartment of interest. The method and system can also monitor the relationship between blood pressure and oxygenation levels and activate alarms based on predetermined conditions relating to the oxygenation levels or blood pressure or both.

An electronic device and a method for screening features for predicting a physiological state are provided. The method includes: obtaining multiple physiological data corresponding to multiple features; generating multiple first subsets of the multiple features according to the multiple physiological data based on a first model, wherein the multiple first subsets respectively correspond to the multiple physiological data; selecting a first feature from the multiple features according to the multiple first subsets, calculating a first relation index of the first feature and a second feature corresponding to the multiple features, and selecting the second feature as an accompanied feature of the first feature according to the first relation index; and outputting the first feature and the accompanied feature.

A method and apparatus for non-invasively determining a blood oxygen saturation level within tissue of an internal organ is provided. The method includes: applying a near infrared spectrophotometric sensor on an external surface of an organ; operating the sensor to emit light from a light source directly into the tissue of the organ at a first tissue location, and to sense the emitted light at a second tissue location, which emitted light has traveled through the tissue between the first and second tissue locations, and to produce signals representative of the intensity of the sensed emitted light; using a processor to execute instructions, which instructions cause the processor to: determine an attenuation value of the emitted light for each wavelength, and determine a blood oxygen saturation level of the organ tissue using the determined attenuation values for each of the plurality of wavelengths.

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.

Systems and methods are disclosed for providing recommended doses and instructions for pharmaceutical treatments by measuring physiological and/or electrophysiological signals from a subject and providing recommended doses and instructions of pharmaceuticals based at least in part on the measured signals. Further, the recommended doses and instructions are based at least in part on a subject's disease(s), disorder(s), or injuries and/or symptom(s) of such, and/or side effects of medications or treatments the subject is receiving. The recommended doses and instructions are personally tailored to the subject to precisely and personally address the subject's needs, and may be based in part on correlation with database(s) comprising historical data of the subject and/or other subjects to treat the subject's movement disorders, injuries to the body or brain, cognitive diseases and disorders, sleep diseases and disorders, chronic pain, or other conditions.

An intra-body communication system for monitoring physiological changes in a patient is provided. The system can include a first device implanted into a patient's body; a second device spaced apart from the first device; and a receiver for detecting and/or decoding the signals to monitor physiological changes in the patient. The first device and second device are capable of engaging in a two-way communication through transmission of one or more signals through at least a portion of the patient's body between the first device and the second device. In one embodiment, the signal may be an optical signal.